Aliases for PADI4 Gene
External Ids for PADI4 Gene
Previous HGNC Symbols for PADI4 Gene
Previous GeneCards Identifiers for PADI4 Gene
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
GeneCards Summary for PADI4 Gene
PADI4 (Peptidyl Arginine Deiminase 4) is a Protein Coding gene. Diseases associated with PADI4 include Rheumatoid Arthritis and Arthritis. Among its related pathways are protein citrullination and Chromatin organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and arginine deiminase activity. An important paralog of this gene is PADI1.
UniProtKB/Swiss-Prot Summary for PADI4 Gene
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.