Aliases for PAK5 Gene
Aliases for PAK5 Gene
External Ids for PAK5 Gene
- HGNC: 15916
- Entrez Gene: 57144
- Ensembl: ENSG00000101349
- OMIM: 608038
- UniProtKB: Q9P286
Previous HGNC Symbols for PAK5 Gene
- PAK7
Summaries for PAK5 Gene
-
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAK5 Gene
PAK5 (P21 (RAC1) Activated Kinase 5) is a Protein Coding gene. Among its related pathways are Focal Adhesion and T cell receptor signaling pathway. An important paralog of this gene is PAK4.
UniProtKB/Swiss-Prot for PAK5 Gene
-
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Additional gene information for PAK5 Gene
- Monarch Initiative
- Search for PAK5 at DataMed
- Search for PAK5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK5 Gene
Genomics for PAK5 Gene
GeneHancer (GH) Regulatory Elements for PAK5 Gene
Promoters and enhancers for PAK5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20J009838 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 650.7 | 0.0 | 0 | 0.5 | MXI1 ZBTB6 BACH1 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A ZNF444 | PAK5 GC20M009874 | |
| GH20J009839 | Enhancer | 0.6 | ENCODE | 650.7 | +0.4 | 362 | 0 | MXI1 BACH1 SIN3A ZIC2 ZNF335 GLIS2 POLR2A ZBTB26 ZBTB17 ZBTB20 | PAK5 GC20M009768 | |
| GH20J009799 | Promoter | 0.5 | EPDnew | 650.3 | +39.6 | 39576 | 0.1 | PAK5 GC20M009768 | ||
| GH20J009919 | Enhancer | 0.4 | Ensembl | 9.5 | -80.3 | -80260 | 0.2 | IRF4 RUNX3 | PAK5 GC20M009874 PARAL1 | |
| GH20J009833 | Enhancer | 0.3 | FANTOM5 | 7.6 | +5.7 | 5651 | 0.3 | CREB1 | PAK5 GC20M009768 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PAK5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PAK5 Gene
Genomic Locations for PAK5 Gene
- chr20:9,537,389-9,839,041
- (GRCh38/hg38)
- Size:
- 301,653 bases
- Orientation:
- Minus strand
- chr20:9,518,036-9,819,689
- (GRCh37/hg19)
- Size:
- 301,654 bases
- Orientation:
- Minus strand
Genomic View for PAK5 Gene
Genes around PAK5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p12.2 by Entrez Gene
- 20p12.2 by HGNC
- 20p12.2 by Ensembl
PAK5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PAK5 Gene
Proteins for PAK5 Gene
-
Protein details for PAK5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P286-PAK5_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PAK 5
- Protein Accession:
- Q9P286
- A8K5T6
- D3DW14
- Q5W115
- Q8TB93
- Q9BX09
- Q9ULF6
Protein attributes for PAK5 Gene
- Size:
- 719 amino acids
- Molecular mass:
- 80745 Da
- Quaternary structure:
-
- Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.
- SequenceCaution:
-
- Sequence=BAA86578.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for PAK5 Gene
- Autophosphorylated when activated by CDC42/p21.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PAK5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PAK5 (PAK7)
-
Custom Antibody ServicesOriGene Antibodies for PAK5
- Novus Biologicals Antibodies for PAK5
-
Abcam antibodies for PAK5
- Invitrogen Antibodies for PAK5
- GeneTex PAK5 Antibody for PAK5
-
Boster Bio Antibodies for PAK5
-
Custom Antibody ServicesProSci Antibodies for PAK5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PAK5
- Origene Custom Protein Services for PAK5
- GeneTex Proteins for PAK5
-
Abcam proteins for PAK5
Assay Products
- antibodies-online: Search results for available PAK7 related products ranked by validation data
No data available for DME Specific Peptides for PAK5 Gene
Domains & Families for PAK5 Gene
Gene Families for PAK5 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PAK5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PAK5 Gene
Graphical View of Domain Structure for InterPro Entry
Q9P286UniProtKB/Swiss-Prot:
PAK5_HUMAN :- An autoinhibitory domain is present in the N-terminal region of the protein.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Domain:
-
- An autoinhibitory domain is present in the N-terminal region of the protein.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for PAK5 Gene
Molecular function for PAK5 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
Enzyme Numbers (IUBMB) for PAK5 Gene
Phenotypes From GWAS Catalog for PAK5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 20936779 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for PAK5 Gene
- MGI mutant phenotypes for PAK5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PAK5:
-
- Increased mitotic index
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Decreased telomerase activity
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased ionizing radiation sensitivity
- Increased Nanog expression
- no effect
- Decreased Cdk9 T-loop phosphorylation
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for PAK5 Gene
- MGI Knock Outs for PAK5:
-
- Pak7 Pak7<tm1Amin>
Animal Model Products
-
Taconic Biosciences Mouse Models for PAK5
- Cyagen custom Knockout/knockin (KOKI) mouse models for PAK5
-
CRISPR Products
-
OriGene CRISPR knockouts for PAK5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PAK5
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- Applied Biological Materials CRISPR for PAK5
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PAK5
miRNA for PAK5 Gene
- miRTarBase miRNAs that target PAK5
-
- hsa-mir-4776-3p (MIRT622925)
- hsa-mir-5006-5p (MIRT622926)
- hsa-mir-3972 (MIRT622927)
- hsa-mir-1202 (MIRT622928)
- hsa-mir-630 (MIRT622929)
- hsa-mir-548l (MIRT622930)
- hsa-mir-548n (MIRT622931)
- hsa-mir-129-5p (MIRT622932)
- hsa-mir-3682-5p (MIRT655459)
- hsa-mir-627-3p (MIRT655460)
- hsa-mir-138-1-3p (MIRT655461)
- hsa-mir-186-5p (MIRT734450)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PAK5
- Browse OriGene Inhibitory RNA Products For PAK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAK5
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PAK5
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PAK5
- Applied Biological Materials Clones for PAK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PAK5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK5 Gene
Localization for PAK5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PAK5 Gene
- Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for PAK5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
.67
.67
|
.56
|
| 2 | fMLP Pathway |
.39
|
|
| 3 | ERK Signaling |
.61
|
.58
|
| 4 | GPCR Pathway |
.73
|
.62
|
| 5 | ErbB signaling pathway | ||
Pathways by source for PAK5 Gene
2 BioSystems pathways for PAK5 Gene
4 Reactome pathways for PAK5 Gene
7 KEGG pathways for PAK5 Gene
1 GeneGo (Thomson Reuters) pathway for PAK5 Gene
31 Qiagen pathways for PAK5 Gene
1 Cell Signaling Technology pathway for PAK5 Gene
Interacting Proteins for PAK5 Gene
Selected Interacting proteins:
Q9P286-PAK5_HUMAN
ENSP00000322957
for PAK5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PAK5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | TAS | 20070256 |
| GO:0007010 | cytoskeleton organization | TAS | 20070256 |
| GO:0007165 | signal transduction | TAS | 20070256 |
| GO:0007266 | Rho protein signal transduction | IBA | -- |
No data available for SIGNOR curated interactions for PAK5 Gene
Transcripts for PAK5 Gene
mRNA/cDNA for PAK5 Gene
- (8) REFSEQ mRNAs :
- (4) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000378423 4613 bps (uc002wnj.3)
- ENST00000353224 4500 bps (uc002wnk.3)
- ENST00000378429 4780 bps (uc002wnl.3)
CRISPR Products
-
OriGene CRISPR knockouts for PAK5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PAK5
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- Applied Biological Materials CRISPR for PAK5
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PAK5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PAK5
- Browse OriGene Inhibitory RNA Products For PAK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAK5
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PAK5
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PAK5
- Applied Biological Materials Clones for PAK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PAK5 Gene
NURSA nuclear receptor signaling pathways regulating expression of PAK5 Gene:
PAK5mRNA Expression by UniProt/SwissProt for PAK5 Gene:
Q9P286-PAK5_HUMAN
Tissue specificity:
Predominantly expressed in brain.
Evidence on tissue expression from TISSUES for PAK5 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs and template standards for PAK5
-
OriGene qPCR primer pairs for PAK5
- genomics-online: primer clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAK5 Gene
Orthologs for PAK5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PAK7 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PAK7 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PAK7 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pak7 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pak7 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PAK7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PAK7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PAK7 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PAK7 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | PAK7 (1 of 2) 34 |
|
OneToMany | |
| pak7 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | mbt 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pak-2 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE20 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10829 34 |
|
OneToMany |
- Species where no ortholog for PAK5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for PAK5 Gene
- ENSEMBL:
- Gene Tree for PAK5 (if available)
- TreeFam:
- Gene Tree for PAK5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PAK5: view image
Paralogs for PAK5 Gene
Variants for PAK5 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs952665081 | A colorectal adenocarcinoma sample | 9,580,201(-) | A/G | coding_sequence_variant, missense_variant | |
| VAR_040982 | A lung adenocarcinoma sample | p.Thr538Asn | |||
| VAR_040984 | A metastatic melanoma sample | p.Val604Ile | |||
| VAR_040985 | A metastatic melanoma sample | p.Gly704Ser | |||
| rs1000009596 | -- | 9,757,951(-) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.93;
79.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PAK5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK5 Gene
Disorders for PAK5 Gene
Additional Disease Information for PAK5
No disorders were found for PAK5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAK5 Gene
Publications for PAK5 Gene
- Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. (PMID: 16581795) Cotteret S … Chernoff J (Molecular and cellular biology 2006) 3 4 22 58
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
- p120-catenin is a binding partner and substrate for Group B Pak kinases. (PMID: 20564219) Wong LE … Minden A (Journal of cellular biochemistry 2010) 3 4 58
- P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. (PMID: 19415746) Gong W … Zhang H (International journal of cancer 2009) 3 22 58
- PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. (PMID: 16014608) Matenia D … Mandelkow EM (Molecular biology of the cell 2005) 3 4 58
Products for PAK5 Gene
- R&D Systems Antibodies for PAK5 (PAK7)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PAK5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PAK5
- Origene Custom Protein Services for PAK5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PAK5
- Browse OriGene Inhibitory RNA Products For PAK5
- OriGene qPCR primer pairs and template standards for PAK5
- OriGene qPCR primer pairs for PAK5
- OriGene CRISPR knockouts for PAK5
- OriGene ORF clones in human for PAK5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PAK5
- GenScript: Next-day shipping of latest version cDNA ORF clones for PAK5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PAK5
- GenScript Custom Assay Services for PAK5
- GenScript Custom overexpressing Cell Line Services for PAK5
- GenScript: Design CRISPR guide RNA sequences for PAK5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PAK5
- Sino Biological Human cDNA Clone for PAK5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PAK5
- Novus Biologicals lysates and proteins for PAK5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PAK5
- Abcam proteins for PAK5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PAK5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PAK5
- Cyagen custom Knockout/knockin (KOKI) mouse models for PAK5
- VectorBuilder custom plasmid, inducible vectors for PAK5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PAK5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PAK5
- antibodies-online: Search results for 99 available PAK7 Antibodies ranked by validation data
- Compare Top PAK7 Antibodies
- Quality Products:
- antibodies-online: Search results for available PAK7 related products ranked by validation data
- antibodies-online: Search results for 13 available PAK7 Proteins ranked by validation data
- Compare Top PAK7 Proteins
- GeneTex PAK5 Antibody for PAK5
- GeneTex Proteins for PAK5
- Custom Antibody ServicesProSci Antibodies for PAK5
- Search for PAK5 Proteins at ProSci
- Horizon Cell Lines for PAK5
- genomics-online: cdna clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- orf clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: gRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: primer clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- genomics-online: shRNA clones - Search results for 129 available PAK7 gene related products
- Overview of 129 available PAK7 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PAK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PAK5
- GeneCopoeia miRNA 3'UTR Target clone products for PAK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAK5
- Boster Bio Antibodies for PAK5
- Browse Boster Bio ELISA Kits
Sources for PAK5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt