This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] See more...

Aliases for PAQR3 Gene

Aliases for PAQR3 Gene

  • Progestin And AdipoQ Receptor Family Member 3 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member III 2 3 4
  • Raf Kinase Trapping To Golgi 3 4
  • RKTG 3 4
  • PAQR3 5

External Ids for PAQR3 Gene

Previous GeneCards Identifiers for PAQR3 Gene

  • GC04M080266
  • GC04M080297
  • GC04M080165
  • GC04M080027
  • GC04M079808
  • GC04M075584

Summaries for PAQR3 Gene

Entrez Gene Summary for PAQR3 Gene

  • This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for PAQR3 Gene

PAQR3 (Progestin And AdipoQ Receptor Family Member 3) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot Summary for PAQR3 Gene

  • Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Additional gene information for PAQR3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAQR3 Gene

Genomics for PAQR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PAQR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAQR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAQR3

Top Transcription factor binding sites by QIAGEN in the PAQR3 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • E47
  • ER-alpha
  • HNF-3beta
  • HNF-4alpha1
  • HNF-4alpha2
  • RP58
  • Tal-1

Genomic Locations for PAQR3 Gene

Genomic Locations for PAQR3 Gene
chr4:78,887,127-78,939,438
(GRCh38/hg38)
Size:
52,312 bases
Orientation:
Minus strand
chr4:79,808,281-79,860,592
(GRCh37/hg19)
Size:
52,312 bases
Orientation:
Minus strand

Genomic View for PAQR3 Gene

Genes around PAQR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR3 Gene

Proteins for PAQR3 Gene

  • Protein details for PAQR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TCH7-PAQR3_HUMAN
    Recommended name:
    Progestin and adipoQ receptor family member 3
    Protein Accession:
    Q6TCH7
    Secondary Accessions:
    • A8K5B7
    • B3KP59
    • Q6PIQ1
    • Q86X05
    • Q8NCP9

    Protein attributes for PAQR3 Gene

    Size:
    311 amino acids
    Molecular mass:
    36217 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51571.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for PAQR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAQR3 Gene

Post-translational modifications for PAQR3 Gene

  • Ubiquitination at Lys7
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAQR3 Gene

Domains & Families for PAQR3 Gene

Gene Families for PAQR3 Gene

Protein Domains for PAQR3 Gene

InterPro:
Blocks:
  • Hly-III related proteins
ProtoNet:

Suggested Antigen Peptide Sequences for PAQR3 Gene

GenScript: Design optimal peptide antigens:
  • Raf kinase trapping to Golgi (PAQR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6TCH7

UniProtKB/Swiss-Prot:

PAQR3_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR3: view

Function for PAQR3 Gene

Molecular function for PAQR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Phenotypes From GWAS Catalog for PAQR3 Gene

Gene Ontology (GO) - Molecular Function for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17724343
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with PAQR3: view
genes like me logo Genes that share phenotypes with PAQR3: view

Animal Models for PAQR3 Gene

MGI Knock Outs for PAQR3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAQR3 Gene

Localization for PAQR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR3 Gene

Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 17724343
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PAQR3 Gene

Pathways & Interactions for PAQR3 Gene

PathCards logo

SuperPathways for PAQR3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with PAQR3: view

Pathways by source for PAQR3 Gene

Gene Ontology (GO) - Biological Process for PAQR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001933 negative regulation of protein phosphorylation IDA 17724343
GO:0010977 negative regulation of neuron projection development IDA 17724343
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA 17724343
GO:0034067 protein localization to Golgi apparatus IPI 17724343
genes like me logo Genes that share ontologies with PAQR3: view

No data available for SIGNOR curated interactions for PAQR3 Gene

Drugs & Compounds for PAQR3 Gene

No Compound Related Data Available

Transcripts for PAQR3 Gene

mRNA/cDNA for PAQR3 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR3

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for PAQR3 Gene

GeneLoc Exon Structure for
PAQR3

Expression for PAQR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAQR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR3 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PAQR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAQR3 Gene



Protein tissue co-expression partners for PAQR3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAQR3

SOURCE GeneReport for Unigene cluster for PAQR3 Gene:

Hs.657312

mRNA Expression by UniProt/SwissProt for PAQR3 Gene:

Q6TCH7-PAQR3_HUMAN
Tissue specificity: Widely expressed in a range of tissues.

Evidence on tissue expression from TISSUES for PAQR3 Gene

  • Kidney(4.4)
  • Nervous system(4.2)
  • Lung(3.9)
  • Liver(3.1)
  • Skin(2.8)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PAQR3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR3 Gene

Orthologs for PAQR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PAQR3 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PAQR3 30 31
  • 94.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PAQR3 30 31
  • 93.68 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PAQR3 31
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Paqr3 30 17 31
  • 90.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Paqr3 30
  • 87.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia PAQR3 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PAQR3 30 31
  • 80.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PAQR3 31
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia paqr3 30
  • 78.39 (n)
Str.15454 30
Zebrafish
(Danio rerio)
Actinopterygii paqr3b 31
  • 77 (a)
OneToMany
paqr3a 30 31
  • 71.12 (n)
OneToMany
zgc73098 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG7530 30 31
  • 48.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000144 30
  • 48.02 (n)
Worm
(Caenorhabditis elegans)
Secernentea paqr-3 30 31
  • 47.28 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 31
  • 23 (a)
ManyToMany
IZH2 31
  • 21 (a)
ManyToMany
Species where no ortholog for PAQR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PAQR3 Gene

ENSEMBL:
Gene Tree for PAQR3 (if available)
TreeFam:
Gene Tree for PAQR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAQR3: view image

Paralogs for PAQR3 Gene

Paralogs for PAQR3 Gene

(2) SIMAP similar genes for PAQR3 Gene using alignment to 3 proteins:

  • PAQR3_HUMAN
  • D6RDU4_HUMAN
  • F8W784_HUMAN
genes like me logo Genes that share paralogs with PAQR3: view

Variants for PAQR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAQR3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs138262352 Benign/Likely Benign: not specified; not provided 78,912,028(-) C/T NONSENSE,THREE_PRIME_UTR_VARIANT
rs386352343 Uncertain Significance: not provided 78,926,573(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for PAQR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PAQR3 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV deletion 23290073
nsv1006026 CNV loss 25217958
nsv829979 CNV gain 17160897

Variation tolerance for PAQR3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAQR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR3 Gene

Disorders for PAQR3 Gene

No disorders were found for PAQR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR3 Gene

Publications for PAQR3 Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 2 3 4
  2. Characterization of the topology and functional domains of RKTG. (PMID: 18547165) Luo X … Chen Y (The Biochemical journal 2008) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway. (PMID: 31095939) Chen L … Huang H (Experimental cell research 2019) 3

Products for PAQR3 Gene

  • Signalway Proteins for PAQR3

Sources for PAQR3 Gene