This gene represents transcription of a long non-coding RNA produced in antisense to the prostaglandin-endoperoxide synthase 2 (PTGS2) gene. This transcript interacts with NF-kB transcriptional regulators to promote expression of PTGS2. [provided by RefSeq, Feb 2015] See more...

Aliases for PACERR Gene

Subcategory (RNA class) for PACERR Gene

lncRNA

Number of RNA Genes sources:

2 / 14

Aliases for PACERR Gene

  • PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA 2 3 5
  • PTGS2 Antisense RNA 1 (Head To Head) 2 3
  • P50-Associated COX-2 Extragenic RNA 2 3
  • PACERR 2 168
  • HSALNG0009103 167
  • PTGS2-AS1 3
  • PTGS2AS1 3
  • PACER 3

External Ids for PACERR Gene

Summaries for PACERR Gene

Entrez Gene Summary for PACERR Gene

  • This gene represents transcription of a long non-coding RNA produced in antisense to the prostaglandin-endoperoxide synthase 2 (PTGS2) gene. This transcript interacts with NF-kB transcriptional regulators to promote expression of PTGS2. [provided by RefSeq, Feb 2015]

GeneCards Summary for PACERR Gene

PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with PACERR include Osteoarthritis and Osteogenic Sarcoma.

Additional gene information for PACERR Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PACERR Gene

Genomics for PACERR Gene

GeneHancer (GH) Regulatory Elements for PACERR Gene

Promoters and enhancers for PACERR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J186678 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.1 +0.1 79 4.6 TCF12 USF1 PHF8 CTCF ZIC2 POLR2A ZBTB26 EP300 ZNF341 DEK PACERR PTGS2 lnc-PDC-2 PDC-AS1 ENSG00000228238 piR-38717-002
GH01J186654 Enhancer 1 FANTOM5 Ensembl ENCODE 7.2 -23.6 -23621 8.8 ZNF316 FOS SPI1 MCM5 JUND JUN ZNF366 MAFK ZNF512 ETV6 PTGS2 TPR ODR4 PACERR ENSG00000273198 ENSG00000233196 ENSG00000228238 PLA2G4A HSALNG0009098 lnc-PDC-2
GH01J186617 Enhancer 1 FANTOM5 ENCODE 6.6 -62.1 -62099 1.2 REST BCL11A CTCF CEBPB SPI1 EZH2 BATF GABPA ELF1 MAX lnc-PTGS2-11 PTGS2 ODR4 PACERR PLA2G4A KP992443 LOC100131939 PDC-AS1
GH01J186302 Enhancer 0.9 Ensembl ENCODE 7 -375.4 -375421 9.6 CTCF SMC3 FOXA2 ZNF316 MAFF CEBPG MAFK PBX2 GATA3 FOXA1 ODR4 PACERR HSALNG0009079-001 HSALNG0009079-002 PRG4
GH01J186738 Enhancer 0.8 FANTOM5 Ensembl 7.2 +58.3 58298 1.4 BATF JUNB SPI1 NFIC CEBPB CREM MTA2 GABPA EZH2 ARID3A PTGS2 PLA2G4A PACERR ODR4 HSALNG0009106 RF00994-073
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PACERR on UCSC Golden Path with GeneCards custom track

Genomic Locations for PACERR Gene

Genomic Locations for PACERR Gene
chr1:186,680,622-186,684,913
(GRCh38/hg38)
Size:
4,292 bases
Orientation:
Plus strand
chr1:186,649,754-186,650,578
(GRCh37/hg19)
Size:
825 bases
Orientation:
Plus strand

Genomic View for PACERR Gene

Genes around PACERR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACERR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACERR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACERR Gene

Proteins for PACERR Gene

Post-translational modifications for PACERR Gene

No Post-translational modifications

No data available for DME Specific Peptides for PACERR Gene

Domains & Families for PACERR Gene

Gene Families for PACERR Gene

genes like me logo Genes that share domains with PACERR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PACERR Gene

Function for PACERR Gene

Phenotypes From GWAS Catalog for PACERR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PACERR Gene

Localization for PACERR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PACERR Gene

Pathways & Interactions for PACERR Gene

PathCards logo

SuperPathways for PACERR Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for PACERR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for PACERR Gene

Drugs & Compounds for PACERR Gene

No Compound Related Data Available

Transcripts for PACERR Gene

mRNA/cDNA for PACERR Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
1 LncBook transcripts :
4 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for PACERR Gene

No ASD Table

Relevant External Links for PACERR Gene

GeneLoc Exon Structure for
PACERR

Expression for PACERR Gene

Evidence on tissue expression from TISSUES for PACERR Gene

  • Heart(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PACERR Gene

Orthologs for PACERR Gene

Evolution for PACERR Gene

ENSEMBL:
Gene Tree for PACERR (if available)
TreeFam:
Gene Tree for PACERR (if available)

No data available for Orthologs for PACERR Gene

Paralogs for PACERR Gene

No data available for Paralogs for PACERR Gene

Variants for PACERR Gene

Additional dbSNP identifiers (rs#s) for PACERR Gene

Structural Variations from Database of Genomic Variants (DGV) for PACERR Gene

Variant ID Type Subtype PubMed ID
esv2762854 CNV gain 21179565
nsv470750 CNV loss 18288195
nsv548403 CNV loss 21841781

Additional Variant Information for PACERR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PACERR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for PACERR Gene

Disorders for PACERR Gene

MalaCards: The human disease database

(2) MalaCards diseases for PACERR Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
osteoarthritis
  • kashin-beck disease
osteogenic sarcoma
  • osteosarcoma; osrc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PACERR

genes like me logo Genes that share disorders with PACERR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PACERR Gene

Publications for PACERR Gene

  1. p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes. (PMID: 24843008) Krawczyk M … Emerson BM (eLife 2014) 2 3 54
  2. P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene. (PMID: 26476537) Qian M … Xiao J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 54
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 54

Products for PACERR Gene

Sources for PACERR Gene