The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008] See more...

Aliases for PANX3 Gene

Aliases for PANX3 Gene

  • Pannexin 3 2 3 5
  • Pannexin-3 3 4
  • Gap Junction Protein Pannexin 3 3
  • PANX3 5
  • PX3 3
  • Px3 2

External Ids for PANX3 Gene

Previous GeneCards Identifiers for PANX3 Gene

  • GC11P126482
  • GC11P125994
  • GC11P124515
  • GC11P124019
  • GC11P123986
  • GC11P124481
  • GC11P120423

Summaries for PANX3 Gene

Entrez Gene Summary for PANX3 Gene

  • The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANX3 Gene

PANX3 (Pannexin 3) is a Protein Coding gene. Diseases associated with PANX3 include Oculodentodigital Dysplasia and Chronic Closed-Angle Glaucoma. Gene Ontology (GO) annotations related to this gene include gap junction hemi-channel activity and wide pore channel activity. An important paralog of this gene is PANX1.

UniProtKB/Swiss-Prot Summary for PANX3 Gene

Additional gene information for PANX3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PANX3 Gene

Genomics for PANX3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PANX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124611 Promoter 0.3 EPDnew 600.7 0.0 -41 0.1 PANX3 OR8Q1P lnc-OR8A1-1-002 OR8A1
GH11J124612 Enhancer 0.2 Ensembl 600.7 +0.8 789 0.4 PANX3 OR8B8 TBRG1
GH11J124607 Enhancer 0.8 Ensembl 0.7 -3.3 -3327 0.6 JUND PKNOX1 HDAC1 SOX6 FOXJ2 EP300 ZNF766 TAF9B NFE2 ZNF316 OR8B8 ROBO3 PANX3 OR8Q1P lnc-OR8A1-1-002 OR8A1
GH11J124605 Enhancer 0.5 Ensembl 0.4 -5.6 -5627 1.6 SPI1 GABPA ATF1 ZBTB33 ZKSCAN8 ROBO3 OR8B8 OR8Q1P lnc-OR8A1-1-002 PANX3 OR8A1
GH11J124595 Enhancer 0.4 Ensembl 0.4 -10.7 -10728 1.8 POLR2A HMBOX1 NR2F6 ATF2 OR8Q1P lnc-OR8A1-1-002 OR8B4 OR8B8 ROBO3 PANX3 lnc-OR8A1-1-001 OR8A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PANX3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PANX3

Top Transcription factor binding sites by QIAGEN in the PANX3 gene promoter:
  • ATF-2
  • ISGF-3
  • LCR-F1
  • p53
  • POU3F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-alpha
  • STAT1beta

Genomic Locations for PANX3 Gene

Genomic Locations for PANX3 Gene
chr11:124,611,428-124,620,356
(GRCh38/hg38)
Size:
8,929 bases
Orientation:
Plus strand
chr11:124,481,386-124,490,252
(GRCh37/hg19)
Size:
8,867 bases
Orientation:
Plus strand

Genomic View for PANX3 Gene

Genes around PANX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANX3 Gene

Proteins for PANX3 Gene

  • Protein details for PANX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QZ0-PANX3_HUMAN
    Recommended name:
    Pannexin-3
    Protein Accession:
    Q96QZ0

    Protein attributes for PANX3 Gene

    Size:
    392 amino acids
    Molecular mass:
    44683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PANX3 Gene

Post-translational modifications for PANX3 Gene

  • Glycosylation at Asn71
  • Modification sites at PhosphoSitePlus

Other Protein References for PANX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PANX3 Gene

Domains & Families for PANX3 Gene

Gene Families for PANX3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PANX3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PANX3 Gene

GenScript: Design optimal peptide antigens:
  • Pannexin-3 (PANX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96QZ0

UniProtKB/Swiss-Prot:

PANX3_HUMAN :
  • Belongs to the pannexin family.
Family:
  • Belongs to the pannexin family.
genes like me logo Genes that share domains with PANX3: view

Function for PANX3 Gene

Molecular function for PANX3 Gene

UniProtKB/Swiss-Prot Function:
Structural component of the gap junctions and the hemichannels.

Gene Ontology (GO) - Molecular Function for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity ISS --
GO:0015267 channel activity IEA --
GO:0022829 wide pore channel activity IBA 21873635
GO:0055077 NOT gap junction hemi-channel activity ISS --
genes like me logo Genes that share ontologies with PANX3: view
genes like me logo Genes that share phenotypes with PANX3: view

Animal Models for PANX3 Gene

MGI Knock Outs for PANX3:
  • Panx3 Panx3<tm1d(KOMP)Wtsi>
  • Panx3 Panx3<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PANX3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PANX3 Gene

Localization for PANX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANX3 Gene

Cell membrane. Multi-pass membrane protein. Cell junction, gap junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANX3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
nucleus 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005921 gap junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with PANX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PANX3 Gene

Pathways & Interactions for PANX3 Gene

PathCards logo

SuperPathways for PANX3 Gene

No Data Available

Interacting Proteins for PANX3 Gene

Gene Ontology (GO) - Biological Process for PANX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006812 cation transport IBA 21873635
GO:0007267 cell-cell signaling IEA,IBA 21873635
GO:0050716 positive regulation of interleukin-1 secretion IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with PANX3: view

No data available for Pathways by source and SIGNOR curated interactions for PANX3 Gene

Drugs & Compounds for PANX3 Gene

(2) Drugs for PANX3 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flufenamic acid Approved Pharma Channel blocker, Inhibitor, Pore Blocker, Antagonist Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 0
Carbenoxolone Experimental Pharma Inhibitor 0
genes like me logo Genes that share compounds with PANX3: view

Transcripts for PANX3 Gene

mRNA/cDNA for PANX3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PANX3

Alternative Splicing Database (ASD) splice patterns (SP) for PANX3 Gene

No ASD Table

Relevant External Links for PANX3 Gene

GeneLoc Exon Structure for
PANX3

Expression for PANX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PANX3 Gene

mRNA differential expression in normal tissues according to GTEx for PANX3 Gene

This gene is overexpressed in Testis (x7.0), Minor Salivary Gland (x6.8), Brain - Putamen (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hypothalamus (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PANX3

SOURCE GeneReport for Unigene cluster for PANX3 Gene:

Hs.99235

Evidence on tissue expression from TISSUES for PANX3 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with PANX3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANX3 Gene

Orthologs for PANX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PANX3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PANX3 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PANX3 30 31
  • 88.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Panx3 30
  • 87.67 (n)
Mouse
(Mus musculus)
Mammalia Panx3 30 17 31
  • 87.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PANX3 30 31
  • 87.07 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PANX3 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PANX3 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PANX3 30 31
  • 68.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PANX3 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101734171 30
  • 62.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii panx3 30 31
  • 58.81 (n)
OneToOne
Species where no ortholog for PANX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PANX3 Gene

ENSEMBL:
Gene Tree for PANX3 (if available)
TreeFam:
Gene Tree for PANX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PANX3: view image

Paralogs for PANX3 Gene

Paralogs for PANX3 Gene

(2) SIMAP similar genes for PANX3 Gene using alignment to 1 proteins:

  • PANX3_HUMAN
genes like me logo Genes that share paralogs with PANX3: view

Variants for PANX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PANX3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs34498516 - p.Gly95Arg
rs35569094 - p.Thr208Ala

Additional dbSNP identifiers (rs#s) for PANX3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PANX3 Gene

Variant ID Type Subtype PubMed ID
esv3627983 CNV loss 21293372
nsv1045156 CNV loss 25217958

Variation tolerance for PANX3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PANX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PANX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANX3 Gene

Disorders for PANX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PANX3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oculodentodigital dysplasia
  • oddd
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
charcot-marie-tooth disease
  • peroneal muscular atrophy
- elite association - COSMIC cancer census association via MalaCards
Search PANX3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PANX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PANX3 Gene

Publications for PANX3 Gene

  1. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. (PMID: 15028292) Baranova A … Panchin Y (Genomics 2004) 3 4 23
  2. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. (PMID: 20404334) Iwamoto T … Yamada Y (The Journal of biological chemistry 2010) 3 23
  3. Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3. (PMID: 29222846) Guerrero J … Amédée J (Journal of tissue engineering and regenerative medicine 2018) 3
  4. Human stem cells express pannexins. (PMID: 29357945) Hainz N … Meier C (BMC research notes 2018) 3
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3

Products for PANX3 Gene

Sources for PANX3 Gene