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Aliases for PACS1 Gene

Aliases for PACS1 Gene

  • Phosphofurin Acidic Cluster Sorting Protein 1 2 3 3 5
  • PACS-1 3 4
  • Cytosolic Sorting Protein PACS-1 3
  • KIAA1175 4
  • MRD17 3
  • SHMS 3

External Ids for PACS1 Gene

Previous GeneCards Identifiers for PACS1 Gene

  • GC11P067519
  • GC11P065613
  • GC11P065595
  • GC11P065837
  • GC11P062163

Summaries for PACS1 Gene

Entrez Gene Summary for PACS1 Gene

  • This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]

GeneCards Summary for PACS1 Gene

PACS1 (Phosphofurin Acidic Cluster Sorting Protein 1) is a Protein Coding gene. Diseases associated with PACS1 include Schuurs-Hoeijmakers Syndrome and Pacs1-Related Syndrome. Among its related pathways are HIV Life Cycle and Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is PACS2.

UniProtKB/Swiss-Prot for PACS1 Gene

  • Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

Gene Wiki entry for PACS1 Gene

Additional gene information for PACS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PACS1 Gene

Genomics for PACS1 Gene

GeneHancer (GH) Regulatory Elements for PACS1 Gene

Promoters and enhancers for PACS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066067 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 660.5 -0.1 -86 4.9 HDGF ARID4B SIN3A DMAP1 ZNF48 POLR2B GLIS2 E2F8 ZNF143 RUNX3 ENSG00000255038 PACS1 LOC105369352 RBM14 ENSG00000254461 RBM4 SF3B2 ENSG00000258297 KAT5 BBS1
GH11J066111 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.2 +45.8 45812 10.3 HDGF HNRNPUL1 ATF1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A IRF4 ZNF48 ENSG00000255320 SF3B2 SART1 EIF1AD ENSG00000258297 ENSG00000255038 PACS1 KAT5 RBM14 CD248
GH11J066342 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.5 +278.2 278192 11.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 LOC102724064 B4GAT1 TRS-GCT3-1 RBM14 ENSG00000258297 LOC105369352 RBM4 EIF1AD RIN1 ENSG00000255320
GH11J066078 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +11.5 11457 7.5 HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZNF121 ZNF143 FOS RUNX3 ENSG00000255320 SF3B2 SIPA1 PACS1 CST6 BANF1 EIF1AD SART1 MAP3K11 AP5B1
GH11J066333 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10 +266.3 266326 6.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 SLC30A9 RIN1 ACTN3 ENSG00000254458 B4GAT1 RAB1B LOC105369351 LOC105369352 ENSG00000255320 PACS1 BANF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PACS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PACS1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • FOXO4
  • p300
  • RREB-1
  • RFX1
  • Evi-1
  • c-Myc
  • Max1

Genomic Locations for PACS1 Gene

Genomic Locations for PACS1 Gene
chr11:66,070,353-66,244,747
(GRCh38/hg38)
Size:
174,395 bases
Orientation:
Plus strand
chr11:65,837,824-66,012,218
(GRCh37/hg19)
Size:
174,395 bases
Orientation:
Plus strand

Genomic View for PACS1 Gene

Genes around PACS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACS1 Gene

Proteins for PACS1 Gene

  • Protein details for PACS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VY07-PACS1_HUMAN
    Recommended name:
    Phosphofurin acidic cluster sorting protein 1
    Protein Accession:
    Q6VY07
    Secondary Accessions:
    • Q6PJY6
    • Q6PKB6
    • Q7Z590
    • Q7Z5W4
    • Q8N8K6
    • Q96MW0
    • Q9NW92
    • Q9ULP5

    Protein attributes for PACS1 Gene

    Size:
    963 amino acids
    Molecular mass:
    104898 Da
    Quaternary structure:
    • Interacts with HIV-1 Nef (PubMed:10707087, PubMed:12526811, PubMed:18296443). Associates with AP-1 and AP-3 but not with AP-2 complexes (PubMed:11331585). Interacts with FURIN (By similarity). Forms a ternary complex with FURIN and AP-1 (PubMed:11331585). Interacts with NPHP1; the interaction is dependent of NPHP1 phosphorylation by CK2 (PubMed:16308564). Interacts with PKD2 (via acidic region) (PubMed:15692563). Interacts with Epstein_barr virus protein BBLF1 (PubMed:22740416).
    SequenceCaution:
    • Sequence=AAH09936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71164.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PACS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PACS1 Gene

Post-translational modifications for PACS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PACS1
  • Boster Bio Antibodies for PACS1
  • Santa Cruz Biotechnology (SCBT) Antibodies for PACS1

No data available for DME Specific Peptides for PACS1 Gene

Domains & Families for PACS1 Gene

Gene Families for PACS1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PACS1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6VY07

UniProtKB/Swiss-Prot:

PACS1_HUMAN :
  • Belongs to the PACS family.
Family:
  • Belongs to the PACS family.
genes like me logo Genes that share domains with PACS1: view

Function for PACS1 Gene

Molecular function for PACS1 Gene

UniProtKB/Swiss-Prot Function:
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

Phenotypes From GWAS Catalog for PACS1 Gene

Gene Ontology (GO) - Molecular Function for PACS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10707087
GO:0044325 ion channel binding IPI 15692563
genes like me logo Genes that share ontologies with PACS1: view
genes like me logo Genes that share phenotypes with PACS1: view

Human Phenotype Ontology for PACS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PACS1 Gene

Localization for PACS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PACS1 Gene

Golgi apparatus, trans-Golgi network. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000305 PubMed:11331585}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PACS1 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
nucleus 3
cytoskeleton 2
endosome 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PACS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030137 COPI-coated vesicle IEA --
genes like me logo Genes that share ontologies with PACS1: view

Pathways & Interactions for PACS1 Gene

genes like me logo Genes that share pathways with PACS1: view

Gene Ontology (GO) - Biological Process for PACS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0034067 protein localization to Golgi apparatus IEA --
GO:0050690 regulation of defense response to virus by virus TAS --
GO:0072659 protein localization to plasma membrane IMP 15692563
genes like me logo Genes that share ontologies with PACS1: view

No data available for SIGNOR curated interactions for PACS1 Gene

Drugs & Compounds for PACS1 Gene

(1) Drugs for PACS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mannose 6-phosphate Investigational Pharma 0
genes like me logo Genes that share compounds with PACS1: view

Transcripts for PACS1 Gene

mRNA/cDNA for PACS1 Gene

Unigene Clusters for PACS1 Gene

Phosphofurin acidic cluster sorting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PACS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - - -
SP2:
SP3:
SP4: -
SP5:
SP6:

ExUns: 22b · 22c · 22d ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for PACS1 Gene

GeneLoc Exon Structure for
PACS1
ECgene alternative splicing isoforms for
PACS1

Expression for PACS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PACS1 Gene

mRNA differential expression in normal tissues according to GTEx for PACS1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for PACS1 Gene

This gene is overexpressed in Brain (10.8), Tlymphocyte (8.2), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PACS1 Gene



Protein tissue co-expression partners for PACS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PACS1 Gene:

PACS1

SOURCE GeneReport for Unigene cluster for PACS1 Gene:

Hs.644326

Evidence on tissue expression from TISSUES for PACS1 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Liver(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PACS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • nose
  • outer ear
  • scalp
  • skull
Thorax:
  • breast
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • testicle
  • uterus
Limb:
  • foot
  • lower limb
General:
  • blood
  • blood vessel
  • hair
  • skin
genes like me logo Genes that share expression patterns with PACS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PACS1 Gene

Orthologs for PACS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PACS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PACS1 34 33
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PACS1 34 33
  • 92.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PACS1 34 33
  • 91.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pacs1 16 34 33
  • 89.84 (n)
rat
(Rattus norvegicus)
Mammalia Pacs1 33
  • 89.18 (n)
oppossum
(Monodelphis domestica)
Mammalia PACS1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PACS1 34
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves PACS1 34 33
  • 66.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PACS1 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490541 33
  • 64.48 (n)
Str.5177 33
zebrafish
(Danio rerio)
Actinopterygii pacs1a 34 33
  • 67.91 (n)
OneToMany
PACS1 (1 of 6) 34
  • 67 (a)
OneToMany
PACS1 (6 of 6) 34
  • 67 (a)
OneToMany
PACS1 (5 of 6) 34
  • 60 (a)
OneToMany
PACS1 (3 of 6) 34
  • 57 (a)
OneToMany
PACS1 (4 of 6) 34
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta KrT95D 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-232 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
Species where no ortholog for PACS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PACS1 Gene

ENSEMBL:
Gene Tree for PACS1 (if available)
TreeFam:
Gene Tree for PACS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PACS1: view image

Paralogs for PACS1 Gene

Paralogs for PACS1 Gene

(1) SIMAP similar genes for PACS1 Gene using alignment to 11 proteins:

  • PACS1_HUMAN
  • B4DF77_HUMAN
  • E9PNG7_HUMAN
  • E9PNZ9_HUMAN
  • E9PPK2_HUMAN
  • E9PSE1_HUMAN
  • E9PSG7_HUMAN
  • H0YCU5_HUMAN
  • H0YE62_HUMAN
  • H0YF56_HUMAN
  • Q9NTH2_HUMAN
genes like me logo Genes that share paralogs with PACS1: view

Variants for PACS1 Gene

Sequence variations from dbSNP and Humsavar for PACS1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs115328615 likely-benign, Schuurs-hoeijmakers syndrome 66,233,899(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs142615271 likely-benign, benign, not specified, Schuurs-hoeijmakers syndrome 66,241,451(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs369846760 uncertain-significance, Schuurs-hoeijmakers syndrome 66,241,524(+) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs398123009 conflicting-interpretations-of-pathogenicity, pathogenic, Schuurs-hoeijmakers syndrome, Multiple congenital anomalies, Inborn genetic diseases, not provided, Schuurs-Hoeijmakers syndrome (SHMS) [MIM:615009] 66,211,206(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs572697 likely-benign, benign, not specified, Schuurs-hoeijmakers syndrome 66,234,199(+) T/A coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PACS1 Gene

Variant ID Type Subtype PubMed ID
dgv220e199 CNV deletion 23128226
esv1000442 OTHER inversion 20482838
esv25273 CNV loss 19812545
esv2660282 CNV deletion 23128226
esv2661166 CNV deletion 23128226
esv2668639 CNV deletion 23128226
esv2744636 CNV deletion 23290073
esv3303782 CNV mobile element insertion 20981092
esv3305790 CNV mobile element insertion 20981092
esv3308818 CNV mobile element insertion 20981092
esv3323893 CNV insertion 20981092
esv3355386 CNV insertion 20981092
esv3445468 CNV insertion 20981092
esv3626686 CNV loss 21293372
esv3626687 CNV loss 21293372
esv3626688 CNV loss 21293372
nsv1122635 CNV deletion 24896259
nsv1127201 CNV deletion 24896259
nsv1143544 CNV deletion 24896259
nsv362 CNV deletion 18451855
nsv498760 CNV loss 21111241
nsv514631 CNV loss 21397061
nsv517090 CNV loss 19592680
nsv555222 CNV loss 21841781
nsv818843 CNV loss 17921354

Variation tolerance for PACS1 Gene

Residual Variation Intolerance Score: 4.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PACS1 Gene

Human Gene Mutation Database (HGMD)
PACS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PACS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PACS1 Gene

Disorders for PACS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PACS1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
schuurs-hoeijmakers syndrome
  • shms
pacs1-related syndrome
  • schuurs-hoeijmakers syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PACS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PACS1_HUMAN
  • Schuurs-Hoeijmakers syndrome (SHMS) [MIM:615009]: A syndromic form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. SHMS patients have intellectual disability in combination with distinct craniofacial features and genital abnormalities. {ECO:0000269 PubMed:23159249}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PACS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PACS1: view

No data available for Genatlas for PACS1 Gene

Publications for PACS1 Gene

  1. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. (PMID: 15692563) Köttgen M … Walz G (The EMBO journal 2005) 3 4 22 58
  2. Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. (PMID: 16308564) Schermer B … Benzing T (The EMBO journal 2005) 3 4 22 58
  3. Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. (PMID: 12855553) Stove V … Verhasselt B (Blood 2003) 2 3 22 58
  4. AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. (PMID: 14608369) Hinners I … Tooze SA (EMBO reports 2003) 2 3 22 58
  5. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. (PMID: 10707087) Piguet V … Trono D (Nature cell biology 2000) 3 4 22 58

Products for PACS1 Gene

Sources for PACS1 Gene

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