Aliases for PAPOLG Gene
External Ids for PAPOLG Gene
Previous GeneCards Identifiers for PAPOLG Gene
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAPOLG Gene
PAPOLG (Poly(A) Polymerase Gamma) is a Protein Coding gene. Diseases associated with PAPOLG include Chromosome 2P16.1-P15 Deletion Syndrome and Acute Cystitis. Among its related pathways are mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and polynucleotide adenylyltransferase activity. An important paralog of this gene is PAPOLA.
UniProtKB/Swiss-Prot Summary for PAPOLG Gene
Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.