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Aliases for PANK1 Gene

Aliases for PANK1 Gene

  • Pantothenate Kinase 1 2 3 3 5
  • Pantothenic Acid Kinase 1 3 4
  • PANK 3 4
  • Pantothenate Kinase 2
  • EC 4
  • HPanK1 4
  • HPanK 4

External Ids for PANK1 Gene

Previous HGNC Symbols for PANK1 Gene

  • PANK

Previous GeneCards Identifiers for PANK1 Gene

  • GC10M090564
  • GC10M091473
  • GC10M091007
  • GC10M091005
  • GC10M091332
  • GC10M084976

Summaries for PANK1 Gene

Entrez Gene Summary for PANK1 Gene

  • This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

GeneCards Summary for PANK1 Gene

PANK1 (Pantothenate Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include pantothenate kinase activity. An important paralog of this gene is PANK2.

UniProtKB/Swiss-Prot for PANK1 Gene

  • Plays a role in the physiological regulation of the intracellular CoA concentration.

Gene Wiki entry for PANK1 Gene

Additional gene information for PANK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PANK1 Gene

Genomics for PANK1 Gene

GeneHancer (GH) Regulatory Elements for PANK1 Gene

Promoters and enhancers for PANK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J089641 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 656.8 +0.9 850 5.7 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PANK1 ENSG00000249962 LOC105378421 KIF20B ENSG00000235100 LINC00865 ENSG00000240996 ENSG00000225836 GC10M089602
GH10J089700 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.5 -56.5 -56493 3.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B KIF20B LINC00865 ENSG00000235100 PANK1 GC10P089733
GH10J089667 Enhancer 0.5 ENCODE 15.2 -23.1 -23122 1.7 SKI HLF HMG20A TEAD3 LINC00865 PANK1 ENSG00000235100 GC10M089668 ENSG00000225836
GH10J089655 Enhancer 0.7 ENCODE 8.2 -10.1 -10133 1.2 SOX13 RXRA TEAD1 MAX REST PPARG RAD21 YY1 SP1 HNF1A LINC00865 PANK1 ENSG00000225836 GC10M089668
GH10J089699 Enhancer 0.9 ENCODE 5.5 -54.0 -54047 0.2 MLX ARID4B DMAP1 YY1 NFKBIZ RXRA SP5 REST PPARG KAT8 KIF20B ENSG00000240996 ENSG00000235100 FLJ37201 LINC00865 PANK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PANK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PANK1 gene promoter:
  • FOXO4
  • AhR
  • Evi-1
  • NF-1
  • Egr-4
  • NF-1/L

Genomic Locations for PANK1 Gene

Genomic Locations for PANK1 Gene
66,076 bases
Minus strand
66,076 bases
Minus strand

Genomic View for PANK1 Gene

Genes around PANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PANK1 Gene

Proteins for PANK1 Gene

  • Protein details for PANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pantothenate kinase 1
    Protein Accession:
    Secondary Accessions:
    • A6NIP0
    • Q7RTX6
    • Q7Z495
    • Q8TBQ8

    Protein attributes for PANK1 Gene

    598 amino acids
    Molecular mass:
    64339 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH26296.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PANK1 Gene

    Alternative splice isoforms for PANK1 Gene


neXtProt entry for PANK1 Gene

Post-translational modifications for PANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PANK1 Gene

Domains & Families for PANK1 Gene

Gene Families for PANK1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PANK1 Gene

Suggested Antigen Peptide Sequences for PANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal extension, present in isoform 1 may be the regulatory domain.
  • Belongs to the type II pantothenate kinase family.
  • The N-terminal extension, present in isoform 1 may be the regulatory domain.
  • Belongs to the type II pantothenate kinase family.
genes like me logo Genes that share domains with PANK1: view

Function for PANK1 Gene

Molecular function for PANK1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the physiological regulation of the intracellular CoA concentration.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (R)-pantothenate = ADP + (R)-4-phosphopantothenate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by feedback inhibition by CoA and its thioesters. Strongly inhibited by acetyl-CoA and by manyl-CoA and also inhibited by high concentration of non-esterified CoA (CoASH) (By similarity).
UniProtKB/Swiss-Prot Induction:
Isoform 1 is induced by bezafibrate, a hypolipidemic drug which acts as an agonist of peroxisome proliferator activator receptor alpha (PPARA), while isoform 2 levels decrease slightly.

Enzyme Numbers (IUBMB) for PANK1 Gene

Phenotypes From GWAS Catalog for PANK1 Gene

Gene Ontology (GO) - Molecular Function for PANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004594 pantothenate kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PANK1: view
genes like me logo Genes that share phenotypes with PANK1: view

Animal Models for PANK1 Gene

MGI Knock Outs for PANK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PANK1

miRNA for PANK1 Gene

miRTarBase miRNAs that target PANK1

Clone Products

  • Addgene plasmids for PANK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PANK1 Gene

Localization for PANK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PANK1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PANK1 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
endosome 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IEA --
GO:0030118 clathrin coat IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with PANK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PANK1 Gene

Pathways & Interactions for PANK1 Gene

genes like me logo Genes that share pathways with PANK1: view

Pathways by source for PANK1 Gene

UniProtKB/Swiss-Prot Q8TE04-PANK1_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Gene Ontology (GO) - Biological Process for PANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009108 coenzyme biosynthetic process TAS --
GO:0015937 coenzyme A biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PANK1: view

No data available for SIGNOR curated interactions for PANK1 Gene

Drugs & Compounds for PANK1 Gene

(2) Drugs for PANK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pantothenic acid Approved, Vet_approved Nutra 26
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(7) Additional Compounds for PANK1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (R)-4'-Phosphopantothenoyl-L-cysteine
  • N-((R)-4'-Phosphopantothenoyl)-L-cysteine
  • N-[(R)-4'-Phosphopantothenoyl]-L-cysteine
  • (R)-4'-phospho-N-Pantothenoyl-L-cysteine
  • (R)-N-[N-[2-Hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-b-alanyl]-L-cysteine
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • (R)-4'-Phosphopantothenate
  • 4'-P-Pantothenate
  • 4'-Phosphopantothenate
  • D-4'-Phosphopantothenic acid
  • Phosphopantothenic acid
  • N-((R)-Pantothenoyl)-L-cysteine
  • N-Pantothenoylcystein
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
genes like me logo Genes that share compounds with PANK1: view

Transcripts for PANK1 Gene

Unigene Clusters for PANK1 Gene

Pantothenate kinase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for PANK1

Alternative Splicing Database (ASD) splice patterns (SP) for PANK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP2: - -
SP3: -
SP4: -

Relevant External Links for PANK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PANK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PANK1 Gene

This gene is overexpressed in Liver (x8.9).

Protein differential expression in normal tissues from HIPED for PANK1 Gene

This gene is overexpressed in Pancreatic juice (50.4) and Liver (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PANK1 Gene

Protein tissue co-expression partners for PANK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PANK1 Gene:


SOURCE GeneReport for Unigene cluster for PANK1 Gene:


mRNA Expression by UniProt/SwissProt for PANK1 Gene:

Tissue specificity: Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.

Evidence on tissue expression from TISSUES for PANK1 Gene

  • Nervous system(4.5)
  • Muscle(4.3)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with PANK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PANK1 Gene

Orthologs for PANK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PANK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PANK1 34 33
  • 99.16 (n)
(Ornithorhynchus anatinus)
Mammalia PANK1 34
  • 92 (a)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
-- 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Pank1 33
  • 90.77 (n)
(Bos Taurus)
Mammalia PANK1 34 33
  • 90.75 (n)
(Monodelphis domestica)
Mammalia PANK1 34
  • 86 (a)
(Mus musculus)
Mammalia Pank1 16 34 33
  • 85.9 (n)
(Gallus gallus)
Aves PANK1 34
  • 94 (a)
(Anolis carolinensis)
Reptilia PANK1 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pank1 33
  • 80.44 (n)
(Danio rerio)
Actinopterygii pank1a 34
  • 79 (a)
pank1b 34 33
  • 76.33 (n)
Dr.11467 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011715 33
  • 62.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta fbl 34 33
  • 61.93 (n)
(Caenorhabditis elegans)
Secernentea pnk-4 34
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB1 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Cin.14853 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14853 33
Species where no ortholog for PANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PANK1 Gene

Gene Tree for PANK1 (if available)
Gene Tree for PANK1 (if available)
Evolutionary constrained regions (ECRs) for PANK1: view image

Paralogs for PANK1 Gene

Paralogs for PANK1 Gene

(2) SIMAP similar genes for PANK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PANK1: view

Variants for PANK1 Gene

Sequence variations from dbSNP and Humsavar for PANK1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000108144 -- 89,583,711(-) G/A 3_prime_UTR_variant
rs1000169241 -- 89,593,349(-) C/G intron_variant
rs1000225933 -- 89,645,149(-) T/C coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000228905 -- 89,624,083(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000288814 -- 89,601,865(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PANK1 Gene

Variant ID Type Subtype PubMed ID
esv3624165 CNV loss 21293372
nsv527532 CNV loss 19592680

Variation tolerance for PANK1 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PANK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PANK1 Gene

Disorders for PANK1 Gene

Additional Disease Information for PANK1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PANK1 Gene

Publications for PANK1 Gene

  1. Cloning and characterization of a novel human pantothenate kinase gene. (PMID: 11809413) Ni X … Mao Y (The international journal of biochemistry & cell biology 2002) 2 3 4 22 58
  2. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. (PMID: 17631502) Hong BS … Park HW (The Journal of biological chemistry 2007) 3 4 22 58
  3. PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression. (PMID: 14523052) Ramaswamy G … Jackowski S (Journal of lipid research 2004) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C … Peltonen L (Nature genetics 2009) 3 44 58

Products for PANK1 Gene

Sources for PANK1 Gene

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