Aliases for PAIP2B Gene
External Ids for PAIP2B Gene
Previous GeneCards Identifiers for PAIP2B Gene
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PAIP2B Gene
PAIP2B (Poly(A) Binding Protein Interacting Protein 2B) is a Protein Coding gene. Diseases associated with PAIP2B include Cone-Rod Dystrophy 17 and Retinitis Pigmentosa 63. Gene Ontology (GO) annotations related to this gene include translation repressor activity, mRNA regulatory element binding. An important paralog of this gene is PAIP2.
UniProtKB/Swiss-Prot Summary for PAIP2B Gene
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.