Aliases for PACRG Gene
External Ids for PACRG Gene
Previous GeneCards Identifiers for PACRG Gene
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PACRG Gene
PACRG (Parkin Coregulated) is a Protein Coding gene. Diseases associated with PACRG include Early-Onset Parkinson's Disease and Leprosy 3. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is PACRGL.
UniProtKB/Swiss-Prot Summary for PACRG Gene
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.