Aliases for PABPN1L Gene

Aliases for PABPN1L Gene

  • PABPN1 Like, Cytoplasmic 2 3 5
  • EPABP2 2 3 4 4
  • Poly(A) Binding Protein Nuclear 1 Like, Cytoplasmic 2 3
  • Embryonic Polyadenylate-Binding Protein 2 3 4
  • Embryonic Poly(A)-Binding Protein Type II 3 4
  • Poly(A)-Binding Protein Nuclear-Like 1 3 4
  • Embryonic Poly(A)-Binding Protein 2 3 4
  • PABPNL1 3 4
  • EPABP-2 3 4
  • Poly(A) Binding Protein Nuclear 1 Like (Cytoplasmic) 2
  • Embryonic Poly(A) Binding Protein 2 2
  • PABPN1L 5

External Ids for PABPN1L Gene

Previous GeneCards Identifiers for PABPN1L Gene

  • GC16M087456
  • GC16M088928
  • GC16M074625

Summaries for PABPN1L Gene

GeneCards Summary for PABPN1L Gene

PABPN1L (PABPN1 Like, Cytoplasmic) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Measles. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPN1.

UniProtKB/Swiss-Prot Summary for PABPN1L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PABPN1L Gene

Genomics for PABPN1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PABPN1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PABPN1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PABPN1L

Genomic Locations for PABPN1L Gene

Latest Assembly
chr16:88,863,333-88,870,152
(GRCh38/hg38)
Size:
6,820 bases
Orientation:
Minus strand

Previous Assembly
chr16:88,929,741-88,936,560
(GRCh37/hg19 by Entrez Gene)
Size:
6,820 bases
Orientation:
Minus strand

chr16:88,928,034-88,933,068
(GRCh37/hg19 by Ensembl)
Size:
5,035 bases
Orientation:
Minus strand

Genomic View for PABPN1L Gene

Genes around PABPN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPN1L Gene

Proteins for PABPN1L Gene

  • Protein details for PABPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDY0-EPAB2_HUMAN
    Recommended name:
    Embryonic polyadenylate-binding protein 2
    Protein Accession:
    A6NDY0
    Secondary Accessions:
    • A1L3B3
    • A2VDI2

    Protein attributes for PABPN1L Gene

    Size:
    278 amino acids
    Molecular mass:
    30386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPN1L Gene

Post-translational modifications for PABPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPN1L Gene

No data available for DME Specific Peptides for PABPN1L Gene

Domains & Families for PABPN1L Gene

Gene Families for PABPN1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPN1L Gene

Suggested Antigen Peptide Sequences for PABPN1L Gene

GenScript: Design optimal peptide antigens:
  • Poly(A)-binding protein nuclear-like 1 (EPAB2_HUMAN)
genes like me logo Genes that share domains with PABPN1L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PABPN1L Gene

Function for PABPN1L Gene

Molecular function for PABPN1L Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA.

Phenotypes From GWAS Catalog for PABPN1L Gene

Gene Ontology (GO) - Molecular Function for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPN1L: view
genes like me logo Genes that share phenotypes with PABPN1L: view

Animal Models for PABPN1L Gene

MGI Knock Outs for PABPN1L:
  • Pabpn1l Pabpn1l<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPN1L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PABPN1L Gene

Localization for PABPN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPN1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPN1L gene
Compartment Confidence
nucleus 3
cytosol 0

Gene Ontology (GO) - Cellular Components for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PABPN1L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PABPN1L Gene

Pathways & Interactions for PABPN1L Gene

PathCards logo

SuperPathways for PABPN1L Gene

SuperPathway Contained pathways
1 Measles
2 mRNA surveillance pathway
genes like me logo Genes that share pathways with PABPN1L: view

Pathways by source for PABPN1L Gene

2 KEGG pathways for PABPN1L Gene

Interacting Proteins for PABPN1L Gene

Gene Ontology (GO) - Biological Process for PABPN1L Gene

None

No data available for SIGNOR curated interactions for PABPN1L Gene

Drugs & Compounds for PABPN1L Gene

No Compound Related Data Available

Transcripts for PABPN1L Gene

mRNA/cDNA for PABPN1L Gene

3 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPN1L

Alternative Splicing Database (ASD) splice patterns (SP) for PABPN1L Gene

No ASD Table

Relevant External Links for PABPN1L Gene

GeneLoc Exon Structure for
PABPN1L

Expression for PABPN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PABPN1L Gene

mRNA differential expression in normal tissues according to GTEx for PABPN1L Gene

This gene is overexpressed in Brain - Cerebellum (x8.5), Brain - Cerebellar Hemisphere (x6.5), and Adrenal Gland (x5.6).

Protein differential expression in normal tissues from HIPED for PABPN1L Gene

This gene is overexpressed in Liver (35.7) and Urine (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PABPN1L Gene



Protein tissue co-expression partners for PABPN1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PABPN1L

SOURCE GeneReport for Unigene cluster for PABPN1L Gene:

Hs.730522

mRNA Expression by UniProt/SwissProt for PABPN1L Gene:

A6NDY0-EPAB2_HUMAN
Tissue specificity: Expressed in various adult tissues.
genes like me logo Genes that share expression patterns with PABPN1L: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPN1L Gene

Orthologs for PABPN1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPN1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PABPN1L 30 31
  • 99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PABPN1L 30 31
  • 82.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pabpn1l 30
  • 75.5 (n)
Mouse
(Mus musculus)
Mammalia Pabpn1l 30 17 31
  • 73.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PABPN1L 31
  • 55 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PABPN1L 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PABPN1L 31
  • 47 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PABPN1L 31
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pabpn1l 31
  • 42 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pabp2 31
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea pabp-2 31
  • 42 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGN1 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1647 31
  • 45 (a)
OneToMany
Species where no ortholog for PABPN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PABPN1L Gene

ENSEMBL:
Gene Tree for PABPN1L (if available)
TreeFam:
Gene Tree for PABPN1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PABPN1L: view image

Paralogs for PABPN1L Gene

Paralogs for PABPN1L Gene

(1) SIMAP similar genes for PABPN1L Gene using alignment to 2 proteins:

  • EPAB2_HUMAN
  • C9JEK9_HUMAN
genes like me logo Genes that share paralogs with PABPN1L: view

Variants for PABPN1L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PABPN1L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PABPN1L Gene

Variant ID Type Subtype PubMed ID
dgv3065n100 CNV gain 25217958
dgv37n68 CNV loss 17160897
esv2715064 CNV deletion 23290073
esv2715066 CNV deletion 23290073
esv3639555 CNV gain 21293372
esv3639561 CNV gain 21293372
nsv1061256 CNV gain 25217958
nsv1063024 CNV gain 25217958
nsv1928 CNV insertion 18451855
nsv471115 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv521217 CNV loss 19592680
nsv573674 CNV gain 21841781
nsv952071 CNV deletion 24416366

Variation tolerance for PABPN1L Gene

Gene Damage Index Score: 3.20; 52.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PABPN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPN1L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PABPN1L Gene

Disorders for PABPN1L Gene

Additional Disease Information for PABPN1L

No disorders were found for PABPN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPN1L Gene

Publications for PABPN1L Gene

  1. Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns. (PMID: 18483763) Sakugawa N … Sengoku K (Journal of assisted reproduction and genetics 2008) 2 3 4
  2. Heritability of human visual contour integration-an integrated genomic study. (PMID: 31363184) Zhu Z … Fang F (European journal of human genetics : EJHG 2019) 3
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development. (PMID: 15083517) Good PJ … Sheets MD (Genesis (New York, N.Y. : 2000) 2004) 3

Products for PABPN1L Gene

Sources for PABPN1L Gene