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The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
PAK5 (P21 (RAC1) Activated Kinase 5) is a Protein Coding gene. Diseases associated with PAK5 include Breast Large Cell Neuroendocrine Carcinoma and Epileptic Encephalopathy, Early Infantile, 12. Among its related pathways are Integrin Pathway and Guidance Cues and Growth Cone Motility. An important paralog of this gene is PAK4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20J009839 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.3 | 275 | 2 | PRDM10 KDM1A ZIC2 ZSCAN4 POLR2A EZH2 ZNF600 ZBTB44 KLF9 ZBTB20 | PAK5 ENSG00000235036 ANKEF1 ENSG00000286470 LAMP5 | |
GH20J009799 | Promoter | 0.3 | EPDnew | 600.3 | +39.6 | 39611 | 0.1 | PAK5 lnc-MKKS-8 ENSG00000286470 LAMP5 | ||
GH20J009928 | Enhancer | 0.6 | Ensembl | 8.8 | -89.3 | -89325 | 0.8 | JUND IKZF2 EED ARID3A RUNX3 BCLAF1 CBFB BCL11A JUNB IRF4 | PAK5 lnc-ANKEF1-5 RF00876-011 ANKEF1 | |
GH20J009919 | Enhancer | 0.5 | Ensembl | 9.5 | -80.5 | -80525 | 2.4 | RCOR1 RUNX3 SPI1 IRF4 TCF7 | PAK5 lnc-ANKEF1-5 RF00876-011 ANKEF1 | |
GH20J009551 | Enhancer | 0.5 | Ensembl | 5.1 | +287.5 | 287475 | 0.8 | ZBTB20 OSR2 SPI1 FEZF1 ZFP64 | LAMP5 LAMP5-AS1 PAK5 ENSG00000286740 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19060904 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
|
GnRH Signaling
.56
Transendothelial Migration of Leukocytes
.38
|
2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
CXCR4 Pathway
.39
|
Internalin Pathway
.31
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
|
4 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
|
GPCR Pathway
.62
|
5 | ErbB signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | TAS | 20070256 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006915 | apoptotic process | TAS | 20070256 |
GO:0007010 | cytoskeleton organization | TAS | 20070256 |
GO:0007165 | signal transduction | TAS | 20070256 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PAK7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PAK7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PAK7 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pak7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pak7 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PAK7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PAK7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PAK7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PAK7 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | PAK7 (1 of 2) 31 |
|
OneToMany | |
pak7 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | mbt 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | pak-2 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE20 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10829 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769076 | Benign: not provided | 9,566,376(-) | G/A | SYNONYMOUS_VARIANT | |
769077 | Benign: not provided | 9,580,487(-) | C/T | SYNONYMOUS_VARIANT | |
786363 | Benign: not provided | 9,544,431(-) | A/G | SYNONYMOUS_VARIANT | |
790215 | Benign: not provided | 9,580,619(-) | T/C | SYNONYMOUS_VARIANT | |
rs1484691555 | A metastatic melanoma sample | p.Gly704Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast large cell neuroendocrine carcinoma |
|
|
epileptic encephalopathy, early infantile, 12 |
|
|