This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] See more...

Aliases for PACSIN2 Gene

Aliases for PACSIN2 Gene

  • Protein Kinase C And Casein Kinase Substrate In Neurons 2 2 3 5
  • Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 3 4
  • Syndapin-II 3 4
  • Syndapin-2 3 4
  • Cytoplasmic Phosphoprotein PACSIN2 3
  • Syndapin II 2
  • Syndapin2 3
  • SDPII 3
  • SdpII 4

External Ids for PACSIN2 Gene

Previous GeneCards Identifiers for PACSIN2 Gene

  • GC22M039868
  • GC22M041496
  • GC22M041590
  • GC22M043243
  • GC22M026224

Summaries for PACSIN2 Gene

Entrez Gene Summary for PACSIN2 Gene

  • This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PACSIN2 Gene

PACSIN2 (Protein Kinase C And Casein Kinase Substrate In Neurons 2) is a Protein Coding gene. Diseases associated with PACSIN2 include Thiopurines, Poor Metabolism Of, 1 and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is PACSIN1.

UniProtKB/Swiss-Prot Summary for PACSIN2 Gene

  • Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
  • (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077).

Gene Wiki entry for PACSIN2 Gene

Additional gene information for PACSIN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PACSIN2 Gene

Genomics for PACSIN2 Gene

GeneHancer (GH) Regulatory Elements for PACSIN2 Gene

Promoters and enhancers for PACSIN2 Gene