Aliases for PANO1 Gene

Aliases for PANO1 Gene

  • Proapoptotic Nucleolar Protein 1 2 3 4 5
  • PANO 2 3 4
  • Pre-MRNA-Splicing Factor Cwc22-Like 3
  • PANO1 5

External Ids for PANO1 Gene

Previous GeneCards Identifiers for PANO1 Gene

  • GC11P000797

Summaries for PANO1 Gene

GeneCards Summary for PANO1 Gene

PANO1 (Proapoptotic Nucleolar Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for PANO1 Gene

  • Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from degradation. May act as a tumor suppressor (PubMed:22094112).

Additional gene information for PANO1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PANO1 Gene

Genomics for PANO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PANO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000794 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -0.2 -174 5.1 HNRNPL CTCF PRDM10 RFX1 POLR2A BACH1 TARDBP LARP7 MTA2 ZNF143 MN297023 MN297024 PANO1 SLC25A22 lnc-PIDD1-1 RPLP2 MOB2 TMEM80 CD151 EPS8L2
GH11J000788 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -6.3 -6341 2.2 KDM1A ZNF143 ZIC2 ZSCAN4 POLR2A PATZ1 ZNF341 NRF1 KLF9 SP2 CEND1 lnc-SLC25A22-1 LOC171391 PIDD1 CRACR2B MN297023 PANO1 SLC25A22
GH11J000793 Enhancer 0.4 ENCODE dbSUPER 0.7 -2.9 -2897 0.2 POLR2A CEND1 MN297023 PANO1 SLC25A22 lnc-PIDD1-1 lnc-SLC25A22-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PANO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PANO1

Genomic Locations for PANO1 Gene

Genomic Locations for PANO1 Gene
chr11:796,633-799,185
(GRCh38/hg38)
Size:
2,553 bases
Orientation:
Plus strand

Genomic View for PANO1 Gene

Genes around PANO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANO1 Gene

Proteins for PANO1 Gene

  • Protein details for PANO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    I0J062-PANO1_HUMAN
    Recommended name:
    Proapoptotic nucleolar protein 1
    Protein Accession:
    I0J062

    Protein attributes for PANO1 Gene

    Size:
    215 amino acids
    Molecular mass:
    22842 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PANO1 Gene

Post-translational modifications for PANO1 Gene

No Post-translational modifications

Other Protein References for PANO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PANO1 Gene

Domains & Families for PANO1 Gene

Gene Families for PANO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PANO1 Gene

ProtoNet:
genes like me logo Genes that share domains with PANO1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PANO1 Gene

Function for PANO1 Gene

Molecular function for PANO1 Gene

UniProtKB/Swiss-Prot Function:
Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from degradation. May act as a tumor suppressor (PubMed:22094112).
UniProtKB/Swiss-Prot Induction:
Up-regulated after serum withdrawal.

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PANO1 Gene

Localization for PANO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANO1 Gene

Nucleus, nucleolus. Note=Colocalizes with CDKN2A/p14ARF in the nucleolus. {ECO:0000269 PubMed:22094112}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANO1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PANO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA 22094112
genes like me logo Genes that share ontologies with PANO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PANO1 Gene

Pathways & Interactions for PANO1 Gene

PathCards logo

SuperPathways for PANO1 Gene

No Data Available

Interacting Proteins for PANO1 Gene

Gene Ontology (GO) - Biological Process for PANO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0031647 regulation of protein stability IDA 22094112
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 22094112
GO:0043065 positive regulation of apoptotic process IDA 22094112
genes like me logo Genes that share ontologies with PANO1: view

No data available for Pathways by source and SIGNOR curated interactions for PANO1 Gene

Drugs & Compounds for PANO1 Gene

No Compound Related Data Available

Transcripts for PANO1 Gene

mRNA/cDNA for PANO1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PANO1 Gene

No ASD Table

Relevant External Links for PANO1 Gene

GeneLoc Exon Structure for
PANO1

Expression for PANO1 Gene

mRNA Expression by UniProt/SwissProt for PANO1 Gene:

I0J062-PANO1_HUMAN
Tissue specificity: Widely expressed.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANO1 Gene

Orthologs for PANO1 Gene

Evolution for PANO1 Gene

ENSEMBL:
Gene Tree for PANO1 (if available)
TreeFam:
Gene Tree for PANO1 (if available)

No data available for Orthologs for PANO1 Gene

Paralogs for PANO1 Gene

No data available for Paralogs for PANO1 Gene

Variants for PANO1 Gene

Additional dbSNP identifiers (rs#s) for PANO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PANO1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Additional Variant Information for PANO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PANO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for PANO1 Gene

Disorders for PANO1 Gene

No disorders were found for PANO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANO1 Gene

Publications for PANO1 Gene

  1. A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF. (PMID: 22094112) Watari A … Yutsudo M (Experimental cell research 2012) 2 3 4
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for PANO1 Gene

Sources for PANO1 Gene