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Aliases for PAK5 Gene

Aliases for PAK5 Gene

  • P21 (RAC1) Activated Kinase 5 2 3 5
  • P21 Protein (Cdc42/Rac)-Activated Kinase 7 2 3
  • P21(CDKN1A)-Activated Kinase 7 2 3
  • P21 (RAC1) Activated Kinase 7 2 3
  • P21-Activated Kinase 5 3 4
  • P21-Activated Kinase 7 3 4
  • PAK-5 3 4
  • PAK-7 3 4
  • PAK7 3 4
  • Serine/Threonine-Protein Kinase PAK 5 3
  • Serine/Threonine-Protein Kinase PAK 7 3
  • Serine/Threonine-Protein Kinase PAK7 3
  • P21CDKN1A-Activated Kinase 7 3
  • Protein Kinase PAK5 3
  • EC 2.7.11.1 4
  • KIAA1264 4

External Ids for PAK5 Gene

Previous HGNC Symbols for PAK5 Gene

  • PAK7

Summaries for PAK5 Gene

Entrez Gene Summary for PAK5 Gene

  • The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAK5 Gene

PAK5 (P21 (RAC1) Activated Kinase 5) is a Protein Coding gene. Among its related pathways are Focal Adhesion and T cell receptor signaling pathway. An important paralog of this gene is PAK4.

UniProtKB/Swiss-Prot for PAK5 Gene

  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Gene Wiki entry for PAK5 Gene

Additional gene information for PAK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK5 Gene

Genomics for PAK5 Gene

GeneHancer (GH) Regulatory Elements for PAK5 Gene

Promoters and enhancers for PAK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J009838 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 0.0 0 0.5 MXI1 ZBTB6 BACH1 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A ZNF444 PAK5 GC20M009874
GH20J009839 Enhancer 0.6 ENCODE 650.7 +0.4 362 0 MXI1 BACH1 SIN3A ZIC2 ZNF335 GLIS2 POLR2A ZBTB26 ZBTB17 ZBTB20 PAK5 GC20M009768
GH20J009799 Promoter 0.5 EPDnew 650.3 +39.6 39576 0.1 PAK5 GC20M009768
GH20J009919 Enhancer 0.4 Ensembl 9.5 -80.3 -80260 0.2 IRF4 RUNX3 PAK5 GC20M009874 PARAL1
GH20J009833 Enhancer 0.3 FANTOM5 7.6 +5.7 5651 0.3 CREB1 PAK5 GC20M009768
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAK5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PAK5 Gene

Genomic Locations for PAK5 Gene
chr20:9,537,389-9,839,041
(GRCh38/hg38)
Size:
301,653 bases
Orientation:
Minus strand
chr20:9,518,036-9,819,689
(GRCh37/hg19)
Size:
301,654 bases
Orientation:
Minus strand

Genomic View for PAK5 Gene

Genes around PAK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK5 Gene

Proteins for PAK5 Gene

  • Protein details for PAK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P286-PAK5_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 5
    Protein Accession:
    Q9P286
    Secondary Accessions:
    • A8K5T6
    • D3DW14
    • Q5W115
    • Q8TB93
    • Q9BX09
    • Q9ULF6

    Protein attributes for PAK5 Gene

    Size:
    719 amino acids
    Molecular mass:
    80745 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with MARK2, leading to inhibit MARK2 independently of kinase activity. Interacts with RHOD and RHOH.
    SequenceCaution:
    • Sequence=BAA86578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PAK5 Gene

neXtProt entry for PAK5 Gene

Post-translational modifications for PAK5 Gene

No data available for DME Specific Peptides for PAK5 Gene

Domains & Families for PAK5 Gene

Gene Families for PAK5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9P286

UniProtKB/Swiss-Prot:

PAK5_HUMAN :
  • An autoinhibitory domain is present in the N-terminal region of the protein.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • An autoinhibitory domain is present in the N-terminal region of the protein.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with PAK5: view

Function for PAK5 Gene

Molecular function for PAK5 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PAK5 Gene

Phenotypes From GWAS Catalog for PAK5 Gene

Gene Ontology (GO) - Molecular Function for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 20936779
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PAK5: view
genes like me logo Genes that share phenotypes with PAK5: view

Animal Models for PAK5 Gene

MGI Knock Outs for PAK5:
  • Pak7 Pak7<tm1Amin>

Animal Model Products

  • Taconic Biosciences Mouse Models for PAK5

Clone Products

  • Addgene plasmids for PAK5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAK5 Gene

Localization for PAK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK5 Gene

Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAK5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PAK5: view

Pathways & Interactions for PAK5 Gene

genes like me logo Genes that share pathways with PAK5: view

Gene Ontology (GO) - Biological Process for PAK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
GO:0007165 signal transduction TAS 20070256
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with PAK5: view

No data available for SIGNOR curated interactions for PAK5 Gene

Drugs & Compounds for PAK5 Gene

(2) Drugs for PAK5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PAK5: view

Transcripts for PAK5 Gene

mRNA/cDNA for PAK5 Gene

(8) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for PAK5

Alternative Splicing Database (ASD) splice patterns (SP) for PAK5 Gene

No ASD Table

Relevant External Links for PAK5 Gene

GeneLoc Exon Structure for
PAK5
ECgene alternative splicing isoforms for
PAK5

Expression for PAK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAK5 Gene:

PAK5

mRNA Expression by UniProt/SwissProt for PAK5 Gene:

Q9P286-PAK5_HUMAN
Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for PAK5 Gene

  • Nervous system(4.9)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAK5 Gene

Orthologs for PAK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK7 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PAK7 34 33
  • 91.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PAK7 34 33
  • 89.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pak7 16 34 33
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Pak7 33
  • 89.37 (n)
oppossum
(Monodelphis domestica)
Mammalia PAK7 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAK7 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAK7 34 33
  • 76.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAK7 34
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PAK7 (1 of 2) 34
  • 90 (a)
OneToMany
pak7 34 33
  • 65.4 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mbt 34
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pak-2 34 33
  • 54.54 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE20 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10829 34
  • 45 (a)
OneToMany
Species where no ortholog for PAK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAK5 Gene

ENSEMBL:
Gene Tree for PAK5 (if available)
TreeFam:
Gene Tree for PAK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAK5: view image

Paralogs for PAK5 Gene

Paralogs for PAK5 Gene

genes like me logo Genes that share paralogs with PAK5: view

Variants for PAK5 Gene

Sequence variations from dbSNP and Humsavar for PAK5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs952665081 A colorectal adenocarcinoma sample 9,580,201(-) A/G coding_sequence_variant, missense_variant
VAR_040982 A lung adenocarcinoma sample p.Thr538Asn
VAR_040984 A metastatic melanoma sample p.Val604Ile
VAR_040985 A metastatic melanoma sample p.Gly704Ser
rs1000009596 -- 9,757,951(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAK5 Gene

Variant ID Type Subtype PubMed ID
dgv1227e212 CNV gain 25503493
dgv4243n100 CNV gain 25217958
dgv85n6 CNV deletion 16902084
esv1107872 CNV insertion 17803354
esv1680592 CNV insertion 17803354
esv1922572 CNV deletion 18987734
esv2658643 CNV deletion 23128226
esv2664724 CNV deletion 23128226
esv2676789 CNV deletion 23128226
esv2722168 CNV deletion 23290073
esv2722169 CNV deletion 23290073
esv2722170 CNV deletion 23290073
esv2722171 CNV deletion 23290073
esv3307148 CNV mobile element insertion 20981092
esv3309512 CNV mobile element insertion 20981092
esv3322147 CNV insertion 20981092
esv3335505 CNV insertion 20981092
esv3352433 CNV insertion 20981092
esv3355413 CNV insertion 20981092
esv3404259 CNV insertion 20981092
esv3428868 CNV insertion 20981092
esv3556813 CNV deletion 23714750
esv3556814 CNV deletion 23714750
esv3645194 CNV loss 21293372
esv3645195 CNV loss 21293372
esv3645196 CNV loss 21293372
nsv1060206 CNV gain 25217958
nsv1072104 CNV deletion 25765185
nsv1072523 CNV deletion 25765185
nsv1136505 CNV deletion 24896259
nsv1138920 CNV deletion 24896259
nsv458867 CNV loss 19166990
nsv472714 CNV novel sequence insertion 20440878
nsv517670 CNV loss 19592680
nsv521694 CNV loss 19592680
nsv522383 CNV loss 19592680
nsv524114 CNV gain 19592680
nsv585411 CNV gain 21841781
nsv585412 CNV loss 21841781
nsv585413 CNV gain 21841781

Variation tolerance for PAK5 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAK5 Gene

Human Gene Mutation Database (HGMD)
PAK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAK5 Gene

Disorders for PAK5 Gene

Additional Disease Information for PAK5

No disorders were found for PAK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAK5 Gene

Publications for PAK5 Gene

  1. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. (PMID: 16581795) Cotteret S … Chernoff J (Molecular and cellular biology 2006) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. p120-catenin is a binding partner and substrate for Group B Pak kinases. (PMID: 20564219) Wong LE … Minden A (Journal of cellular biochemistry 2010) 3 4 58
  4. P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. (PMID: 19415746) Gong W … Zhang H (International journal of cancer 2009) 3 22 58
  5. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. (PMID: 16014608) Matenia D … Mandelkow EM (Molecular biology of the cell 2005) 3 4 58

Products for PAK5 Gene

Sources for PAK5 Gene

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