Aliases for PAK5 Gene
Aliases for PAK5 Gene
External Ids for PAK5 Gene
- HGNC: 15916
- Entrez Gene: 57144
- Ensembl: ENSG00000101349
- OMIM: 608038
- UniProtKB: Q9P286
Previous HGNC Symbols for PAK5 Gene
- PAK7
Summaries for PAK5 Gene
-
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAK5 Gene
PAK5 (P21 (RAC1) Activated Kinase 5) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Akt Signaling. An important paralog of this gene is PAK4.
UniProtKB/Swiss-Prot for PAK5 Gene
-
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Additional gene information for PAK5 Gene
- Monarch Initiative
- Search for PAK5 at DataMed
- Search for PAK5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK5 Gene
Genomics for PAK5 Gene
GeneHancer (GH) Regulatory Elements for PAK5 Gene
Promoters and enhancers for PAK5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20I009838 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 550.8 | 0.0 | 0 | 0.5 | MXI1 ZBTB6 BACH1 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A ZNF444 | PAK5 GC20M009874 | |
| GH20I009839 | Enhancer | 0.6 | ENCODE | 550.8 | +0.4 | 362 | 0 | MXI1 BACH1 SIN3A ZIC2 ZNF335 GLIS2 POLR2A ZBTB26 ZBTB17 ZBTB20 | PAK5 GC20M009768 | |
| GH20I009919 | Enhancer | 0.4 | Ensembl | 9.5 | -80.3 | -80260 | 0.2 | IRF4 RUNX3 | PAK5 GC20M009874 ANKEF1 | |
| GH20I009833 | Enhancer | 0.3 | FANTOM5 | 7.6 | +5.7 | 5651 | 0.3 | CREB1 | PAK5 GC20M009768 | |
| GH20I010109 | Enhancer | 0.8 | FANTOM5 dbSUPER | 2.6 | -270.6 | -270552 | 0.1 | JUND ATF3 MAX ZBTB33 HNF4A REST RAD21 YY1 | PAK5 GC20M010116 ENSG00000276525 SNAP25-AS1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PAK5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PAK5 Gene
Genomic Locations for PAK5 Gene
- chr20:9,537,389-9,839,041
- (GRCh38/hg38)
- Size:
- 301,653 bases
- Orientation:
- Minus strand
- chr20:9,518,036-9,819,689
- (GRCh37/hg19)
Genomic View for PAK5 Gene
Genes around PAK5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p12.2 by Ensembl
- 20p12.2 by Entrez Gene
- 20p12.2 by HGNC
PAK5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PAK5 Gene
Proteins for PAK5 Gene
-
Protein details for PAK5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P286-PAK5_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PAK 5
- Protein Accession:
- Q9P286
- A8K5T6
- D3DW14
- Q5W115
- Q8TB93
- Q9BX09
- Q9ULF6
Protein attributes for PAK5 Gene
- Size:
- 719 amino acids
- Molecular mass:
- 80745 Da
- Quaternary structure:
-
- Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.
- SequenceCaution:
-
- Sequence=BAA86578.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Selected DME Specific Peptides for PAK5 Gene
- Q9P286:
-
- EVDIWSLG
- DFGFCAQ
- MDLRKQQRRELLFNEVVIMRDY
- KIGEGSTG
- SYLVGDELWVVME
- LEGGALTDIVTH
- WMAPEVI
- PSNFEHRVHTGFD
- VPKRKSLVGTPYWMAPEVISR
- HEQFRAALQ
- GTPYWMAPE
- QGVIHRDIKSDSILL
- EEQIATVC
Post-translational modifications for PAK5 Gene
- Autophosphorylated when activated by CDC42/p21.
Other Protein References for PAK5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PAK5 (PAK7)
- Cell Signaling Technology (CST) Antibodies for PAK5 (PAK5)
-
Custom Antibody ServicesOriGene Antibodies for PAK5
- Novus Biologicals Antibodies for PAK5
-
Abcam antibodies for PAK5
- Invitrogen Antibodies for PAK5
- Search GeneTex for Antibodies for PAK5
-
Custom Antibody ServicesProSci Antibodies for PAK5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PAK5
- Origene Custom Protein Services for PAK5
- Search GeneTex for Proteins for PAK5
-
Abcam proteins for PAK5
Assay Products
- antibodies-online: Search results for available PAK7 related products ranked by validation data
Domains & Families for PAK5 Gene
Gene Families for PAK5 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PAK5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PAK5 Gene
Graphical View of Domain Structure for InterPro Entry
Q9P286UniProtKB/Swiss-Prot:
PAK5_HUMAN :- An autoinhibitory domain is present in the N-terminal region of the protein.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Domain:
-
- An autoinhibitory domain is present in the N-terminal region of the protein.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for PAK5 Gene
Molecular function for PAK5 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Enzyme Numbers (IUBMB) for PAK5 Gene
Phenotypes From GWAS Catalog for PAK5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 20936779 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for PAK5 Gene
- MGI mutant phenotypes for PAK5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PAK5:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased mitotic index
- Decreased substrate adherent cell growth
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased Nanog expression
- Decreased telomerase activity
- Decreased Cdk9 T-loop phosphorylation
Animal Models for PAK5 Gene
- MGI Knock Outs for PAK5:
-
- Pak7 tm1Amin
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PAK5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PAK5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PAK5 gene
- Search ViGene Biosciences for PAK5
CRISPR Products
-
OriGene CRISPR knockouts for PAK5
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- Applied Biological Materials CRISPR for PAK5
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PAK5
miRNA for PAK5 Gene
- miRTarBase miRNAs that target PAK5
-
- hsa-mir-4776-3p (MIRT622925)
- hsa-mir-5006-5p (MIRT622926)
- hsa-mir-3972 (MIRT622927)
- hsa-mir-1202 (MIRT622928)
- hsa-mir-630 (MIRT622929)
- hsa-mir-548l (MIRT622930)
- hsa-mir-548n (MIRT622931)
- hsa-mir-129-5p (MIRT622932)
- hsa-mir-3682-5p (MIRT655459)
- hsa-mir-627-3p (MIRT655460)
- hsa-mir-138-1-3p (MIRT655461)
- hsa-mir-186-5p (MIRT734450)
miRNA Products
- Search ViGene Biosciences for PAK5
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PAK5
- Browse OriGene Inhibitory RNA Products For PAK5
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PAK5 gene
Clone Products
- Sino Biological Human cDNA Clone for PAK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- Applied Biological Materials Clones for PAK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PAK5
-
ViGene Biosciences adenoviral particle packaged cDNA for PAK5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PAK5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PAK5 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK5 Gene
Localization for PAK5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PAK5 Gene
- Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for PAK5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
.67
.67
|
.56
|
| 2 | fMLP Pathway |
.39
|
|
| 3 | ERK Signaling |
.61
|
.58
|
| 4 | GPCR Pathway |
.73
|
.62
|
| 5 | ErbB signaling pathway | ||
Pathways by source for PAK5 Gene
1 Cell Signaling Technology pathway for PAK5 Gene
2 BioSystems pathways for PAK5 Gene
4 Reactome pathways for PAK5 Gene
7 KEGG pathways for PAK5 Gene
1 GeneGo (Thomson Reuters) pathway for PAK5 Gene
Interacting Proteins for PAK5 Gene
Selected Interacting proteins:
ENSP00000322957
Q9P286-PAK5_HUMAN
for PAK5 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | TAS | 20070256 |
| GO:0007010 | cytoskeleton organization | TAS | 20070256 |
| GO:0007165 | signal transduction | TAS | 20070256 |
| GO:0007266 | Rho protein signal transduction | IBA | -- |
No data available for SIGNOR curated interactions for PAK5 Gene
Drugs & Compounds for PAK5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for PAK5 Gene
mRNA/cDNA for PAK5 Gene
- (8) REFSEQ mRNAs :
- (56) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PAK5
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- Applied Biological Materials CRISPR for PAK5
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PAK5
miRNA Products
- Search ViGene Biosciences for PAK5
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PAK5
- Browse OriGene Inhibitory RNA Products For PAK5
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PAK5 gene
Clone Products
- Sino Biological Human cDNA Clone for PAK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- Applied Biological Materials Clones for PAK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PAK5 Gene
NURSA nuclear receptor signaling pathways regulating expression of PAK5 Gene:
PAK5mRNA Expression by UniProt/SwissProt for PAK5 Gene:
Q9P286-PAK5_HUMAN
Tissue specificity:
Predominantly expressed in brain.
Evidence on tissue expression from TISSUES for PAK5 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for PAK5
-
OriGene qPCR primer pairs and template standards for PAK5
- genomics-online: primer clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAK5 Gene
Orthologs for PAK5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PAK7 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PAK7 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PAK7 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pak7 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pak7 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PAK7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PAK7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PAK7 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PAK7 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | PAK7 (1 of 2) 34 |
|
OneToMany | |
| pak7 33 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mbt 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pak-2 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE20 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10829 34 |
|
OneToMany |
- Species where no ortholog for PAK5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PAK5 Gene
Variants for PAK5 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs952665081 | A colorectal adenocarcinoma sample | 9,580,201(-) | A/G | coding_sequence_variant, missense_variant | |
| VAR_040982 | A lung adenocarcinoma sample | p.Thr538Asn | |||
| VAR_040984 | A metastatic melanoma sample | p.Val604Ile | |||
| VAR_040985 | A metastatic melanoma sample | p.Gly704Ser | |||
| rs1000009596 | -- | 9,757,951(-) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.93;
79.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PAK5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK5 Gene
Disorders for PAK5 Gene
Additional Disease Information for PAK5
No disorders were found for PAK5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAK5 Gene
Publications for PAK5 Gene
- Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. (PMID: 16581795) Cotteret S … Chernoff J (Molecular and cellular biology 2006) 3 4 22 58
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
- p120-catenin is a binding partner and substrate for Group B Pak kinases. (PMID: 20564219) Wong LE … Minden A (Journal of cellular biochemistry 2010) 3 4 58
- P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. (PMID: 19415746) Gong W … Zhang H (International journal of cancer 2009) 3 22 58
- PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. (PMID: 16014608) Matenia D … Mandelkow EM (Molecular biology of the cell 2005) 3 4 58
Products for PAK5 Gene
- R&D Systems Antibodies for PAK5 (PAK7)
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- Custom Antibody ServicesOriGene Antibodies for PAK5
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for PAK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PAK5
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- antibodies-online: Search results for 99 available PAK7 Antibodies ranked by validation data
- Compare Top PAK7 Antibodies
- Quality Products:
- antibodies-online: Search results for available PAK7 related products ranked by validation data
- antibodies-online: Search results for 13 available PAK7 Proteins ranked by validation data
- Compare Top PAK7 Proteins
- Search GeneTex for Antibodies for PAK5
- Search GeneTex for Proteins for PAK5
- ViGene Biosciences adenoviral particle packaged cDNA for PAK5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PAK5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PAK5 gene
- Search ViGene Biosciences for PAK5
- Custom Antibody ServicesProSci Antibodies for PAK5
- Search for PAK5 Proteins at ProSci
- Horizon Cell Lines for PAK5
- genomics-online: cdna clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- orf clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: primer clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
Sources for PAK5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew