Aliases for PAPPA Gene
- Pappalysin 1 2 3 5
- IGFBP-4ase 2 3 4
- PAPP-A 2 3 4
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease 2 3
- Pregnancy-Associated Plasma Protein A, Pappalysin 1 2 3
- Differentially Placenta 1 Expressed Protein 2 3
- Aspecific BCL2 ARE-Binding Protein 2 2 3
- IGF-Dependent IGFBP-4 Protease 3 4
External Ids for PAPPA Gene
Previous GeneCards Identifiers for PAPPA Gene
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
GeneCards Summary for PAPPA Gene
PAPPA (Pappalysin 1) is a Protein Coding gene. Diseases associated with PAPPA include Orofaciodigital Syndrome Viii and Placenta Disease. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is PAPPA2.
UniProtKB/Swiss-Prot Summary for PAPPA Gene
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.