Aliases for PAK1IP1 Gene
External Ids for PAK1IP1 Gene
Previous GeneCards Identifiers for PAK1IP1 Gene
GeneCards Summary for PAK1IP1 Gene
PAK1IP1 (PAK1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with PAK1IP1 include Robinow Syndrome, Autosomal Dominant 1 and Robinow Syndrome. Among its related pathways are PAK Pathway. An important paralog of this gene is WDR5.
UniProtKB/Swiss-Prot Summary for PAK1IP1 Gene
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).