This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. The encoded protein may protect cells from programmed cell death. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jan 2015] See more...

Aliases for PAGE5 Gene

Aliases for PAGE5 Gene

  • PAGE Family Member 5 2 3 5
  • CT16.1 2 3 4
  • PAGE-5 2 3 4
  • P Antigen Family, Member 5 (Prostate Associated) 2 3
  • Cancer/Testis Antigen Family 16, Member 1 2 3
  • Cancer/Testis Antigen Family 16, Member 2 2 3
  • Prostate-Associated Gene 5 Protein 3 4
  • G Antigen Family E Member 1 3 4
  • Cancer/Testis Antigen 16.1 3 4
  • P Antigen Family Member 5 3 4
  • CT16.2 2 3
  • GAGEE1 3 4
  • PAGE5 5
  • CT16 3

External Ids for PAGE5 Gene

Previous GeneCards Identifiers for PAGE5 Gene

  • GC0XP055130
  • GC0XP052295

Summaries for PAGE5 Gene

Entrez Gene Summary for PAGE5 Gene

  • This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. The encoded protein may protect cells from programmed cell death. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jan 2015]

GeneCards Summary for PAGE5 Gene

PAGE5 (PAGE Family Member 5) is a Protein Coding gene. An important paralog of this gene is PAGE2B.

Additional gene information for PAGE5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAGE5 Gene

Genomics for PAGE5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PAGE5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ055220 Promoter 0.8 EPDnew 600.7 0.0 -16 0.1 NRF1 MGA ZNF766 USF2 POLR2A ZBTB2 MNT TBP SMAD5 SUPT5H PAGE5 MTRNR2L10 RF00177-017
GH0XJ055265 Promoter 0.3 EPDnew 0.3 +44.4 44356 0.1 PAGE3 piR-33056-007 PAGE5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAGE5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAGE5

Genomic Locations for PAGE5 Gene

Genomic Locations for PAGE5 Gene
chrX:55,220,346-55,224,108
(GRCh38/hg38)
Size:
3,763 bases
Orientation:
Plus strand
chrX:55,246,788-55,250,541
(GRCh37/hg19)
Size:
3,754 bases
Orientation:
Plus strand

Genomic View for PAGE5 Gene

Genes around PAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE5 Gene

Proteins for PAGE5 Gene

  • Protein details for PAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GU1-PAGE5_HUMAN
    Recommended name:
    P antigen family member 5
    Protein Accession:
    Q96GU1
    Secondary Accessions:
    • Q2NL97
    • Q5JUL0
    • Q8WWL9

    Protein attributes for PAGE5 Gene

    Size:
    130 amino acids
    Molecular mass:
    14046 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PAGE5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAGE5 Gene

Post-translational modifications for PAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE5 Gene

No data available for DME Specific Peptides for PAGE5 Gene

Domains & Families for PAGE5 Gene

Gene Families for PAGE5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAGE5 Gene

InterPro:
Blocks:
  • GAGE
ProtoNet:

Suggested Antigen Peptide Sequences for PAGE5 Gene

GenScript: Design optimal peptide antigens:
  • Prostate-associated gene 5 protein (GGEE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GU1

UniProtKB/Swiss-Prot:

PAGE5_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE5: view

Function for PAGE5 Gene

Phenotypes From GWAS Catalog for PAGE5 Gene

Gene Ontology (GO) - Molecular Function for PAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with PAGE5: view
genes like me logo Genes that share phenotypes with PAGE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAGE5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE5 Gene

Localization for PAGE5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAGE5 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE5 Gene

Pathways & Interactions for PAGE5 Gene

PathCards logo

SuperPathways for PAGE5 Gene

No Data Available

Interacting Proteins for PAGE5 Gene

Gene Ontology (GO) - Biological Process for PAGE5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAGE5 Gene

Drugs & Compounds for PAGE5 Gene

No Compound Related Data Available

Transcripts for PAGE5 Gene

mRNA/cDNA for PAGE5 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAGE5

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE5 Gene

No ASD Table

Relevant External Links for PAGE5 Gene

GeneLoc Exon Structure for
PAGE5

Expression for PAGE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAGE5 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE5 Gene

This gene is overexpressed in Testis (x47.4).

Protein differential expression in normal tissues from HIPED for PAGE5 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAGE5 Gene



Protein tissue co-expression partners for PAGE5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAGE5

SOURCE GeneReport for Unigene cluster for PAGE5 Gene:

Hs.668491

Evidence on tissue expression from TISSUES for PAGE5 Gene

  • Nervous system(2.2)
  • Skin(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PAGE5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAGE5 Gene

Orthologs for PAGE5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PAGE5 30 31
  • 99.23 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 44 (a)
ManyToMany
Species where no ortholog for PAGE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PAGE5 Gene

ENSEMBL:
Gene Tree for PAGE5 (if available)
TreeFam:
Gene Tree for PAGE5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAGE5: view image

Paralogs for PAGE5 Gene

(7) SIMAP similar genes for PAGE5 Gene using alignment to 2 proteins:

  • PAGE5_HUMAN
  • Q5JUL1_HUMAN

Pseudogenes.org Pseudogenes for PAGE5 Gene

genes like me logo Genes that share paralogs with PAGE5: view

Variants for PAGE5 Gene

Additional dbSNP identifiers (rs#s) for PAGE5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PAGE5 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for PAGE5 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAGE5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAGE5 Gene

Disorders for PAGE5 Gene

No disorders were found for PAGE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAGE5 Gene

Publications for PAGE5 Gene

  1. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Identification of cancer/testis genes by database mining and mRNA expression analysis. (PMID: 11920606) Scanlan MJ … Old LJ (International journal of cancer 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PAGE5 Gene

  • Signalway Proteins for PAGE5

Sources for PAGE5 Gene