Aliases for PANX1 Gene
External Ids for PANX1 Gene
Previous GeneCards Identifiers for PANX1 Gene
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
GeneCards Summary for PANX1 Gene
PANX1 (Pannexin 1) is a Protein Coding gene. Diseases associated with PANX1 include Oocyte Maturation Defect 7 and Ischemia. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Transmission across Electrical Synapses. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and actin binding. An important paralog of this gene is PANX3.
UniProtKB/Swiss-Prot Summary for PANX1 Gene
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116).
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).