Aliases for PAIP2 Gene

Aliases for PAIP2 Gene

  • Poly(A) Binding Protein Interacting Protein 2 2 3 5
  • Polyadenylate-Binding Protein-Interacting Protein 2 3 4
  • PABP-Interacting Protein 2 3 4
  • PAIP-2 3 4
  • PAIP2A 3 4
  • Poly(A)-Binding Protein-Interacting Protein 2 4
  • PolyA-Binding Protein-Interacting Protein 2 3
  • PABC1-Interacting Protein 2 3

External Ids for PAIP2 Gene

Previous GeneCards Identifiers for PAIP2 Gene

  • GC05P138553
  • GC05P138709
  • GC05P138754
  • GC05P138755
  • GC05P138706
  • GC05P133867
  • GC05P138677

Summaries for PAIP2 Gene

GeneCards Summary for PAIP2 Gene

PAIP2 (Poly(A) Binding Protein Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Translational Control and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include mRNA binding and translation repressor activity. An important paralog of this gene is PAIP2B.

UniProtKB/Swiss-Prot Summary for PAIP2 Gene

  • Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Gene Wiki entry for PAIP2 Gene

Additional gene information for PAIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAIP2 Gene

Genomics for PAIP2 Gene

GeneHancer (GH) Regulatory Elements for PAIP2 Gene

Promoters and enhancers for PAIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J139341 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.1 1114 4.2 EP300 ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 MYC USF1 POLR2G NONHSAG041694.2 PAIP2 KDM3B PURA RPL7P19 SLC23A1 MZB1 PROB1 MATR3 SNORA74A
GH05J139381 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +48.1 48131 15.5 ZBTB40 ZNF217 CTCF SIN3A TCF12 POLR2G USF1 SP1 PHF8 EP300 SLC23A1 MZB1 lnc-PROB1-1 DNAJC18 PURA PAIP2 SIL1 MATR3 RPL7P19 PROB1
GH05J139297 Promoter/Enhancer 0.9 Ensembl dbSUPER 11.9 -43.9 -43886 0.2 OSR2 ZBTB17 TCF7L2 PBX2 ZBTB1 IKZF3 ZNF843 PRDM6 FEZF1 MEIS2 MATR3 SNORA74D PAIP2 SLC23A1 RF00001-264 RNA5SP195 SIL1 lnc-SIL1-3 ENSG00000280987 SNHG4
GH05J139422 Enhancer 1 Ensembl ENCODE 10.7 +80.9 80930 0.6 CTCF REST RFX1 MYC RAD21 TRIM22 ATF2 SMC3 ZSCAN9 DEK DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 lnc-SPATA24-1
GH05J139310 Enhancer 0.8 ENCODE dbSUPER 12.3 -30.7 -30676 0.8 ZBTB17 FOS PRDM6 ZNF18 ZNF2 ZFP69B KLF1 JUND ZNF366 ZNF660 lnc-PAIP2-2 MATR3 PAIP2 SNORA74A SLC23A1 HSPA9 SNORD63B SNORD63 RF00017-4937 ENSG00000280987
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAIP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAIP2

Top Transcription factor binding sites by QIAGEN in the PAIP2 gene promoter:
  • FOXL1
  • FOXO1
  • FOXO1a
  • oct-B2
  • oct-B3

Genomic Locations for PAIP2 Gene

Genomic Locations for PAIP2 Gene
chr5:139,341,587-139,369,720
(GRCh38/hg38)
Size:
28,134 bases
Orientation:
Plus strand
chr5:138,677,276-138,705,409
(GRCh37/hg19)
Size:
28,134 bases
Orientation:
Plus strand

Genomic View for PAIP2 Gene

Genes around PAIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP2 Gene

Proteins for PAIP2 Gene

  • Protein details for PAIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ3-PAIP2_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 2
    Protein Accession:
    Q9BPZ3
    Secondary Accessions:
    • B2RBI1
    • D3DQC6
    • Q49A06
    • Q9H0Y5
    • Q9P0Q8

    Protein attributes for PAIP2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14984 Da
    Quaternary structure:
    • Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.

    Three dimensional structures from OCA and Proteopedia for PAIP2 Gene

neXtProt entry for PAIP2 Gene

Post-translational modifications for PAIP2 Gene

  • Ubiquitinated, leading to its degradation by the proteasome.
  • Ubiquitination at Lys116
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAIP2 Gene

Domains & Families for PAIP2 Gene

Gene Families for PAIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAIP2 Gene

Blocks:
  • Ataxin-2, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAIP2 Gene

GenScript: Design optimal peptide antigens:
  • Polyadenylate-binding protein-interacting protein 2 (PAIP2_HUMAN)
  • PAIP2 protein (Q49AE6_HUMAN)
  • PAIP2 protein (Q6FID7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BPZ3

UniProtKB/Swiss-Prot:

PAIP2_HUMAN :
  • Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
  • Belongs to the PAIP2 family.
Domain:
  • Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
Family:
  • Belongs to the PAIP2 family.
genes like me logo Genes that share domains with PAIP2: view

Function for PAIP2 Gene

Molecular function for PAIP2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Phenotypes From GWAS Catalog for PAIP2 Gene

Gene Ontology (GO) - Molecular Function for PAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IEA --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 11172725
GO:0030371 translation repressor activity IDA 11172725
genes like me logo Genes that share ontologies with PAIP2: view
genes like me logo Genes that share phenotypes with PAIP2: view

Animal Models for PAIP2 Gene

MGI Knock Outs for PAIP2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAIP2 Gene

Localization for PAIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAIP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAIP2 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 11172725
genes like me logo Genes that share ontologies with PAIP2: view

Pathways & Interactions for PAIP2 Gene

PathCards logo

SuperPathways for PAIP2 Gene

SuperPathway Contained pathways
1 Translational Control
2 TGF-Beta Pathway
.43
genes like me logo Genes that share pathways with PAIP2: view

Pathways by source for PAIP2 Gene

1 Qiagen pathway for PAIP2 Gene
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for PAIP2 Gene

Gene Ontology (GO) - Biological Process for PAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007283 spermatogenesis IEA --
GO:0007613 memory IEA --
GO:0045947 negative regulation of translational initiation IDA 11172725
GO:1900271 regulation of long-term synaptic potentiation IEA --
genes like me logo Genes that share ontologies with PAIP2: view

No data available for SIGNOR curated interactions for PAIP2 Gene

Drugs & Compounds for PAIP2 Gene

(2) Additional Compounds for PAIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAIP2: view

Transcripts for PAIP2 Gene

mRNA/cDNA for PAIP2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for PAIP2 Gene

GeneLoc Exon Structure for
PAIP2

Expression for PAIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAIP2 Gene



Protein tissue co-expression partners for PAIP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAIP2

SOURCE GeneReport for Unigene cluster for PAIP2 Gene:

Hs.396644

mRNA Expression by UniProt/SwissProt for PAIP2 Gene:

Q9BPZ3-PAIP2_HUMAN
Tissue specificity: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.

Evidence on tissue expression from TISSUES for PAIP2 Gene

  • Nervous system(4.9)
  • Eye(4.5)
  • Blood(4.1)
  • Lung(3)
  • Pancreas(3)
  • Skin(2.7)
  • Adrenal gland(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with PAIP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAIP2 Gene

Orthologs for PAIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAIP2 31 30
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAIP2 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Paip2 17 31 30
  • 98.12 (n)
dog
(Canis familiaris)
Mammalia PAIP2 31 30
  • 97.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PAIP2 31 30
  • 97.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paip2 30
  • 97.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAIP2 31
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAIP2 31 30
  • 90.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAIP2 31
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3840 30
Species where no ortholog for PAIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAIP2 Gene

ENSEMBL:
Gene Tree for PAIP2 (if available)
TreeFam:
Gene Tree for PAIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAIP2: view image

Paralogs for PAIP2 Gene

Paralogs for PAIP2 Gene

(1) SIMAP similar genes for PAIP2 Gene using alignment to 5 proteins:

  • PAIP2_HUMAN
  • D6R9Y1_HUMAN
  • D6RA77_HUMAN
  • Q49AE6_HUMAN
  • Q6FID7_HUMAN
genes like me logo Genes that share paralogs with PAIP2: view

Variants for PAIP2 Gene

Additional dbSNP identifiers (rs#s) for PAIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PAIP2 Gene

Variant ID Type Subtype PubMed ID
esv3606938 CNV loss 21293372
nsv1137029 CNV deletion 24896259
nsv1140574 CNV deletion 24896259

Variation tolerance for PAIP2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAIP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAIP2 Gene

Disorders for PAIP2 Gene

Additional Disease Information for PAIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PAIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP2 Gene

Publications for PAIP2 Gene

  1. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PMID: 11172725) Khaleghpour K … Sonenberg N (Molecular cell 2001) 2 3 4 23 54
  2. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. (PMID: 16804161) Berlanga JJ … Sonenberg N (RNA (New York, N.Y.) 2006) 2 3 4 54
  3. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. (PMID: 11438674) Khaleghpour K … Sonenberg N (Molecular and cellular biology 2001) 3 4 23 54
  4. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert TA … Walter MJ (PloS one 2009) 3 41 54
  5. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. (PMID: 16601676) Yoshida M … Sonenberg N (The EMBO journal 2006) 3 23 54

Products for PAIP2 Gene

Sources for PAIP2 Gene