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Aliases for PAOX Gene

Aliases for PAOX Gene

  • Polyamine Oxidase 2 3 4 5
  • Polyamine Oxidase (Exo-N4-Amino) 2 3
  • PAO 3 4
  • Peroxisomal N(1)-Acetyl-Spermine/Spermidine Oxidase 3
  • Peroxisomal N1-Acetyl-Spermine/Spermidine Oxidase 3
  • EC 1.5.3.13 4

External Ids for PAOX Gene

Previous GeneCards Identifiers for PAOX Gene

  • GC10P134665
  • GC10P134666
  • GC10P135081
  • GC10P135042
  • GC10P135192
  • GC10P128736

Summaries for PAOX Gene

GeneCards Summary for PAOX Gene

PAOX (Polyamine Oxidase) is a Protein Coding gene. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and polyamine oxidase activity. An important paralog of this gene is SMOX.

UniProtKB/Swiss-Prot for PAOX Gene

  • Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

Tocris Summary for PAOX Gene

Gene Wiki entry for PAOX Gene

Additional gene information for PAOX Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAOX Gene

Genomics for PAOX Gene

GeneHancer (GH) Regulatory Elements for PAOX Gene

Promoters and enhancers for PAOX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133377 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.9 -0.4 -358 2.3 ARID4B SIN3A DMAP1 ZNF2 ETS1 YY1 GLIS2 ZNF207 ZNF143 SP3 PAOX ECHS1 SCART1 MTG1 PIR35409
GH10J133381 Enhancer 0.4 Ensembl ENCODE 661.4 +2.0 1967 0.4 PAOX ENSG00000254536
GH10J132392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -970.8 -970832 32.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B PWWP2B TUBGCP2 ENSG00000235245 C10orf91 ZNF511 STK32C LOC105378568 PAOX PPP2R2D MTG1
GH10J133387 Enhancer 1.5 FANTOM5 Ensembl ENCODE 17.6 +11.2 11210 5 HDGF PKNOX1 ARNT YBX1 IRF4 YY1 ZNF143 SP3 NFYC JUNB ENSG00000254536 TUBGCP2 ENSG00000235245 SCART1 PAOX MTG1 ECHS1 CFAP46
GH10J133334 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 15 -43.5 -43473 2.9 ATF1 SIN3A GLI4 GLIS2 KLF7 KLF13 SP3 ZNF518A RFX3 GMEB1 CALY SCART1 ZNF511 PAOX ECHS1 TUBGCP2 VENTX MTG1 FUOM GC10M133326
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAOX gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • Max
  • c-Myc
  • Max1
  • SREBP-1c

Genomic Locations for PAOX Gene

Genomic Locations for PAOX Gene
chr10:133,379,234-133,391,696
(GRCh38/hg38)
Size:
12,463 bases
Orientation:
Plus strand
chr10:135,192,695-135,205,198
(GRCh37/hg19)
Size:
12,504 bases
Orientation:
Plus strand

Genomic View for PAOX Gene

Genes around PAOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAOX Gene

Proteins for PAOX Gene

  • Protein details for PAOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QHF9-PAOX_HUMAN
    Recommended name:
    Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
    Protein Accession:
    Q6QHF9
    Secondary Accessions:
    • D3DXI6
    • Q5VWY0
    • Q6QHF5
    • Q6QHF6
    • Q6QHF7
    • Q6QHF8
    • Q6QHG0
    • Q6QHG1
    • Q6QHG2
    • Q6QHG3
    • Q6QHG4
    • Q6QHG5
    • Q6QHG6
    • Q86WP9
    • Q8N555
    • Q8NCX3

    Protein attributes for PAOX Gene

    Size:
    649 amino acids
    Molecular mass:
    70290 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity).

    Alternative splice isoforms for PAOX Gene

neXtProt entry for PAOX Gene

Post-translational modifications for PAOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PAOX Gene

Domains & Families for PAOX Gene

Gene Families for PAOX Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PAOX Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6QHF9

UniProtKB/Swiss-Prot:

PAOX_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with PAOX: view

Function for PAOX Gene

Molecular function for PAOX Gene

UniProtKB/Swiss-Prot Function:
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
UniProtKB/Swiss-Prot CatalyticActivity:
N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2).
UniProtKB/Swiss-Prot Induction:
By polyamine analogs.

Enzyme Numbers (IUBMB) for PAOX Gene

Phenotypes From GWAS Catalog for PAOX Gene

Gene Ontology (GO) - Molecular Function for PAOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 20178365
GO:0016491 oxidoreductase activity IEA --
GO:0046592 polyamine oxidase activity IDA 16354669
GO:0052899 N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity IEA --
GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity IEA --
genes like me logo Genes that share ontologies with PAOX: view
genes like me logo Genes that share phenotypes with PAOX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAOX

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAOX Gene

Localization for PAOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAOX Gene

Peroxisome. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAOX gene
Compartment Confidence
peroxisome 5
extracellular 2
mitochondrion 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PAOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005777 peroxisome IEA --
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with PAOX: view

Pathways & Interactions for PAOX Gene

genes like me logo Genes that share pathways with PAOX: view

Pathways by source for PAOX Gene

UniProtKB/Swiss-Prot Q6QHF9-PAOX_HUMAN

  • Pathway: Amine and polyamine metabolism; spermine metabolism.

Gene Ontology (GO) - Biological Process for PAOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006596 polyamine biosynthetic process TAS --
GO:0006598 polyamine catabolic process IEA --
GO:0008215 spermine metabolic process IEA --
GO:0009446 putrescine biosynthetic process IDA 16354669
GO:0009447 putrescine catabolic process IDA 16354669
genes like me logo Genes that share ontologies with PAOX: view

No data available for SIGNOR curated interactions for PAOX Gene

Drugs & Compounds for PAOX Gene

(10) Drugs for PAOX Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
Febuxostat Approved Pharma Xanthine oxidase inhibitor 61

(9) Additional Compounds for PAOX Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-Acetylspermidine
  • 1-N-Acetylspermidine
  • An N-acetylspermidine
  • N(1)-Acetylspermidine
  • N-(3-((4-Aminobutyl)amino)propyl)-acetamide
  • N-(3-((4-Aminobutyl)amino)propyl)acetamide
14278-49-0
N1-acetylspermine
  • N'-acetylspermine
  • N'-monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-acetamide
  • N-Acetylspermine
25593-72-0
3-Acetamidobutanal
Acetamidopropanal
  • N-(3-Oxopropyl)acetamide
  • 3-Acetamidopropanal
  • 3AAP
Fe2+
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
15438-31-0

(5) Tocris Compounds for PAOX Gene

Compound Action Cas Number
1-Methyl-D-tryptophan Indoleamine 2,3-dioxygenase (IDO) inhibitor 110117-83-4
680C91 Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor 163239-22-3
Febuxostat Xanthine oxidase inhibitor 144060-53-7
LM 10 Selective tryptophan 2,3-dioxygenase (TDO) inhibitor 1316695-35-8
MDL 72527 Polyamine oxidase (PAO) inhibitor 93565-01-6
genes like me logo Genes that share compounds with PAOX: view

Transcripts for PAOX Gene

Unigene Clusters for PAOX Gene

Polyamine oxidase (exo-N4-amino):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAOX

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAOX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - -
SP11: -
SP12:

Relevant External Links for PAOX Gene

GeneLoc Exon Structure for
PAOX
ECgene alternative splicing isoforms for
PAOX

Expression for PAOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAOX Gene

This gene is overexpressed in Testis (x10.7).

Protein differential expression in normal tissues from HIPED for PAOX Gene

This gene is overexpressed in Heart (51.6) and Spleen (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAOX Gene



Protein tissue co-expression partners for PAOX Gene

NURSA nuclear receptor signaling pathways regulating expression of PAOX Gene:

PAOX

SOURCE GeneReport for Unigene cluster for PAOX Gene:

Hs.501578

mRNA Expression by UniProt/SwissProt for PAOX Gene:

Q6QHF9-PAOX_HUMAN
Tissue specificity: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.

Evidence on tissue expression from TISSUES for PAOX Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(3.1)
genes like me logo Genes that share expression patterns with PAOX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAOX Gene

Orthologs for PAOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAOX 34 33
  • 91.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PAOX 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PAOX 34 33
  • 83.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Paox 16 34 33
  • 80.69 (n)
rat
(Rattus norvegicus)
Mammalia Paox 33
  • 80.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAOX 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAOX 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAOX 34 33
  • 67.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAOX 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12053 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-275b16.2 33
  • 57.37 (n)
PAOX 34
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6721 33
fruit fly
(Drosophila melanogaster)
Insecta CG8032 34
  • 30 (a)
ManyToMany
CG7460 34
  • 29 (a)
ManyToMany
CG5653 34
  • 29 (a)
ManyToMany
CG10561 34
  • 28 (a)
ManyToMany
CG6034 34
  • 26 (a)
ManyToMany
CG7737 34
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea amx-3 34
  • 26 (a)
ManyToMany
hpo-15 34
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMS1 36
Species where no ortholog for PAOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAOX Gene

ENSEMBL:
Gene Tree for PAOX (if available)
TreeFam:
Gene Tree for PAOX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAOX: view image

Paralogs for PAOX Gene

Paralogs for PAOX Gene

(4) SIMAP similar genes for PAOX Gene using alignment to 3 proteins:

  • PAOX_HUMAN
  • B0QZA9_HUMAN
  • D3DXI4_HUMAN
genes like me logo Genes that share paralogs with PAOX: view

Variants for PAOX Gene

Sequence variations from dbSNP and Humsavar for PAOX Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000112512 -- 133,387,415(+) G/A intron_variant
rs1000427962 -- 133,385,444(+) C/T intron_variant
rs1000779390 -- 133,385,129(+) C/T intron_variant
rs1001002699 -- 133,385,862(+) C/A/G/T intron_variant
rs1001056362 -- 133,385,622(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAOX Gene

Variant ID Type Subtype PubMed ID
dgv123n27 CNV gain 19166990
dgv1486n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv2e196 CNV duplication 17116639
dgv35e55 CNV gain 17911159
dgv3e196 CNV duplication 17116639
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv3625030 CNV gain 21293372
nsv1037772 CNV gain 25217958
nsv1052904 CNV gain 25217958
nsv1070417 CNV deletion 25765185
nsv1118195 CNV deletion 24896259
nsv428243 CNV gain 18775914
nsv467509 CNV loss 19166990
nsv470980 CNV loss 18288195
nsv470981 CNV gain 18288195
nsv527785 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv552644 CNV loss 21841781
nsv7631 CNV deletion 18451855
nsv832040 CNV loss 17160897
nsv832041 CNV gain 17160897
nsv952707 CNV deletion 24416366

Variation tolerance for PAOX Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAOX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAOX Gene

Disorders for PAOX Gene

Additional Disease Information for PAOX

No disorders were found for PAOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAOX Gene

Publications for PAOX Gene

  1. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PMID: 12477380) Vujcic S … Porter CW (The Biochemical journal 2003) 3 4 22 58
  2. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. (PMID: 12660232) Wu T … McIntire WS (The Journal of biological chemistry 2003) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis. (PMID: 26547506) Salati S … AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators (International journal of cancer 2016) 3 58

Products for PAOX Gene

Sources for PAOX Gene

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