Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP... See more...

Aliases for PAIP2B Gene

Aliases for PAIP2B Gene

  • Poly(A) Binding Protein Interacting Protein 2B 2 3 5
  • Polyadenylate-Binding Protein-Interacting Protein 2B 3 4
  • PABP-Interacting Protein 2B 3 4
  • PAIP-2B 3 4
  • Poly(A)-Binding Protein-Interacting Protein 2B 4
  • KIAA1155 4

External Ids for PAIP2B Gene

Previous GeneCards Identifiers for PAIP2B Gene

  • GC02M071264
  • GC02M071409
  • GC02M071146

Summaries for PAIP2B Gene

Entrez Gene Summary for PAIP2B Gene

  • Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PAIP2B Gene

PAIP2B (Poly(A) Binding Protein Interacting Protein 2B) is a Protein Coding gene. Diseases associated with PAIP2B include Cone-Rod Dystrophy 17 and Retinitis Pigmentosa 63. Gene Ontology (GO) annotations related to this gene include translation repressor activity, mRNA regulatory element binding. An important paralog of this gene is PAIP2.

UniProtKB/Swiss-Prot Summary for PAIP2B Gene

  • Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Additional gene information for PAIP2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAIP2B Gene

Genomics for PAIP2B Gene

GeneHancer (GH) Regulatory Elements for PAIP2B Gene

Promoters and enhancers for PAIP2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAIP2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAIP2B

Top Transcription factor binding sites by QIAGEN in the PAIP2B gene promoter:
  • AML1a
  • CBF(2)
  • FOXO4
  • HNF-1
  • HNF-1A
  • MAZR
  • NF-Y
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PAIP2B Gene

Genomic Locations for PAIP2B Gene
chr2:71,182,738-71,227,114
(GRCh38/hg38)
Size:
44,377 bases
Orientation:
Minus strand
chr2:71,409,868-71,454,233
(GRCh37/hg19)
Size:
44,366 bases
Orientation:
Minus strand

Genomic View for PAIP2B Gene

Genes around PAIP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP2B Gene

Proteins for PAIP2B Gene

  • Protein details for PAIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULR5-PAI2B_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 2B
    Protein Accession:
    Q9ULR5

    Protein attributes for PAIP2B Gene

    Size:
    123 amino acids
    Molecular mass:
    14237 Da
    Quaternary structure:
    • Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).
    SequenceCaution:
    • Sequence=BAA86469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PAIP2B Gene

Post-translational modifications for PAIP2B Gene

Other Protein References for PAIP2B Gene

No data available for DME Specific Peptides for PAIP2B Gene

Domains & Families for PAIP2B Gene

Gene Families for PAIP2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAIP2B Gene

Blocks:
  • Ataxin-2, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAIP2B Gene

GenScript: Design optimal peptide antigens:
  • Polyadenylate-binding protein-interacting protein 2B (PAI2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULR5

UniProtKB/Swiss-Prot:

PAI2B_HUMAN :
  • Belongs to the PAIP2 family.
Family:
  • Belongs to the PAIP2 family.
genes like me logo Genes that share domains with PAIP2B: view

Function for PAIP2B Gene

Molecular function for PAIP2B Gene

UniProtKB/Swiss-Prot Function:
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Phenotypes From GWAS Catalog for PAIP2B Gene

Gene Ontology (GO) - Molecular Function for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IDA 16804161
GO:0005515 protein binding IPI 16804161
genes like me logo Genes that share ontologies with PAIP2B: view
genes like me logo Genes that share phenotypes with PAIP2B: view

Animal Models for PAIP2B Gene

MGI Knock Outs for PAIP2B:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAIP2B Gene

Localization for PAIP2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAIP2B gene
Compartment Confidence
nucleus 3
mitochondrion 2
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 16804161
genes like me logo Genes that share ontologies with PAIP2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PAIP2B Gene

Pathways & Interactions for PAIP2B Gene

PathCards logo

SuperPathways for PAIP2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0045947 negative regulation of translational initiation IDA 16804161
genes like me logo Genes that share ontologies with PAIP2B: view

No data available for Pathways by source and SIGNOR curated interactions for PAIP2B Gene

Drugs & Compounds for PAIP2B Gene

No Compound Related Data Available

Transcripts for PAIP2B Gene

mRNA/cDNA for PAIP2B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2B Gene

No ASD Table

Relevant External Links for PAIP2B Gene

GeneLoc Exon Structure for
PAIP2B

Expression for PAIP2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAIP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAIP2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.6), Brain - Substantia nigra (x5.2), Brain - Amygdala (x4.6), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for PAIP2B Gene

This gene is overexpressed in Skin (57.1) and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAIP2B Gene



Protein tissue co-expression partners for PAIP2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAIP2B

SOURCE GeneReport for Unigene cluster for PAIP2B Gene:

Hs.416735

mRNA Expression by UniProt/SwissProt for PAIP2B Gene:

Q9ULR5-PAI2B_HUMAN
Tissue specificity: Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.

Evidence on tissue expression from TISSUES for PAIP2B Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PAIP2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAIP2B Gene

Orthologs for PAIP2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAIP2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAIP2B 31 30
  • 99.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PAIP2B 31 30
  • 93.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475800 30
  • 91.87 (n)
PAIP2B 31
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paip2b 17 31 30
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Paip2b 30
  • 89.16 (n)
oppossum
(Monodelphis domestica)
Mammalia PAIP2B 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP2B 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paip2b 30
  • 78.59 (n)
zebrafish
(Danio rerio)
Actinopterygii paip2b 31 30
  • 69.95 (n)
OneToOne
Species where no ortholog for PAIP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP2B Gene

ENSEMBL:
Gene Tree for PAIP2B (if available)
TreeFam:
Gene Tree for PAIP2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAIP2B: view image

Paralogs for PAIP2B Gene

Paralogs for PAIP2B Gene

(1) SIMAP similar genes for PAIP2B Gene using alignment to 1 proteins:

  • PAI2B_HUMAN
genes like me logo Genes that share paralogs with PAIP2B: view

Variants for PAIP2B Gene

Additional dbSNP identifiers (rs#s) for PAIP2B Gene

Structural Variations from Database of Genomic Variants (DGV) for PAIP2B Gene

Variant ID Type Subtype PubMed ID
esv2720185 CNV deletion 23290073
nsv1127733 CNV deletion 24896259
nsv508148 CNV deletion 20534489
nsv834256 CNV gain 17160897
nsv963618 CNV duplication 23825009

Variation tolerance for PAIP2B Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAIP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAIP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAIP2B Gene

Disorders for PAIP2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAIP2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 17
  • cord17
retinitis pigmentosa 63
  • rp63
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PAIP2B

genes like me logo Genes that share disorders with PAIP2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAIP2B Gene

Publications for PAIP2B Gene

  1. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PMID: 16804161) Berlanga JJ … Sonenberg N (RNA (New York, N.Y.) 2006) 2 3 4 54
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. (PMID: 28470677) Tang H … Li D (International journal of cancer 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for PAIP2B Gene

Sources for PAIP2B Gene