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Aliases for PALM2 Gene

Aliases for PALM2 Gene

  • Paralemmin 2 2 3 5
  • A Kinase (PRKA) Anchor Protein 2 3
  • Paralemmin-2 3
  • AKAP2 3

External Ids for PALM2 Gene

Previous GeneCards Identifiers for PALM2 Gene

  • GC09U990194
  • GC09P104136
  • GC09P106000
  • GC09P107922
  • GC09P111443
  • GC09P112403
  • GC09P082002

Summaries for PALM2 Gene

GeneCards Summary for PALM2 Gene

PALM2 (Paralemmin 2) is a Protein Coding gene. Diseases associated with PALM2 include Dysplastic Nevus Syndrome. An important paralog of this gene is PALM2-AKAP2.

Additional gene information for PALM2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALM2 Gene

Genomics for PALM2 Gene

GeneHancer (GH) Regulatory Elements for PALM2 Gene

Promoters and enhancers for PALM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I109640 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 68 1.5 CTCF MXI1 SUZ12 SIN3A BMI1 RFX5 ZNF335 E2F1 CTBP1 GLIS2 PALM2 ENSG00000232939
GH09I109745 Enhancer 0.9 Ensembl ENCODE 23.1 +105.0 104972 1.2 PKNOX1 INSM2 MAX FEZF1 ZIC2 ZNF2 YY1 ZNF335 POLR2A ZNF600 PALM2 ENSG00000232939 PALM2-AKAP2 AKAP2
GH09I110026 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.9 +389.0 388995 6.3 FOXA2 ZFP64 ETS1 YY1 ZNF213 ATF7 FOS ZNF202 RXRA REST PALM2-AKAP2 PALM2 RPL21P87 AKAP2
GH09I109751 Enhancer 0.7 Ensembl ENCODE 19.6 +110.7 110715 0.6 PRDM6 FOXA2 FOXA3 MZF1 FEZF1 PALM2 ENSG00000232939 PALM2-AKAP2 AKAP2
GH09I109965 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +327.7 327693 5.7 HDGF BMI1 BATF IRF4 RAD21 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 AKAP2 PALM2-AKAP2 PALM2 GC09M110025
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PALM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PALM2 gene promoter:

Genomic Locations for PALM2 Gene

Genomic Locations for PALM2 Gene
chr9:109,640,788-109,951,476
(GRCh38/hg38)
Size:
310,689 bases
Orientation:
Plus strand
chr9:112,403,068-112,713,756
(GRCh37/hg19)

Genomic View for PALM2 Gene

Genes around PALM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALM2 Gene

Proteins for PALM2 Gene

  • Protein details for PALM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXS6-PALM2_HUMAN
    Recommended name:
    Paralemmin-2
    Protein Accession:
    Q8IXS6
    Secondary Accessions:
    • A9Z1X9
    • Q8N9D5
    • Q96DU1

    Protein attributes for PALM2 Gene

    Size:
    379 amino acids
    Molecular mass:
    42185 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39306.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PALM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PALM2 Gene

Post-translational modifications for PALM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALM2 Gene

No data available for DME Specific Peptides for PALM2 Gene

Domains & Families for PALM2 Gene

Gene Families for PALM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PALM2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PALM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXS6

UniProtKB/Swiss-Prot:

PALM2_HUMAN :
  • Belongs to the paralemmin family.
Family:
  • Belongs to the paralemmin family.
genes like me logo Genes that share domains with PALM2: view

Function for PALM2 Gene

Phenotypes From GWAS Catalog for PALM2 Gene

Phenotypes for PALM2 Gene

genes like me logo Genes that share phenotypes with PALM2: view

miRNA for PALM2 Gene

miRTarBase miRNAs that target PALM2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PALM2 Gene

Localization for PALM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALM2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PALM2 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PALM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PALM2: view

Pathways & Interactions for PALM2 Gene

SuperPathways for PALM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PALM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008360 regulation of cell shape IEA --
genes like me logo Genes that share ontologies with PALM2: view

No data available for Pathways by source and SIGNOR curated interactions for PALM2 Gene

Drugs & Compounds for PALM2 Gene

No Compound Related Data Available

Transcripts for PALM2 Gene

mRNA/cDNA for PALM2 Gene

(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PALM2 Gene

No ASD Table

Relevant External Links for PALM2 Gene

GeneLoc Exon Structure for
PALM2
ECgene alternative splicing isoforms for
PALM2

Expression for PALM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PALM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PALM2 Gene

This gene is overexpressed in Fetal Brain (56.9) and Frontal cortex (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PALM2 Gene



Protein tissue co-expression partners for PALM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PALM2 Gene:

PALM2

mRNA Expression by UniProt/SwissProt for PALM2 Gene:

Q8IXS6-PALM2_HUMAN
Tissue specificity: Expressed in infantile heart and muscle, and fibroblasts.

Evidence on tissue expression from TISSUES for PALM2 Gene

  • Liver(4.2)
  • Muscle(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PALM2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PALM2 Gene

Orthologs for PALM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PALM2 33 34
  • 99.65 (n)
-- 34
  • 1 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PALM2 33 34
  • 93.92 (n)
-- 34
ManyToMany
dog
(Canis familiaris)
Mammalia AKAP2 33
  • 93.92 (n)
PALM2 34
OneToMany
mouse
(Mus musculus)
Mammalia Palm2 33 16
  • 89.72 (n)
Gm20459 34
  • 10 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia AKAP2 34
  • 26 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP2 34
OneToMany
chicken
(Gallus gallus)
Aves AKAP2 34
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 12 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia palm2 33
  • 72.48 (n)
zebrafish
(Danio rerio)
Actinopterygii palm2 33 34
  • 63.97 (n)
Species where no ortholog for PALM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALM2 Gene

ENSEMBL:
Gene Tree for PALM2 (if available)
TreeFam:
Gene Tree for PALM2 (if available)

Paralogs for PALM2 Gene

Paralogs for PALM2 Gene

(2) SIMAP similar genes for PALM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PALM2: view

Variants for PALM2 Gene

Sequence variations from dbSNP and Humsavar for PALM2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000016585 -- 109,756,504(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000023453 -- 109,757,273(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000027258 -- 109,717,592(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000043650 -- 109,762,812(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000059769 -- 109,680,612(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PALM2 Gene

Variant ID Type Subtype PubMed ID
dgv1500e214 CNV loss 21293372
dgv2177e212 CNV loss 25503493
dgv4124n106 CNV deletion 24896259
esv1279948 CNV insertion 17803354
esv1764066 CNV deletion 17803354
esv1922439 CNV deletion 18987734
esv25332 CNV loss 19812545
esv2563678 CNV deletion 19546169
esv2610332 CNV deletion 19546169
esv2670341 CNV deletion 23128226
esv2673594 CNV deletion 23128226
esv2738914 CNV deletion 23290073
esv3304422 CNV mobile element insertion 20981092
esv3389822 CNV insertion 20981092
esv3391064 CNV duplication 20981092
esv3426937 CNV insertion 20981092
esv3545291 CNV deletion 23714750
esv3621440 CNV loss 21293372
esv3621444 CNV gain 21293372
esv3621447 CNV loss 21293372
esv4643 CNV loss 18987735
esv9371 CNV loss 19470904
esv994161 CNV deletion 20482838
esv995500 CNV insertion 20482838
nsv1038477 CNV loss 25217958
nsv1045508 CNV loss 25217958
nsv1076198 CNV deletion 25765185
nsv1077173 CNV deletion 25765185
nsv1113012 CNV deletion 24896259
nsv1117523 CNV tandem duplication 24896259
nsv1125065 CNV duplication 24896259
nsv1137497 CNV deletion 24896259
nsv1148105 CNV deletion 26484159
nsv428222 CNV loss 18775914
nsv466479 CNV loss 19166990
nsv499708 OTHER inversion 21111241
nsv507527 OTHER sequence alteration 20534489
nsv509317 CNV insertion 20534489
nsv527195 CNV loss 19592680
nsv615149 CNV loss 21841781
nsv6661 CNV insertion 18451855
nsv7430 OTHER inversion 18451855
nsv831686 CNV gain 17160897
nsv831687 CNV gain 17160897
nsv831688 CNV gain+loss 17160897
nsv957747 CNV deletion 24416366

Variation tolerance for PALM2 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PALM2 Gene

Human Gene Mutation Database (HGMD)
PALM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PALM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALM2 Gene

Disorders for PALM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PALM2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
dysplastic nevus syndrome
  • familial atypical multiple mole-melanoma
- elite association - COSMIC cancer census association via MalaCards
Search PALM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PALM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PALM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PALM2 Gene

Publications for PALM2 Gene

  1. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. (PMID: 11478809) Hu B … Kilimann MW (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  2. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (PMID: 22456796) Imamura M … Kadowaki T (Human molecular genetics 2012) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 44 58
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58

Products for PALM2 Gene

Sources for PALM2 Gene

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