Aliases for PALD1 Gene

Aliases for PALD1 Gene

  • Phosphatase Domain Containing Paladin 1 2 3 5
  • KIAA1274 2 3 4
  • Paladin 2 3 4
  • PALD 3 4
  • Phosphatase Domain Containing, Paladin 1 2
  • Palladin 3

External Ids for PALD1 Gene

Previous HGNC Symbols for PALD1 Gene

  • PALD
  • KIAA1274

Previous GeneCards Identifiers for PALD1 Gene

  • GC10P072239
  • GC10P070478

Summaries for PALD1 Gene

GeneCards Summary for PALD1 Gene

PALD1 (Phosphatase Domain Containing Paladin 1) is a Protein Coding gene. Diseases associated with PALD1 include Otomycosis. An important paralog of this gene is PTPDC1.

Additional gene information for PALD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PALD1 Gene

Genomics for PALD1 Gene

GeneHancer (GH) Regulatory Elements for PALD1 Gene

Promoters and enhancers for PALD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J070477 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 528.3 +20.7 20683 3.4 ZSCAN5C MYC USF1 ZNF639 EP300 ZIC2 ZBTB10 TCF7 ZNF423 GABPA PALD1 NODAL PCBD1 lnc-NODAL-1
GH10J070458 Enhancer 0.8 ENCODE 500.7 +0.3 335 1.7 FOS ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 ATF2 ZNF341 OSR2 KLF9 PALD1 NPFFR1 lnc-NODAL-1
GH10J070459 Enhancer 0.2 ENCODE 500.7 +1.5 1466 0.2 PALD1 EIF4EBP2 lnc-NODAL-1
GH10J070492 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 27.1 +35.7 35698 2.8 SP1 ZNF623 POLR2A FOS NBN SPI1 SMARCA5 ZFHX2 USF1 IRF4 PALD1 YY1P1 lnc-ADAMTS14-3
GH10J070403 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -53.4 -53366 3.6 FOXK2 HNRNPK ZBTB40 EP300 POLR2G SP1 NCOR1 GTF2E2 PHF8 TEAD4 EIF4EBP2 piR-34414 lnc-LRRC20-2 piR-56759-054 LRRC20 PALD1 NODAL ENSG00000280401
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PALD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PALD1

Genomic Locations for PALD1 Gene

Genomic Locations for PALD1 Gene
chr10:70,458,545-70,568,450
(GRCh38/hg38)
Size:
109,906 bases
Orientation:
Plus strand
chr10:72,238,564-72,328,206
(GRCh37/hg19)
Size:
89,643 bases
Orientation:
Plus strand

Genomic View for PALD1 Gene

Genes around PALD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PALD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PALD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALD1 Gene

Proteins for PALD1 Gene

  • Protein details for PALD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULE6-PALD_HUMAN
    Recommended name:
    Paladin
    Protein Accession:
    Q9ULE6
    Secondary Accessions:
    • B2RMS1
    • B9EGC6
    • Q5JTK7
    • Q5JTK8

    Protein attributes for PALD1 Gene

    Size:
    856 amino acids
    Molecular mass:
    96754 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86588.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for PALD1 Gene

Post-translational modifications for PALD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PALD1 Gene

No data available for DME Specific Peptides for PALD1 Gene

Domains & Families for PALD1 Gene

Gene Families for PALD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PALD1 Gene

Suggested Antigen Peptide Sequences for PALD1 Gene

GenScript: Design optimal peptide antigens:
  • Paladin (PALD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULE6

UniProtKB/Swiss-Prot:

PALD_HUMAN :
  • Belongs to the paladin family.
Family:
  • Belongs to the paladin family.
genes like me logo Genes that share domains with PALD1: view

Function for PALD1 Gene

Phenotypes From GWAS Catalog for PALD1 Gene

Gene Ontology (GO) - Molecular Function for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with PALD1: view

Phenotypes for PALD1 Gene

genes like me logo Genes that share phenotypes with PALD1: view

Animal Models for PALD1 Gene

MGI Knock Outs for PALD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PALD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PALD1 Gene

Localization for PALD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PALD1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA 22354871
genes like me logo Genes that share ontologies with PALD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PALD1 Gene

Pathways & Interactions for PALD1 Gene

PathCards logo

SuperPathways for PALD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PALD1: view

No data available for Pathways by source and SIGNOR curated interactions for PALD1 Gene

Drugs & Compounds for PALD1 Gene

(1) Drugs for PALD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PALD1: view

Transcripts for PALD1 Gene

mRNA/cDNA for PALD1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PALD1

Alternative Splicing Database (ASD) splice patterns (SP) for PALD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:

Relevant External Links for PALD1 Gene

GeneLoc Exon Structure for
PALD1

Expression for PALD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PALD1 Gene

Protein differential expression in normal tissues from HIPED for PALD1 Gene

This gene is overexpressed in Heart (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PALD1 Gene



Protein tissue co-expression partners for PALD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PALD1

SOURCE GeneReport for Unigene cluster for PALD1 Gene:

Hs.202351

mRNA Expression by UniProt/SwissProt for PALD1 Gene:

Q9ULE6-PALD_HUMAN
Tissue specificity: Expressed in endothelial cells, and in certain larger vessels, in mural cells. In the brain, possibly expressed in microglia. Expressed in peripheral blood mononuclear cells (at protein level).

Evidence on tissue expression from TISSUES for PALD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PALD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PALD1 Gene

Orthologs for PALD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PALD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PALD1 31 30
  • 97.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1274 31 30
  • 87.17 (n)
OneToMany
-- 31
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIAA1274 30
  • 86.49 (n)
PALD1 31
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pald1 30
  • 81.93 (n)
mouse
(Mus musculus)
Mammalia Pald1 17 31 30
  • 81.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PALD1 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PALD1 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PALD1 31 30
  • 72.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PALD1 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pald1 30
  • 63.44 (n)
zebrafish
(Danio rerio)
Actinopterygii pald1a 30
  • 62.51 (n)
pald1b 31
  • 50 (a)
OneToOne
pald 30
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62010 30
  • 41.68 (n)
rice
(Oryza sativa)
Liliopsida Os03g0586700 30
  • 41.56 (n)
Species where no ortholog for PALD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALD1 Gene

ENSEMBL:
Gene Tree for PALD1 (if available)
TreeFam:
Gene Tree for PALD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PALD1: view image

Paralogs for PALD1 Gene

Paralogs for PALD1 Gene

genes like me logo Genes that share paralogs with PALD1: view

Variants for PALD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PALD1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
718337 Likely Benign: not provided 70,533,946(+) C/T MISSENSE_VARIANT
768371 Benign: not provided 70,529,223(+) C/A INTRON_VARIANT
789204 Benign: not provided 70,538,924(+) C/T SYNONYMOUS_VARIANT
rs10999406 - p.Gly828Arg
rs2275060 - p.Ser141Leu

Additional dbSNP identifiers (rs#s) for PALD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PALD1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
esv3386498 CNV duplication 20981092
nsv1043245 CNV loss 25217958
nsv1150136 CNV insertion 26484159
nsv24389 CNV deletion 16902084
nsv467367 CNV loss 19166990
nsv517624 CNV loss 19592680
nsv551480 CNV loss 21841781
nsv7065 CNV insertion 18451855
nsv950976 CNV deletion 24416366

Variation tolerance for PALD1 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PALD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PALD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALD1 Gene

Disorders for PALD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PALD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
otomycosis
  • singapore ear
- elite association - COSMIC cancer census association via MalaCards
Search PALD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PALD1

genes like me logo Genes that share disorders with PALD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PALD1 Gene

Publications for PALD1 Gene

  1. Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema. (PMID: 29133847) Egaña I … German Mouse Clinic Consortium (Scientific reports 2017) 2 3 54
  2. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. (PMID: 22354871) Wallgard E … Hellström M (Developmental dynamics : an official publication of the American Association of Anatomists 2012) 3 4 54
  3. Negative regulators of insulin signaling revealed in a genome-wide functional screen. (PMID: 19727444) Huang SM … Gekakis N (PloS one 2009) 3 23 54
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  5. USP45 and Spindly are part of the same complex implicated in cell migration. (PMID: 30258100) Conte C … Perez-Oliva AB (Scientific reports 2018) 3 54

Products for PALD1 Gene

Sources for PALD1 Gene