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Aliases for PANK4 Gene

Aliases for PANK4 Gene

  • Pantothenate Kinase 4 2 3 5
  • Pantothenic Acid Kinase 4 3 4
  • EC 4 56
  • HPanK4 3 4

External Ids for PANK4 Gene

Previous GeneCards Identifiers for PANK4 Gene

  • GC01M002452
  • GC01M002100
  • GC01M002309
  • GC01M002472
  • GC01M002429
  • GC01M001719

Summaries for PANK4 Gene

Entrez Gene Summary for PANK4 Gene

  • This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for PANK4 Gene

PANK4 (Pantothenate Kinase 4) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include pantothenate kinase activity. An important paralog of this gene is PANK1.

UniProtKB/Swiss-Prot for PANK4 Gene

  • Plays a role in the physiological regulation of the intracellular CoA concentration.

Gene Wiki entry for PANK4 Gene

Additional gene information for PANK4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANK4 Gene

Genomics for PANK4 Gene

GeneHancer (GH) Regulatory Elements for PANK4 Gene

Promoters and enhancers for PANK4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I002522 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.7 +0.1 123 7.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 ZNF766 ZNF207 PANK4 ENSG00000224387 MORN1 FAAP20 LOC100129534 ENSG00000234396 SLC35E2 MIB2 SLC35E2B LOC100129381
GH01I002495 Enhancer 0.7 ENCODE 12.6 +30.3 30294 1 HDGF SAP130 EBF1 DMAP1 GLIS2 HSF1 ZNF600 IKZF2 GATAD2A ZNF687 ENSG00000229393 ENSG00000224387 PANK4 MMEL1 MORN1 GC01P002503 PLCH2
GH01I002499 Enhancer 0.6 ENCODE 12.6 +26.6 26567 1.1 NR2F1 MNT BCL11B HIC1 BCL11A PATZ1 GLIS1 ZFP36 ENSG00000224387 PANK4 MORN1 GC01P002503 ENSG00000229393 PLCH2
GH01I002543 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -20.5 -20458 7.5 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ENSG00000272449 GC01M002542 LOC100288379 CDK11A SLC35E2 LOC100129381 TNFRSF14 FAAP20 MMEL1 RER1
GH01I003181 Enhancer 0.6 ENCODE dbSUPER 4.8 -656.7 -656665 2.8 MYNN NFATC1 MNT GC01P003185 PANK4 LOC105378606 PRDM16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PANK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PANK4 gene promoter:

Genomic Locations for PANK4 Gene

Genomic Locations for PANK4 Gene
18,098 bases
Minus strand

Genomic View for PANK4 Gene

Genes around PANK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANK4 Gene

Proteins for PANK4 Gene

  • Protein details for PANK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pantothenate kinase 4
    Protein Accession:
    Secondary Accessions:
    • B9DI84
    • Q53EU3
    • Q5TA84
    • Q7RTX3
    • Q9H3X5

    Protein attributes for PANK4 Gene

    773 amino acids
    Molecular mass:
    85991 Da
    Quaternary structure:
    • Homodimer. Interacts with PKM (By similarity).

neXtProt entry for PANK4 Gene

Selected DME Specific Peptides for PANK4 Gene


Post-translational modifications for PANK4 Gene

  • Ubiquitination at Lys137, isoforms=234, and Lys487

Domains & Families for PANK4 Gene

Gene Families for PANK4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PANK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type II pantothenate kinase family.
  • Belongs to the type II pantothenate kinase family.
genes like me logo Genes that share domains with PANK4: view

Function for PANK4 Gene

Molecular function for PANK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (R)-pantothenate = ADP + (R)-4-phosphopantothenate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by feedback inhibition by CoA and its thioesters.
UniProtKB/Swiss-Prot Function:
Plays a role in the physiological regulation of the intracellular CoA concentration.

Enzyme Numbers (IUBMB) for PANK4 Gene

Phenotypes From GWAS Catalog for PANK4 Gene

Gene Ontology (GO) - Molecular Function for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004594 pantothenate kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PANK4: view
genes like me logo Genes that share phenotypes with PANK4: view

Clone Products

  • Addgene plasmids for PANK4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PANK4 Gene

Localization for PANK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANK4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANK4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PANK4: view

Pathways & Interactions for PANK4 Gene

genes like me logo Genes that share pathways with PANK4: view

UniProtKB/Swiss-Prot Q9NVE7-PANK4_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Gene Ontology (GO) - Biological Process for PANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PANK4: view

No data available for SIGNOR curated interactions for PANK4 Gene

Drugs & Compounds for PANK4 Gene

(2) Drugs for PANK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pantothenic acid Approved, Vet_approved Nutra 26
ATP Investigational Nutra Agonist 0

(6) Additional Compounds for PANK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (R)-4'-phospho-N-pantothenoyl-L-cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-b-alanyl]-L-Cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanyl]-L-Cysteine
  • 4'-P-N-Pantothenoylcysteine
  • 4'-Phospho-N-pantothenoylcysteine
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • (R)-4'-phosphopantothenate
  • 4'-P-Pantothenate
  • 4'-Phosphopantothenate
  • D-4'-Phosphopantothenate
  • D-4'-Phosphopantothenic acid
  • N-((R)-Pantothenoyl)-L-cysteine
  • N-Pantothenoylcystein
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
genes like me logo Genes that share compounds with PANK4: view

Transcripts for PANK4 Gene

Unigene Clusters for PANK4 Gene

Pantothenate kinase 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for PANK4

Alternative Splicing Database (ASD) splice patterns (SP) for PANK4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP8: - - -
SP10: - -
SP11: -

ExUns: 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21
SP1: - - -
SP2: - - -
SP7: -

Relevant External Links for PANK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PANK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PANK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PANK4 Gene

This gene is overexpressed in Lymph node (7.9) and Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PANK4 Gene

Protein tissue co-expression partners for PANK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PANK4 Gene:


SOURCE GeneReport for Unigene cluster for PANK4 Gene:


mRNA Expression by UniProt/SwissProt for PANK4 Gene:

Tissue specificity: Ubiquitously expressed with higher expression in the muscle.

Evidence on tissue expression from TISSUES for PANK4 Gene

  • Nervous system(4.7)
  • Kidney(4.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with PANK4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PANK4 Gene

Orthologs for PANK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PANK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PANK4 33 34
  • 99.35 (n)
(Monodelphis domestica)
Mammalia PANK4 34
  • 93 (a)
(Bos Taurus)
Mammalia PANK4 33 34
  • 87.54 (n)
(Canis familiaris)
Mammalia PANK4 33 34
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Pank4 33
  • 86.03 (n)
(Mus musculus)
Mammalia Pank4 33 16 34
  • 85.36 (n)
(Ornithorhynchus anatinus)
Mammalia PANK4 34
  • 85 (a)
(Gallus gallus)
Aves PANK4 33 34
  • 76.37 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pank4 33
  • 72 (n)
Str.20093 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2107 33
(Danio rerio)
Actinopterygii pank4 33 34
  • 74.5 (n)
zgc66285 33
fruit fly
(Drosophila melanogaster)
Insecta CG5828 33 34
  • 51.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010073 33
  • 49.12 (n)
(Caenorhabditis elegans)
Secernentea pnk-4 33
  • 46.52 (n)
pnk-1 34
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR729C 33
  • 57.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00869g 33
  • 52.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB1 33 34 36
  • 50.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PANK2 33
  • 50.7 (n)
(Oryza sativa)
Liliopsida Os09g0533100 33
  • 50.86 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03154 33
  • 58.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4B4.01c 33
  • 50.15 (n)
Species where no ortholog for PANK4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PANK4 Gene

Gene Tree for PANK4 (if available)
Gene Tree for PANK4 (if available)

Paralogs for PANK4 Gene

Paralogs for PANK4 Gene

(2) SIMAP similar genes for PANK4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PANK4: view

Variants for PANK4 Gene

Sequence variations from dbSNP and Humsavar for PANK4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs966358882 A colorectal cancer sample 2,514,418(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000059023 -- 2,517,627(-) A/G 3_prime_UTR_variant, intron_variant
rs1000135094 -- 2,517,927(-) G/A intron_variant
rs1000462164 -- 2,526,013(-) G/T 5_prime_UTR_variant, intron_variant
rs1000515170 -- 2,517,825(-) A/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PANK4 Gene

Variant ID Type Subtype PubMed ID
nsv998482 CNV loss 25217958
nsv951557 CNV deletion 24416366
nsv824031 CNV gain 20364138
nsv823920 CNV gain 20364138
nsv818222 CNV loss 17921354
nsv7171 OTHER inversion 18451855
nsv545081 CNV loss 21841781
nsv545080 CNV loss 21841781
nsv545079 CNV loss 21841781
nsv545077 CNV gain 21841781
nsv545076 CNV gain 21841781
nsv470685 CNV gain 18288195
nsv470684 CNV loss 18288195
nsv1145307 CNV deletion 24896259
nsv1126965 CNV deletion 24896259
nsv1122281 CNV deletion 24896259
nsv1119397 CNV insertion 24896259
nsv1116581 CNV tandem duplication 24896259
nsv1 OTHER inversion 15895083
esv3402792 CNV duplication 20981092
esv2583485 CNV insertion 19546169
esv1165961 CNV insertion 17803354
dgv50n54 CNV loss 21841781
dgv1n27 CNV loss 19166990
dgv15n106 CNV tandem duplication 24896259

Variation tolerance for PANK4 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.77; 91.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PANK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANK4 Gene

Disorders for PANK4 Gene

Additional Disease Information for PANK4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PANK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANK4 Gene

Publications for PANK4 Gene

  1. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. (PMID: 11479594) Zhou B … Hayflick SJ (Nature genetics 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2). (PMID: 16132722) Li Y … Fang F (Molecular and cellular biochemistry 2005) 3 22 58
  4. [Screening susceptibility genes of type 2 diabetes in Chinese population by single nucleotide polymorphism analysis]. (PMID: 16038259) Li Y … Fang FD (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2005) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PANK4 Gene

Sources for PANK4 Gene

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