This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints a... See more...

Aliases for PABPC5 Gene

Aliases for PABPC5 Gene

  • Poly(A) Binding Protein Cytoplasmic 5 2 3 5
  • PABP5 2 3 4
  • Polyadenylate-Binding Protein 5 3 4
  • Poly(A)-Binding Protein, Cytoplasmic 5 2
  • Poly(A)-Binding Protein 5 4
  • PABPC5 5
  • PABP-5 4

External Ids for PABPC5 Gene

Previous GeneCards Identifiers for PABPC5 Gene

  • GC0XP085962
  • GC0XP087658
  • GC0XP088725
  • GC0XP089461
  • GC0XP090495
  • GC0XP090576
  • GC0XP090689

Summaries for PABPC5 Gene

Entrez Gene Summary for PABPC5 Gene

  • This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

GeneCards Summary for PABPC5 Gene

PABPC5 (Poly(A) Binding Protein Cytoplasmic 5) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC4.

UniProtKB/Swiss-Prot Summary for PABPC5 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Additional gene information for PABPC5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PABPC5 Gene

Genomics for PABPC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PABPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ091434 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 604.9 +0.8 777 2.5 POLR2A RXRA CHD2 TAF1 PABPC5 PABPC5-AS1 RF00017-8563 piR-56883-208 PCDH11X
GH0XJ091424 Enhancer 0.2 FANTOM5 0.4 -10.3 -10266 0.2 LOC100287033 PABPC5 PABPC5-AS1 RF00017-8563
GH0XJ091486 Enhancer 0.2 Ensembl 0.2 +52.4 52406 0.4 piR-56883-208 piR-47402-046 PABPC5 RF00017-8563 PCDH11X
GH0XJ091496 Enhancer 0.2 Ensembl 0.2 +62.6 62606 0.8 piR-47402-046 piR-56883-208 PABPC5 RF00017-8563 PCDH11X
GH0XJ091500 Enhancer 0.2 Ensembl 0.2 +65.5 65506 0.2 piR-47402-046 piR-56883-208 PABPC5 RF00017-8563 PCDH11X
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PABPC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PABPC5

Top Transcription factor binding sites by QIAGEN in the PABPC5 gene promoter:
  • AhR
  • AML1a
  • CREB
  • Elk-1
  • FOXF2
  • POU2F1
  • POU2F1a
  • RORalpha2
  • Zic1

Genomic Locations for PABPC5 Gene

Genomic Locations for PABPC5 Gene
chrX:91,434,595-91,438,584
(GRCh38/hg38)
Size:
3,990 bases
Orientation:
Plus strand
chrX:90,689,594-90,693,583
(GRCh37/hg19)
Size:
3,990 bases
Orientation:
Plus strand

Genomic View for PABPC5 Gene

Genes around PABPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC5 Gene

Proteins for PABPC5 Gene

  • Protein details for PABPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DU9-PABP5_HUMAN
    Recommended name:
    Polyadenylate-binding protein 5
    Protein Accession:
    Q96DU9
    Secondary Accessions:
    • A8K240
    • Q5JQF4
    • Q6P529
    • Q9UFE5

    Protein attributes for PABPC5 Gene

    Size:
    382 amino acids
    Molecular mass:
    43331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC5 Gene

Post-translational modifications for PABPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC5 Gene

Domains & Families for PABPC5 Gene

Gene Families for PABPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPC5 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for PABPC5 Gene

GenScript: Design optimal peptide antigens:
  • Polyadenylate-binding protein 5 (PABP5_HUMAN)
genes like me logo Genes that share domains with PABPC5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PABPC5 Gene

Function for PABPC5 Gene

Molecular function for PABPC5 Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Phenotypes From GWAS Catalog for PABPC5 Gene

Gene Ontology (GO) - Molecular Function for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003730 mRNA 3'-UTR binding IBA 21873635
GO:0008143 poly(A) binding IBA 21873635
GO:0008266 poly(U) RNA binding IBA 21873635
genes like me logo Genes that share ontologies with PABPC5: view
genes like me logo Genes that share phenotypes with PABPC5: view

Animal Model Products

CRISPR Products

miRNA for PABPC5 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC5 Gene

Localization for PABPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC5 Gene

Cytoplasm.
[Isoform 2]: Mitochondrion matrix. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC5 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with PABPC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PABPC5 Gene

Pathways & Interactions for PABPC5 Gene

genes like me logo Genes that share pathways with PABPC5: view

Pathways by source for PABPC5 Gene

3 KEGG pathways for PABPC5 Gene

Gene Ontology (GO) - Biological Process for PABPC5 Gene

None

No data available for SIGNOR curated interactions for PABPC5 Gene

Drugs & Compounds for PABPC5 Gene

No Compound Related Data Available

Transcripts for PABPC5 Gene

mRNA/cDNA for PABPC5 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC5

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC5 Gene

No ASD Table

Relevant External Links for PABPC5 Gene

GeneLoc Exon Structure for
PABPC5

Expression for PABPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PABPC5 Gene

Protein differential expression in normal tissues from HIPED for PABPC5 Gene

This gene is overexpressed in Ovary (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PABPC5 Gene



Protein tissue co-expression partners for PABPC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PABPC5

SOURCE GeneReport for Unigene cluster for PABPC5 Gene:

Hs.246590

mRNA Expression by UniProt/SwissProt for PABPC5 Gene:

Q96DU9-PABP5_HUMAN
Tissue specificity: Expressed in fetal brain and in a range of adult tissues.

Evidence on tissue expression from TISSUES for PABPC5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PABPC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC5 Gene

Orthologs for PABPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PABPC5 30 31
  • 99.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PABPC5 31
  • 97 (a)
OneToOne
LOC511286 30
  • 91.95 (n)
Dog
(Canis familiaris)
Mammalia PABPC5 30 31
  • 92.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pabpc5 30
  • 89.24 (n)
Mouse
(Mus musculus)
Mammalia Pabpc5 30 17 31
  • 88.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii pabpc4 31
  • 40 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG4612 32
  • 44 (a)
Species where no ortholog for PABPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PABPC5 Gene

ENSEMBL:
Gene Tree for PABPC5 (if available)
TreeFam:
Gene Tree for PABPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PABPC5: view image

Paralogs for PABPC5 Gene

(8) SIMAP similar genes for PABPC5 Gene using alignment to 2 proteins:

  • PABP5_HUMAN
  • Q5JQF3_HUMAN
genes like me logo Genes that share paralogs with PABPC5: view

Variants for PABPC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PABPC5 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs7050077 - p.Asn314Ser

Additional dbSNP identifiers (rs#s) for PABPC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PABPC5 Gene

Variant ID Type Subtype PubMed ID
nsv516611 CNV gain 19592680
nsv521121 CNV gain 19592680
nsv526620 CNV gain 19592680
nsv528258 CNV gain 19592680

Variation tolerance for PABPC5 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PABPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC5 Gene

Disorders for PABPC5 Gene

No disorders were found for PABPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC5 Gene

Publications for PABPC5 Gene

  1. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. (PMID: 11374897) Blanco P … Affara NA (Genomics 2001) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3

Products for PABPC5 Gene

Sources for PABPC5 Gene