PAK5 Gene (Protein Coding)

P21 (RAC1) Activated Kinase 5

GC20M009538
GIFtS:
37
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the... See more...

Aliases for PAK5 Gene

Aliases for PAK5 Gene

  • P21 (RAC1) Activated Kinase 5 2 3 5
  • P21 Protein (Cdc42/Rac)-Activated Kinase 7 2 3
  • Serine/Threonine-Protein Kinase PAK 5 3 4
  • P21(CDKN1A)-Activated Kinase 7 2 3
  • P21 (RAC1) Activated Kinase 7 2 3
  • P21-Activated Kinase 5 3 4
  • P21-Activated Kinase 7 3 4
  • EC 2.7.11.1 4 50
  • KIAA1264 2 4
  • PAK-5 3 4
  • PAK-7 3 4
  • PAK7 3 4
  • Serine/Threonine-Protein Kinase PAK 7 3
  • Serine/Threonine-Protein Kinase PAK7 3
  • P21CDKN1A-Activated Kinase 7 3
  • Protein Kinase PAK5 3
  • EC 2.7.11 50
  • PAK5 5

External Ids for PAK5 Gene

Previous HGNC Symbols for PAK5 Gene

  • PAK7

Summaries for PAK5 Gene

Entrez Gene Summary for PAK5 Gene

  • The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK5 Gene

PAK5 (P21 (RAC1) Activated Kinase 5) is a Protein Coding gene. Diseases associated with PAK5 include Breast Large Cell Neuroendocrine Carcinoma and Developmental And Epileptic Encephalopathy 12. Among its related pathways are Integrin Pathway and Agrin Interactions at Neuromuscular Junction. An important paralog of this gene is PAK4.

UniProtKB/Swiss-Prot Summary for PAK5 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Gene Wiki entry for PAK5 Gene

Additional gene information for PAK5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAK5 Gene

Genomics for PAK5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PAK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J009839 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.4 375 1.8 ZNF600 ZIC2 NFIC SIN3A KLF9 SP2 ZBTB48 NRF1 TAF1 LCORL PAK5 ENSG00000235036 ANKEF1 ENSG00000286470 LAMP5
GH20J009799 Promoter 0.3 EPDnew 250.3 +39.6 39611 0.1 PAK5 lnc-MKKS-8 ENSG00000286470 LAMP5
GH20J009919 Enhancer 0.4 Ensembl 9.5 -80.5 -80525 2.4 IRF4 SPI1 TCF7 RUNX3 PAK5 HSALNG0128599 HSALNG0128598 ANKEF1
GH20J009551 Enhancer 0.5 Ensembl 5.1 +287.5 287475 0.8 FEZF1 ZFP64 SPI1 OSR2 ZBTB20 LAMP5 LAMP5-AS1 PAK5 ENSG00000286740
GH20J009833 Enhancer 0.3 FANTOM5 7.6 +5.7 5686 0.3 CREB1 PAK5 ENSG00000286470 lnc-MKKS-8 LAMP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAK5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAK5

Genomic Locations for PAK5 Gene

Latest Assembly
chr20:9,537,370-9,839,076
(GRCh38/hg38)
Size:
301,707 bases
Orientation:
Minus strand

Previous Assembly
chr20:9,518,017-9,819,724
(GRCh37/hg19 by Entrez Gene)
Size:
301,708 bases
Orientation:
Minus strand

chr20:9,518,036-9,819,689
(GRCh37/hg19 by Ensembl)
Size:
301,654 bases
Orientation:
Minus strand

Genomic View for PAK5 Gene

Genes around PAK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PAK5 Gene

Proteins for PAK5 Gene

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  • Protein details for PAK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P286-PAK5_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 5
    Protein Accession:
    Q9P286
    Secondary Accessions:
    • A8K5T6
    • D3DW14
    • Q5W115
    • Q8TB93
    • Q9BX09
    • Q9ULF6

    Protein attributes for PAK5 Gene

    Size:
    719 amino acids
    Molecular mass:
    80745 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.
    SequenceCaution:
    • Sequence=BAA86578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAK5 Gene

neXtProt entry for PAK5 Gene

Selected DME Specific Peptides for PAK5 Gene

Q9P286:
  • EVDIWSLG
  • DFGFCAQ
  • MDLRKQQRRELLFNEVVIMRDY
  • KIGEGSTG
  • SYLVGDELWVVME
  • LEGGALTDIVTH
  • WMAPEVI
  • PSNFEHRVHTGFD
  • VPKRKSLVGTPYWMAPEVISR
  • HEQFRAALQ
  • GTPYWMAPE
  • QGVIHRDIKSDSILL
  • EEQIATVC

Post-translational modifications for PAK5 Gene

Other Protein References for PAK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PAK5 Gene

Gene Families for PAK5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PAK5 Gene

InterPro:
Blocks:
  • PAK-box/P21-Rho-binding

Suggested Antigen Peptide Sequences for PAK5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ38355 fis, clone FEBRA1000188, highly similar to Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (B3KTJ2_HUMAN)
  • p21-activated kinase 7 (PAK7_HUMAN)
  • p21 protein (Cdc42/Rac)-activated kinase 7 (Q8TB93_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P286

UniProtKB/Swiss-Prot:

PAK5_HUMAN :
  • An autoinhibitory domain is present in the N-terminal region of the protein.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • An autoinhibitory domain is present in the N-terminal region of the protein.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK5: view

Function for PAK5 Gene

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  6. Cell Lines for research

Molecular function for PAK5 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for PAK5 Gene

Phenotypes From GWAS Catalog for PAK5 Gene

Gene Ontology (GO) - Molecular Function for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 19060904
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PAK5: view
genes like me logo Genes that share phenotypes with PAK5: view

Animal Models for PAK5 Gene

MGI Knock Outs for PAK5:
  • Pak5 Pak5<tm1Amin>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAK5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK5 Gene

Localization for PAK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK5 Gene

Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAK5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with PAK5: view

Pathways & Interactions for PAK5 Gene

PathCards logo

SuperPathways for PAK5 Gene

SuperPathway Contained pathways
1 Integrin Pathway
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
Transendothelial Migration of Leukocytes
.38
2 fMLP Pathway
CCR3 Pathway in Eosinophils
.44
CXCR4 Pathway
.39
Internalin Pathway
.31
3 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
4 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
5 ErbB signaling pathway
ErbB signaling pathway
.49
Renal cell carcinoma
.31
genes like me logo Genes that share pathways with PAK5: view

Pathways by source for PAK5 Gene

1 Sino Biological pathway for PAK5 Gene
2 BioSystems pathways for PAK5 Gene
1 GeneGo (Thomson Reuters) pathway for PAK5 Gene
  • Cytoskeleton remodeling_Role of PDGFs in cell migration
31 Qiagen pathways for PAK5 Gene
  • Actin Nucleation and Branching
  • Actin-Based Motility by Rho Family GTPases
  • Agrin Interactions at Neuromuscular Junction
  • Angiopoietin-TIE2 Signaling
  • CCR3 Pathway in Eosinophils
1 Cell Signaling Technology pathway for PAK5 Gene

SIGNOR curated interactions for PAK5 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20070256
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
GO:0007165 signal transduction IBA,TAS 20070256
genes like me logo Genes that share ontologies with PAK5: view

Drugs & Compounds for PAK5 Gene

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  1. Drug products for research

(2) Drugs for PAK5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PAK5: view

Transcripts for PAK5 Gene

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mRNA/cDNA for PAK5 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAK5

Alternative Splicing Database (ASD) splice patterns (SP) for PAK5 Gene

No ASD Table

Relevant External Links for PAK5 Gene

GeneLoc Exon Structure for
PAK5

Expression for PAK5 Gene

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Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAK5

mRNA Expression by UniProt/SwissProt for PAK5 Gene:

Q9P286-PAK5_HUMAN
Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for PAK5 Gene

  • Nervous system(4.9)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAK5 Gene

Orthologs for PAK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PAK7 29 30
  • 99.68 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PAK7 29 30
  • 91.75 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PAK7 29 30
  • 89.62 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Pak7 29 30
  • 89.57 (n)
 OneToOne
Pak5 16
Rat
(Rattus norvegicus)
 Mammalia Pak7 29
  • 89.37 (n)
Oppossum
(Monodelphis domestica)
 Mammalia PAK7 30
  • 88 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PAK7 30
  • 84 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PAK7 29 30
  • 76.93 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PAK7 30
  • 80 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii PAK7 (1 of 2) 30
  • 90 (a)
 OneToMany
pak7 29 30
  • 65.4 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta mbt 30
  • 50 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea pak-2 29 30
  • 54.54 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STE20 30
  • 22 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10829 30
  • 45 (a)
 OneToMany
Species where no ortholog for PAK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PAK5 Gene

ENSEMBL:
Gene Tree for PAK5 (if available)
TreeFam:
Gene Tree for PAK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAK5: view image
Alliance of Genome Resources:
Additional Orthologs for PAK5

Paralogs for PAK5 Gene

Variants for PAK5 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAK5 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs115731613 Benign: not provided 9,580,619(-) T/C
NM_020341.4(PAK5):c.516A>G (p.Val172=) 		SYNONYMOUS
rs148469155 A metastatic melanoma sample p.Gly704Ser
rs56054068 Benign: not provided 9,580,487(-) C/T
NM_020341.4(PAK5):c.648G>A (p.Lys216=) 		SYNONYMOUS
rs61729218 Benign: not provided 9,566,376(-) G/A
NM_020341.4(PAK5):c.999C>T (p.Tyr333=) 		SYNONYMOUS
rs75316826 Benign: not provided 9,544,431(-) A/G
NM_020341.4(PAK5):c.1807T>C (p.Leu603=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PAK5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PAK5 Gene

Variant ID Type Subtype PubMed ID
dgv1227e212 CNV gain 25503493
dgv4243n100 CNV gain 25217958
dgv85n6 CNV deletion 16902084
esv1107872 CNV insertion 17803354
esv1680592 CNV insertion 17803354
esv1922572 CNV deletion 18987734
esv2658643 CNV deletion 23128226
esv2664724 CNV deletion 23128226
esv2676789 CNV deletion 23128226
esv2722168 CNV deletion 23290073
esv2722169 CNV deletion 23290073
esv2722170 CNV deletion 23290073
esv2722171 CNV deletion 23290073
esv3307148 CNV mobile element insertion 20981092
esv3309512 CNV mobile element insertion 20981092
esv3322147 CNV insertion 20981092
esv3335505 CNV insertion 20981092
esv3352433 CNV insertion 20981092
esv3355413 CNV insertion 20981092
esv3404259 CNV insertion 20981092
esv3428868 CNV insertion 20981092
esv3556813 CNV deletion 23714750
esv3556814 CNV deletion 23714750
esv3645194 CNV loss 21293372
esv3645195 CNV loss 21293372
esv3645196 CNV loss 21293372
nsv1060206 CNV gain 25217958
nsv1072104 CNV deletion 25765185
nsv1072523 CNV deletion 25765185
nsv1136505 CNV deletion 24896259
nsv1138920 CNV deletion 24896259
nsv458867 CNV loss 19166990
nsv472714 CNV novel sequence insertion 20440878
nsv517670 CNV loss 19592680
nsv521694 CNV loss 19592680
nsv522383 CNV loss 19592680
nsv524114 CNV gain 19592680
nsv585411 CNV gain 21841781
nsv585412 CNV loss 21841781
nsv585413 CNV gain 21841781

Variation tolerance for PAK5 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAK5 Gene

Human Gene Mutation Database (HGMD)
PAK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAK5
Leiden Open Variation Database (LOVD)
PAK5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK5 Gene

Disorders for PAK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAK5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search PAK5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PAK5

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PAK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAK5 Gene

Publications for PAK5 Gene

  1. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. (PMID: 16581795) Cotteret S … Chernoff J (Molecular and cellular biology 2006) 3 4 22
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  3. p120-catenin is a binding partner and substrate for Group B Pak kinases. (PMID: 20564219) Wong LE … Minden A (Journal of cellular biochemistry 2010) 3 4
  4. P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. (PMID: 19415746) Gong W … Zhang H (International journal of cancer 2009) 3 22
  5. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. (PMID: 16014608) Matenia D … Mandelkow EM (Molecular biology of the cell 2005) 3 4

ExternalLinks

View latest publications for PAK5 gene in Mastermind

Products for PAK5 Gene

  • Addgene plasmids for PAK5

Sources for PAK5 Gene