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Aliases for PADI2 Gene

Aliases for PADI2 Gene

  • Peptidyl Arginine Deiminase 2 2 3 5
  • Peptidyl Arginine Deiminase, Type II 2 3
  • Protein-Arginine Deiminase Type II 3 4
  • PAD-H19 3 4
  • PAD2 3 4
  • PDI2 3 4
  • Protein-Arginine Deiminase Type-2 3
  • Peptidylarginine Deiminase II 4
  • EC 4
  • KIAA0994 4

External Ids for PADI2 Gene

Previous GeneCards Identifiers for PADI2 Gene

  • GC01M017130
  • GC01M016434
  • GC01M016775
  • GC01M016776
  • GC01M017138
  • GC01M017265
  • GC01M017393
  • GC01M015637

Summaries for PADI2 Gene

Entrez Gene Summary for PADI2 Gene

  • This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PADI2 Gene

PADI2 (Peptidyl Arginine Deiminase 2) is a Protein Coding gene. Diseases associated with PADI2 include Multiple Sclerosis and Alzheimer Disease. Among its related pathways are Innate Immune System and Chromatin organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI1.

UniProtKB/Swiss-Prot for PADI2 Gene

  • Catalyzes the deimination of arginine residues of proteins.

Gene Wiki entry for PADI2 Gene

Additional gene information for PADI2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PADI2 Gene

Genomics for PADI2 Gene

GeneHancer (GH) Regulatory Elements for PADI2 Gene

Promoters and enhancers for PADI2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J017119 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.1 -55 0.2 CTCF PKNOX1 RB1 DDX20 BACH1 EBF1 KLF14 POLR2A NFYB SCRT2 PADI2 PIR46847 GC01M017107 GC01M017106
GH01J017120 Enhancer 0.9 ENCODE dbSUPER 650.7 -0.9 -868 0.2 CTCF HDGF RB1 ZNF223 KLF17 EBF1 ZIC2 ZFHX2 GLIS2 POLR2A PADI2 PIR46847 GC01M017106 GC01M017107
GH01J017117 Enhancer 0.7 dbSUPER 650.7 +1.1 1078 1.9 CTCF KLF1 PKNOX1 RB1 BACH1 EBF1 KLF14 POLR2A ZBTB48 SCRT2 PADI2 SDHB GC01M017106 GC01M017107
GH01J017096 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 104.9 +20.8 20848 3.4 SMARCA5 ZNF768 PKNOX1 ZNF687 PHF21A KLF17 CEBPB ZMYM3 EBF1 MEF2B PADI2 PADI4 CROCCP2 SDHB
GH01J017100 Enhancer 0.6 dbSUPER 90.5 +17.1 17100 3.3 BCOR ZNF768 CBX1 HDAC2 ZFP36 ZMYM3 KDM1A ZKSCAN1 PADI2 SDHB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PADI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PADI2 gene promoter:
  • Max1
  • c-Myc
  • Sp1
  • Arnt
  • AhR
  • E47
  • RREB-1
  • NF-1/L
  • NF-1

Genomic Locations for PADI2 Gene

Genomic Locations for PADI2 Gene
52,693 bases
Minus strand
52,693 bases
Minus strand

Genomic View for PADI2 Gene

Genes around PADI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PADI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PADI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PADI2 Gene

Proteins for PADI2 Gene

  • Protein details for PADI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-arginine deiminase type-2
    Protein Accession:
    Secondary Accessions:
    • Q96DA7
    • Q9UPN2

    Protein attributes for PADI2 Gene

    665 amino acids
    Molecular mass:
    75564 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=BAA76838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PADI2 Gene

    Alternative splice isoforms for PADI2 Gene


neXtProt entry for PADI2 Gene

Post-translational modifications for PADI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PADI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for PADI2
  • Santa Cruz Biotechnology (SCBT) Antibodies for PADI2

No data available for DME Specific Peptides for PADI2 Gene

Domains & Families for PADI2 Gene

Gene Families for PADI2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PADI2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein arginine deiminase family.
  • Belongs to the protein arginine deiminase family.
genes like me logo Genes that share domains with PADI2: view

Function for PADI2 Gene

Molecular function for PADI2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the deimination of arginine residues of proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).

Enzyme Numbers (IUBMB) for PADI2 Gene

Phenotypes From GWAS Catalog for PADI2 Gene

Gene Ontology (GO) - Molecular Function for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004668 protein-arginine deiminase activity IDA 12392711
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0030331 estrogen receptor binding IPI 22853951
genes like me logo Genes that share ontologies with PADI2: view
genes like me logo Genes that share phenotypes with PADI2: view

Animal Models for PADI2 Gene

MGI Knock Outs for PADI2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PADI2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PADI2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PADI2 Gene

Localization for PADI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PADI2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PADI2 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
lysosome 4
mitochondrion 3
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 12392711
GO:0005829 cytosol TAS --
GO:0035327 transcriptionally active chromatin IDA 22853951
genes like me logo Genes that share ontologies with PADI2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PADI2 Gene

Pathways & Interactions for PADI2 Gene

genes like me logo Genes that share pathways with PADI2: view

Pathways by source for PADI2 Gene

Interacting Proteins for PADI2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9Y2J8-PADI2_HUMAN ENSP00000364635 for PADI2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PADI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0010848 regulation of chromatin disassembly IDA 22853951
GO:0018101 protein citrullination IDA 12392711
GO:0021762 substantia nigra development HEP 22926577
GO:0030520 intracellular estrogen receptor signaling pathway IMP 22853951
genes like me logo Genes that share ontologies with PADI2: view

No data available for SIGNOR curated interactions for PADI2 Gene

Drugs & Compounds for PADI2 Gene

(5) Drugs for PADI2 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citrulline Approved, Investigational Nutra Full agonist, Agonist, Target 0
Ammonia Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
ADI-PEG 20 Pharma inhibitor 0
genes like me logo Genes that share compounds with PADI2: view

Transcripts for PADI2 Gene

mRNA/cDNA for PADI2 Gene

Unigene Clusters for PADI2 Gene

Peptidyl arginine deiminase, type II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PADI2

Alternative Splicing Database (ASD) splice patterns (SP) for PADI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for PADI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PADI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PADI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PADI2 Gene

This gene is overexpressed in Muscle - Skeletal (x11.1), Whole Blood (x9.1), and Brain - Spinal cord (cervical c-1) (x7.6).

Protein differential expression in normal tissues from HIPED for PADI2 Gene

This gene is overexpressed in Spinal cord (35.2), Retina (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PADI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PADI2 Gene:


SOURCE GeneReport for Unigene cluster for PADI2 Gene:


Evidence on tissue expression from TISSUES for PADI2 Gene

  • Nervous system(4.7)
  • Skin(4.2)
  • Pancreas(4.1)
  • Muscle(3.1)
  • Blood(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PADI2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PADI2 Gene

Orthologs for PADI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PADI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PADI2 34 33
  • 99.45 (n)
(Bos Taurus)
Mammalia PADI2 34
  • 92 (a)
(Canis familiaris)
Mammalia PADI2 34 33
  • 91.48 (n)
(Rattus norvegicus)
Mammalia Padi2 33
  • 88.37 (n)
(Mus musculus)
Mammalia Padi2 16 34 33
  • 88.02 (n)
(Monodelphis domestica)
Mammalia PADI2 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PADI2 34
  • 71 (a)
(Gallus gallus)
Aves PADI2 34 33
  • 70.44 (n)
(Anolis carolinensis)
Reptilia PADI2 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia padi2 33
  • 65.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia padi2-prov 33
(Danio rerio)
Actinopterygii padi2 34 33
  • 59.95 (n)
sbcb968 33
Species where no ortholog for PADI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PADI2 Gene

Gene Tree for PADI2 (if available)
Gene Tree for PADI2 (if available)
Evolutionary constrained regions (ECRs) for PADI2: view image

Paralogs for PADI2 Gene

Paralogs for PADI2 Gene

(4) SIMAP similar genes for PADI2 Gene using alignment to 3 proteins:

  • Q96DA7_HUMAN
genes like me logo Genes that share paralogs with PADI2: view

Variants for PADI2 Gene

Sequence variations from dbSNP and Humsavar for PADI2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000042855 -- 17,097,534(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000146890 -- 17,086,644(-) A/G coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000192763 -- 17,081,891(-) T/A intron_variant
rs1000293448 -- 17,109,006(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000321427 -- 17,104,231(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PADI2 Gene

Variant ID Type Subtype PubMed ID
esv2422314 CNV duplication 17116639
esv2758925 CNV gain+loss 17122850
esv3305460 CNV mobile element insertion 20981092
esv3310333 CNV mobile element insertion 20981092
esv3585359 CNV gain 21293372
nsv1009931 CNV gain 25217958
nsv1076191 CNV deletion 25765185
nsv1133818 CNV deletion 24896259
nsv1137735 CNV deletion 24896259
nsv1145323 CNV deletion 24896259
nsv428421 CNV gain+loss 18775914
nsv460662 CNV loss 19166990
nsv545690 CNV gain 21841781
nsv545691 CNV loss 21841781
nsv834280 CNV loss 17160897

Variation tolerance for PADI2 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PADI2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PADI2 Gene

Disorders for PADI2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PADI2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple sclerosis
  • multiple sclerosis, susceptibility to
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search PADI2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PADI2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PADI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PADI2 Gene

Publications for PADI2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. A two-stage case-control association study of PADI2 with schizophrenia. (PMID: 19478818) Watanabe Y … Someya T (Journal of human genetics 2009) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Comparison of enzymatic properties between hPADI2 and hPADI4. (PMID: 15629448) Nakayama-Hamada M … Yamamoto K (Biochemical and biophysical research communications 2005) 3 22 58
  5. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. (PMID: 15854045) Dong S … Takahara H (The Journal of investigative dermatology 2005) 22 25 58

Products for PADI2 Gene

Sources for PADI2 Gene

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