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Aliases for PAIP2B Gene

Aliases for PAIP2B Gene

  • Poly(A) Binding Protein Interacting Protein 2B 2 3 5
  • PABP-Interacting Protein 2B 3 4
  • PAIP-2B 3 4
  • Polyadenylate-Binding Protein-Interacting Protein 2B 3
  • Poly(A)-Binding Protein-Interacting Protein 2B 4
  • KIAA1155 4

External Ids for PAIP2B Gene

Previous GeneCards Identifiers for PAIP2B Gene

  • GC02M071264
  • GC02M071409
  • GC02M071146

Summaries for PAIP2B Gene

Entrez Gene Summary for PAIP2B Gene

  • Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PAIP2B Gene

PAIP2B (Poly(A) Binding Protein Interacting Protein 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include translation repressor activity, mRNA regulatory element binding. An important paralog of this gene is PAIP2.

UniProtKB/Swiss-Prot for PAIP2B Gene

  • Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Additional gene information for PAIP2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP2B Gene

Genomics for PAIP2B Gene

GeneHancer (GH) Regulatory Elements for PAIP2B Gene

Promoters and enhancers for PAIP2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J071226 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.9 +0.1 80 1.9 HDGF PKNOX1 ATF1 FOXA2 SIN3A FEZF1 GLI4 ZNF2 ZBTB7B IRF4 PAIP2B TEX261 TIA1 ANKRD53 MPHOSPH10 CLEC4F ZNF638 ENSG00000233870
GH02J071275 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8 -50.0 -49994 2.4 ARID4B SIN3A GLI4 ZNF2 ZNF48 YY1 SLC30A9 ZNF121 GLIS2 ZNF143 ZNF638 LOC105374797 CLEC4F TEX261 CD207 PAIP2B OR7E91P ENSG00000281195
GH02J071331 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.8 -105.6 -105572 3.2 HDGF PKNOX1 FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF638 TEX261 CD207 CLEC4F PAIP2B OR7E91P ENSG00000281195
GH02J071448 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 -227.0 -226987 10.3 FOXA2 PKNOX1 SIN3A YY1 ETS1 TCF12 ZFP91 FOS ATF7 ZNF263 DYSF CLEC4F ZNF638 RNU6-105P TEX261 ANKRD53 PAIP2B OR7E91P NAGK GC02P071578
GH02J071501 Enhancer 1.2 VISTA Ensembl ENCODE dbSUPER 5.1 -277.2 -277153 5 NCOA3 NFIB ZIK1 MZF1 ZNF491 GABPA NR2F2 ZFHX2 NFIC LCORL DYSF ZNF638 ENSG00000233870 PAIP2B GC02P071578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAIP2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAIP2B gene promoter:
  • FOXO4
  • NF-Y
  • CBF(2)
  • AML1a
  • Pbx1a
  • MAZR
  • PPAR-gamma2
  • PPAR-gamma1
  • HNF-1A
  • HNF-1

Genomic Locations for PAIP2B Gene

Genomic Locations for PAIP2B Gene
44,377 bases
Minus strand
44,366 bases
Minus strand

Genomic View for PAIP2B Gene

Genes around PAIP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP2B Gene

Proteins for PAIP2B Gene

  • Protein details for PAIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polyadenylate-binding protein-interacting protein 2B
    Protein Accession:

    Protein attributes for PAIP2B Gene

    123 amino acids
    Molecular mass:
    14237 Da
    Quaternary structure:
    • Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).
    • Sequence=BAA86469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PAIP2B Gene

Post-translational modifications for PAIP2B Gene

Other Protein References for PAIP2B Gene

No data available for DME Specific Peptides for PAIP2B Gene

Domains & Families for PAIP2B Gene

Gene Families for PAIP2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAIP2B Gene


Suggested Antigen Peptide Sequences for PAIP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PAIP2 family.
  • Belongs to the PAIP2 family.
genes like me logo Genes that share domains with PAIP2B: view

Function for PAIP2B Gene

Molecular function for PAIP2B Gene

UniProtKB/Swiss-Prot Function:
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Phenotypes From GWAS Catalog for PAIP2B Gene

Gene Ontology (GO) - Molecular Function for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IDA 16804161
GO:0005515 protein binding IPI 16804161
genes like me logo Genes that share ontologies with PAIP2B: view
genes like me logo Genes that share phenotypes with PAIP2B: view

Animal Models for PAIP2B Gene

MGI Knock Outs for PAIP2B:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAIP2B Gene

Localization for PAIP2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAIP2B gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 16804161
genes like me logo Genes that share ontologies with PAIP2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PAIP2B Gene

Pathways & Interactions for PAIP2B Gene

SuperPathways for PAIP2B Gene

No Data Available

Interacting Proteins for PAIP2B Gene

Gene Ontology (GO) - Biological Process for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0045947 negative regulation of translational initiation IDA 16804161
genes like me logo Genes that share ontologies with PAIP2B: view

No data available for Pathways by source and SIGNOR curated interactions for PAIP2B Gene

Drugs & Compounds for PAIP2B Gene

No Compound Related Data Available

Transcripts for PAIP2B Gene

mRNA/cDNA for PAIP2B Gene

Unigene Clusters for PAIP2B Gene

Poly(A) binding protein interacting protein 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2B Gene

No ASD Table

Relevant External Links for PAIP2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAIP2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAIP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAIP2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.6), Brain - Substantia nigra (x5.2), Brain - Amygdala (x4.6), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for PAIP2B Gene

This gene is overexpressed in Skin (57.1) and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAIP2B Gene

Protein tissue co-expression partners for PAIP2B Gene

NURSA nuclear receptor signaling pathways regulating expression of PAIP2B Gene:


SOURCE GeneReport for Unigene cluster for PAIP2B Gene:


mRNA Expression by UniProt/SwissProt for PAIP2B Gene:

Tissue specificity: Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.

Evidence on tissue expression from TISSUES for PAIP2B Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PAIP2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAIP2B Gene

Orthologs for PAIP2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAIP2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PAIP2B 34 33
  • 99.46 (n)
(Bos Taurus)
Mammalia PAIP2B 34 33
  • 93.22 (n)
(Canis familiaris)
Mammalia LOC475800 33
  • 91.87 (n)
  • 66 (a)
(Mus musculus)
Mammalia Paip2b 16 34 33
  • 89.16 (n)
(Rattus norvegicus)
Mammalia Paip2b 33
  • 89.16 (n)
(Monodelphis domestica)
Mammalia PAIP2B 34
  • 72 (a)
(Anolis carolinensis)
Reptilia PAIP2B 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia paip2b 33
  • 78.59 (n)
(Danio rerio)
Actinopterygii paip2b 34 33
  • 69.95 (n)
Species where no ortholog for PAIP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP2B Gene

Gene Tree for PAIP2B (if available)
Gene Tree for PAIP2B (if available)
Evolutionary constrained regions (ECRs) for PAIP2B: view image

Paralogs for PAIP2B Gene

Paralogs for PAIP2B Gene

(1) SIMAP similar genes for PAIP2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAIP2B: view

Variants for PAIP2B Gene

Sequence variations from dbSNP and Humsavar for PAIP2B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000012521 -- 71,188,740(-) G/A intron_variant
rs1000051067 -- 71,216,067(-) T/G intron_variant
rs1000080458 -- 71,216,422(-) T/C intron_variant
rs1000162436 -- 71,215,470(-) T/C intron_variant
rs1000305403 -- 71,223,289(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAIP2B Gene

Variant ID Type Subtype PubMed ID
esv2720185 CNV deletion 23290073
nsv1127733 CNV deletion 24896259
nsv508148 CNV deletion 20534489
nsv834256 CNV gain 17160897
nsv963618 CNV duplication 23825009

Variation tolerance for PAIP2B Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAIP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAIP2B Gene

Disorders for PAIP2B Gene

Additional Disease Information for PAIP2B

No disorders were found for PAIP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP2B Gene

Publications for PAIP2B Gene

  1. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PMID: 16804161) Berlanga JJ … Sonenberg N (RNA (New York, N.Y.) 2006) 2 3 4 58
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  3. Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. (PMID: 28470677) Tang H … Li D (International journal of cancer 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PAIP2B Gene

Sources for PAIP2B Gene

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