Aliases for PAIP2 Gene
External Ids for PAIP2 Gene
Previous GeneCards Identifiers for PAIP2 Gene
GeneCards Summary for PAIP2 Gene
PAIP2 (Poly(A) Binding Protein Interacting Protein 2) is a Protein Coding gene. Diseases associated with PAIP2 include Myoclonic Epilepsy, Juvenile 3. Among its related pathways are TGF-Beta Pathway and Translational Control. Gene Ontology (GO) annotations related to this gene include mRNA binding and translation repressor activity. An important paralog of this gene is PAIP2B.
UniProtKB/Swiss-Prot Summary for PAIP2 Gene
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.