Aliases for PACSIN1 Gene
External Ids for PACSIN1 Gene
Previous GeneCards Identifiers for PACSIN1 Gene
GeneCards Summary for PACSIN1 Gene
PACSIN1 (Protein Kinase C And Casein Kinase Substrate In Neurons 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include phospholipid binding and cytoskeletal protein binding. An important paralog of this gene is PACSIN2.
UniProtKB/Swiss-Prot for PACSIN1 Gene
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.