Aliases for PAFAH2 Gene
External Ids for PAFAH2 Gene
Previous GeneCards Identifiers for PAFAH2 Gene
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAFAH2 Gene
PAFAH2 (Platelet Activating Factor Acetylhydrolase 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Metabolism. Gene Ontology (GO) annotations related to this gene include phospholipid binding and 1-alkyl-2-acetylglycerophosphocholine esterase activity. An important paralog of this gene is PLA2G7.
UniProtKB/Swiss-Prot for PAFAH2 Gene
Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.