Aliases for PAIP2B Gene
External Ids for PAIP2B Gene
Previous GeneCards Identifiers for PAIP2B Gene
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PAIP2B Gene
PAIP2B (Poly(A) Binding Protein Interacting Protein 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include translation repressor activity, mRNA regulatory element binding. An important paralog of this gene is PAIP2.
UniProtKB/Swiss-Prot for PAIP2B Gene
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.