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Aliases for PAGE1 Gene

Aliases for PAGE1 Gene

  • PAGE Family Member 1 2 3 5
  • P Antigen Family, Member 1 (Prostate Associated) 2 3
  • G Antigen, Family B, 1 (Prostate Associated) 2 3
  • Prostate-Associated Gene 1 Protein 3 4
  • G Antigen Family B Member 1 3 4
  • G Antigen 9 3 4
  • GAGEB1 3 4
  • GAGE-9 3 4
  • PAGE-1 3 4
  • AL5 3 4
  • Prostate Associated Gene 1 3
  • P Antigen Family Member 1 3
  • CT16.3 3
  • GAGE9 4

External Ids for PAGE1 Gene

Previous HGNC Symbols for PAGE1 Gene

  • GAGEB1

Previous GeneCards Identifiers for PAGE1 Gene

  • GC0XM049156
  • GC0XM049339
  • GC0XM049452
  • GC0XM046922

Summaries for PAGE1 Gene

Entrez Gene Summary for PAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAGE1 Gene

PAGE1 (PAGE Family Member 1) is a Protein Coding gene. An important paralog of this gene is GAGE10.

Additional gene information for PAGE1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAGE1 Gene

Genomics for PAGE1 Gene

GeneHancer (GH) Regulatory Elements for PAGE1 Gene

Promoters and enhancers for PAGE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ049695 Promoter 0.7 EPDnew 650.7 +0.0 15 0.1 L3MBTL2 NRF1 MGA PAGE1 SALL1P1
GH0XJ048910 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 14.6 +783.8 783844 4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 FOS SLC35A2 ENSG00000204620 GAGE12J SSXP9 GAGE12G SSX9 GAGE1 GAGE2A PAGE1 ENSG00000270747
GH0XJ049812 Enhancer 0.7 ENCODE 0.1 -116.2 -116236 0.2 SOX13 FOXA2 SAP130 RARA TEAD3 LCORL RERE NR2F6 CREM TCF7L2 PAGE4 PAGE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAGE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAGE1 gene promoter:
  • C/EBPalpha
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • CHOP-10
  • HFH-1
  • STAT3
  • CP2

Genomic Locations for PAGE1 Gene

Genomic Locations for PAGE1 Gene
8,568 bases
Minus strand
8,544 bases
Minus strand

Genomic View for PAGE1 Gene

Genes around PAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAGE1 Gene

Proteins for PAGE1 Gene

  • Protein details for PAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P antigen family member 1
    Protein Accession:
    Secondary Accessions:
    • Q6FGM3
    • Q9BSS7

    Protein attributes for PAGE1 Gene

    146 amino acids
    Molecular mass:
    16150 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for PAGE1 Gene

Post-translational modifications for PAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAGE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAGE1 Gene

Domains & Families for PAGE1 Gene

Gene Families for PAGE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAGE1 Gene


Suggested Antigen Peptide Sequences for PAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with PAGE1: view

Function for PAGE1 Gene

Gene Ontology (GO) - Molecular Function for PAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PAGE1: view
genes like me logo Genes that share phenotypes with PAGE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAGE1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAGE1 Gene

Localization for PAGE1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAGE1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAGE1 Gene

Pathways & Interactions for PAGE1 Gene

SuperPathways for PAGE1 Gene

No Data Available

Interacting Proteins for PAGE1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: O75459-PAGE1_HUMAN ENSP00000365320 for PAGE1 Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for PAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9651357
genes like me logo Genes that share ontologies with PAGE1: view

No data available for Pathways by source and SIGNOR curated interactions for PAGE1 Gene

Drugs & Compounds for PAGE1 Gene

No Compound Related Data Available

Transcripts for PAGE1 Gene

mRNA/cDNA for PAGE1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAGE1 Gene

P antigen family, member 1 (prostate associated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAGE1

Alternative Splicing Database (ASD) splice patterns (SP) for PAGE1 Gene

No ASD Table

Relevant External Links for PAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PAGE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for PAGE1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for PAGE1 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAGE1 Gene

Protein tissue co-expression partners for PAGE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAGE1 Gene:


SOURCE GeneReport for Unigene cluster for PAGE1 Gene:


mRNA Expression by UniProt/SwissProt for PAGE1 Gene:

Tissue specificity: Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta.

Evidence on tissue expression from TISSUES for PAGE1 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with PAGE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAGE1 Gene

Orthologs for PAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PAGE1 34 33
  • 99.32 (n)
Species where no ortholog for PAGE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PAGE1 Gene

Gene Tree for PAGE1 (if available)
Gene Tree for PAGE1 (if available)
Evolutionary constrained regions (ECRs) for PAGE1: view image

Paralogs for PAGE1 Gene

(7) SIMAP similar genes for PAGE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PAGE1: view

Variants for PAGE1 Gene

Sequence variations from dbSNP and Humsavar for PAGE1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000866467 -- 49,696,546(-) T/A upstream_transcript_variant
rs1000982033 -- 49,696,161(-) A/T upstream_transcript_variant
rs1001605307 -- 49,690,314(-) G/A intron_variant
rs1002871356 -- 49,692,584(-) G/T intron_variant
rs1004029681 -- 49,687,089(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PAGE1 Gene

Variant ID Type Subtype PubMed ID
esv1069714 CNV insertion 17803354
nsv6901 CNV insertion 18451855

Variation tolerance for PAGE1 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAGE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAGE1 Gene

Disorders for PAGE1 Gene

Additional Disease Information for PAGE1

No disorders were found for PAGE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAGE1 Gene

Publications for PAGE1 Gene

  1. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen ME … Sikes RA (The Journal of biological chemistry 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (PMID: 9724777) Brinkmann U … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for PAGE1 Gene

Sources for PAGE1 Gene

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