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This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
PALLD (Palladin, Cytoskeletal Associated Protein) is a Protein Coding gene. Diseases associated with PALLD include Pancreatic Cancer 1 and Pancreatic Cancer. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is MYPN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 11598191 |
GO:0051371 | muscle alpha-actinin binding | TAS | 16125169 |
GO:0098632 | cell-cell adhesion mediator activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | 11598191 |
GO:0001726 | ruffle | IEA | -- |
GO:0002102 | podosome | IEA | -- |
GO:0005634 | nucleus | IDA | 11598191 |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytoskeletal Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003334 | keratinocyte development | IEA | -- |
GO:0003382 | epithelial cell morphogenesis | IEA | -- |
GO:0007010 | cytoskeleton organization | NAS | 11598191 |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IBA | 21873635 |
GO:0007411 | axon guidance | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
ExUns: | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | ||||||||||||
SP3: | |||||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PALLD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC477351 30 |
|
||
PALLD 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Palld 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100360205 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PALLD 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PALLD 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | PALLD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | palld 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1924 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | palld 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14105 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.17 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
640053 | Uncertain Significance: Pancreatic adenocarcinoma | 168,878,325(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
641520 | Uncertain Significance: Pancreatic adenocarcinoma | 168,924,286(+) | T/G | MISSENSE_VARIANT | |
648376 | Uncertain Significance: Pancreatic adenocarcinoma | 168,921,627(+) | G/A | MISSENSE_VARIANT | |
650493 | Uncertain Significance: Pancreatic adenocarcinoma | 168,913,931(+) | G/A | MISSENSE_VARIANT | |
652423 | Uncertain Significance: Pancreatic adenocarcinoma | 168,878,349(+) | C/G | MISSENSE_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
pancreatic cancer 1 |
|
|
pancreatic cancer |
|
|
myocardial infarction |
|
|
myopathy, spheroid body |
|
|
dysplastic nevus syndrome |
|
|