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Aliases for PALM3 Gene

Aliases for PALM3 Gene

  • Paralemmin 3 2 3 5
  • Paralemmin-3 3 4

External Ids for PALM3 Gene

Previous GeneCards Identifiers for PALM3 Gene

  • GC19M014026
  • GC19M014164
  • GC19M013737

Summaries for PALM3 Gene

GeneCards Summary for PALM3 Gene

PALM3 (Paralemmin 3) is a Protein Coding gene. Diseases associated with PALM3 include Nerve Compression Syndrome. An important paralog of this gene is PALM2-AKAP2.

UniProtKB/Swiss-Prot for PALM3 Gene

  • ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.

Additional gene information for PALM3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALM3 Gene

Genomics for PALM3 Gene

GeneHancer (GH) Regulatory Elements for PALM3 Gene

Promoters and enhancers for PALM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014059 Enhancer 1.2 ENCODE dbSUPER 660.8 +1.2 1208 3.7 CTCF ELF3 MNT CBFA2T2 ZNF121 CSDE1 ZBTB7A SP1 PPARG SP5 PALM3 PRKACA IL27RA
GH19J014063 Enhancer 0.4 Ensembl 621.1 -1.1 -1090 0.4 CEBPG CEBPB HLF PALM3 EEF1DP1
GH19J014071 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.8 -11.5 -11490 4.4 ZNF652 ZFX CTCF ELF3 ZNF148 NKRF ZNF687 CDC5L TFE3 ZBTB7A MIR1199 MISP3 PALM3 DDX39A DCAF15 PRKACA CCDC130 RFX1 TRMT1 GC19M014079
GH19J014080 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 16.1 -19.4 -19362 2.6 SP1 ZFX SIX5 ZNF148 NKRF POLR2A CEBPG GTF2F1 ZNF384 ZNF687 GC19M014079 PALM3 PRKACA ZSWIM4 CCDC130 RFX1 PKN1 DCAF15 DNAJB1 C19orf67
GH19J013879 Promoter/Enhancer 1.6 Ensembl ENCODE 12.8 +180.6 180632 3.5 SP1 CC2D1A CTCF ELF3 ZNF148 GTF2F1 ZNF687 AHR MAFK TFE3 CC2D1A C19orf57 PALM3 EEF1DP1 MISP3 GC19P013876 NANOS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PALM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PALM3 gene promoter:
  • AML1a
  • CUTL1
  • HOXA5
  • Lhx3a
  • MZF-1
  • NF-kappaB1
  • Spz1
  • SRF
  • SRF (504 AA)

Genomic Locations for PALM3 Gene

Genomic Locations for PALM3 Gene
chr19:14,053,365-14,062,111
(GRCh38/hg38)
Size:
8,747 bases
Orientation:
Minus strand
chr19:14,164,177-14,169,971
(GRCh37/hg19)
Size:
5,795 bases
Orientation:
Minus strand

Genomic View for PALM3 Gene

Genes around PALM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALM3 Gene

Proteins for PALM3 Gene

  • Protein details for PALM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDB9-PALM3_HUMAN
    Recommended name:
    Paralemmin-3
    Protein Accession:
    A6NDB9

    Protein attributes for PALM3 Gene

    Size:
    673 amino acids
    Molecular mass:
    71695 Da
    Quaternary structure:
    • Interacts with SIGIRR.

neXtProt entry for PALM3 Gene

Post-translational modifications for PALM3 Gene

  • Palmitoylated on Cys-667 and Cys-669 and prenylated on Cys-670; which is required for membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALM3 Gene

No data available for DME Specific Peptides for PALM3 Gene

Domains & Families for PALM3 Gene

Gene Families for PALM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PALM3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PALM3 Gene

GenScript: Design optimal peptide antigens:
  • Paralemmin-3 (PALM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NDB9

UniProtKB/Swiss-Prot:

PALM3_HUMAN :
  • Belongs to the paralemmin family.
Family:
  • Belongs to the paralemmin family.
genes like me logo Genes that share domains with PALM3: view

Function for PALM3 Gene

Molecular function for PALM3 Gene

UniProtKB/Swiss-Prot Function:
ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for PALM3 Gene

Gene Ontology (GO) - Molecular Function for PALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21187075
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PALM3: view

Phenotypes for PALM3 Gene

genes like me logo Genes that share phenotypes with PALM3: view

Animal Models for PALM3 Gene

MGI Knock Outs for PALM3:
  • Palm3 Palm3<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PALM3 - Now 50% OFF >
  • * PALM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PALM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PALM3 Gene

Localization for PALM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALM3 Gene

Cytoplasm. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PALM3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PALM3: view

Pathways & Interactions for PALM3 Gene

PathCards logo

SuperPathways for PALM3 Gene

No Data Available

Interacting Proteins for PALM3 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344996%0d9606.ENSP00000228434%0d9606.ENSP00000466933%0d9606.ENSP00000435355%0d
Selected Interacting proteins: ENSP00000344996 A6NDB9-PALM3_HUMAN for PALM3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA,IBA 21187075
GO:0008063 Toll signaling pathway IBA,IMP 21187075
GO:0032496 response to lipopolysaccharide IBA,IDA 21187075
genes like me logo Genes that share ontologies with PALM3: view

No data available for Pathways by source and SIGNOR curated interactions for PALM3 Gene

Drugs & Compounds for PALM3 Gene

No Compound Related Data Available

Transcripts for PALM3 Gene

mRNA/cDNA for PALM3 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PALM3 Gene

Paralemmin 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PALM3 - Now 50% OFF >
  • * PALM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PALM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PALM3 Gene

No ASD Table

Relevant External Links for PALM3 Gene

GeneLoc Exon Structure for
PALM3
ECgene alternative splicing isoforms for
PALM3

Expression for PALM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PALM3 Gene

mRNA differential expression in normal tissues according to GTEx for PALM3 Gene

This gene is overexpressed in Liver (x11.9), Kidney - Cortex (x8.1), Stomach (x6.4), and Pancreas (x4.9).

Protein differential expression in normal tissues from HIPED for PALM3 Gene

This gene is overexpressed in Pancreas (18.1), Fetal Brain (15.6), and Liver (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PALM3 Gene



Protein tissue co-expression partners for PALM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PALM3 Gene:

PALM3

SOURCE GeneReport for Unigene cluster for PALM3 Gene:

Hs.444298

Evidence on tissue expression from TISSUES for PALM3 Gene

  • Liver(4.4)
  • Kidney(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with PALM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PALM3 Gene

Orthologs for PALM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PALM3 35 34
  • 99.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PALM3 35 34
  • 78.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PALM3 35 34
  • 76.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Palm3 17 35 34
  • 70.08 (n)
rat
(Rattus norvegicus)
Mammalia Palm3 34
  • 69.91 (n)
oppossum
(Monodelphis domestica)
Mammalia PALM3 35
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii palm3 35
  • 27 (a)
OneToOne
Species where no ortholog for PALM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALM3 Gene

ENSEMBL:
Gene Tree for PALM3 (if available)
TreeFam:
Gene Tree for PALM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PALM3: view image

Paralogs for PALM3 Gene

Paralogs for PALM3 Gene

genes like me logo Genes that share paralogs with PALM3: view

Variants for PALM3 Gene

Sequence variations from dbSNP and Humsavar for PALM3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000103341 -- 14,063,364(-) C/T upstream_transcript_variant
rs1000361288 -- 14,057,952(-) A/G intron_variant
rs1000385823 -- 14,056,631(-) G/A intron_variant
rs1000949044 -- 14,053,090(-) A/G downstream_transcript_variant
rs1001112963 -- 14,063,979(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PALM3 Gene

Variant ID Type Subtype PubMed ID
nsv578642 CNV gain 21841781
nsv833761 CNV loss 17160897

Variation tolerance for PALM3 Gene

Gene Damage Index Score: 7.27; 81.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PALM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PALM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALM3 Gene

Disorders for PALM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PALM3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nerve compression syndrome
  • compression neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search PALM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PALM3

genes like me logo Genes that share disorders with PALM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PALM3 Gene

Publications for PALM3 Gene

  1. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. (PMID: 21187075) Chen X … Qian G (Biochemical and biophysical research communications 2011) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58

Products for PALM3 Gene

Sources for PALM3 Gene

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