Aliases for PABPC4L Gene

Aliases for PABPC4L Gene

  • Poly(A) Binding Protein Cytoplasmic 4 Like 2 3 5
  • Polyadenylate-Binding Protein 4-Like 3 4
  • PABP-4-Like 3 4
  • Poly(A) Binding Protein, Cytoplasmic 4-Like 2
  • Poly(A)-Binding Protein 4-Like 4
  • PABPC4L 5

External Ids for PABPC4L Gene

Previous GeneCards Identifiers for PABPC4L Gene

  • GC00U921646
  • GC04M135336
  • GC04M135117
  • GC04M130845
  • GC04M134196

Summaries for PABPC4L Gene

GeneCards Summary for PABPC4L Gene

PABPC4L (Poly(A) Binding Protein Cytoplasmic 4 Like) is a Protein Coding gene. Diseases associated with PABPC4L include Apical Myocardial Infarction. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC4.

UniProtKB/Swiss-Prot Summary for PABPC4L Gene

Additional gene information for PABPC4L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PABPC4L Gene

Genomics for PABPC4L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PABPC4L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J134196 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 6.5 +2.2 2204 6 ZNF24 CEBPB ZFX FOXM1 NFIB PRDM10 GATA3 ZNF217 TAF1 L3MBTL2 PABPC4L ENSG00000251199 ENSG00000251388
GH04J134544 Enhancer 0.7 Ensembl ENCODE 4.5 -342.7 -342712 0.6 ESR1 CEBPB JUND EP300 STAT1 STAT3 HIC1 TRIM28 PKNOX1 PABPC4L lnc-PABPC4L-18 lnc-PABPC4L-20 piR-50129-194 LINC02462
GH04J134552 Enhancer 0.6 Ensembl ENCODE 4.5 -350.2 -350212 2 USF1 NANOG SP1 POU5F1 PABPC4L LINC02462 lnc-PABPC4L-18 lnc-PABPC4L-20 piR-50129-194
GH04J134215 Enhancer 0.4 Ensembl 6.2 -14.7 -14712 1 SP1 CEBPB FOSL2 PABPC4L PES1P1 ENSG00000251199
GH04J134145 Enhancer 0.3 Ensembl 6 +56.3 56288 1 NANOG PABPC4L ENSG00000251388 ENSG00000251199 PCDH10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PABPC4L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PABPC4L

Top Transcription factor binding sites by QIAGEN in the PABPC4L gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • E2F
  • E2F-1
  • Nkx2-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT5A

Genomic Locations for PABPC4L Gene

Genomic Locations for PABPC4L Gene
253,331 bases
Minus strand
5,416 bases
Minus strand

Genomic View for PABPC4L Gene

Genes around PABPC4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4L Gene

Proteins for PABPC4L Gene

  • Protein details for PABPC4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polyadenylate-binding protein 4-like
    Protein Accession:

    Protein attributes for PABPC4L Gene

    370 amino acids
    Molecular mass:
    41854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PABPC4L Gene

Post-translational modifications for PABPC4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC4L Gene

Domains & Families for PABPC4L Gene

Gene Families for PABPC4L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPC4L Gene

Suggested Antigen Peptide Sequences for PABPC4L Gene

GenScript: Design optimal peptide antigens:
  • Polyadenylate-binding protein 4-like (PAB4L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the polyadenylate-binding protein type-1 family.
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC4L: view

Function for PABPC4L Gene

Molecular function for PABPC4L Gene

UniProtKB/Swiss-Prot Function:
May bind RNA.

Phenotypes From GWAS Catalog for PABPC4L Gene

Gene Ontology (GO) - Molecular Function for PABPC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003730 mRNA 3'-UTR binding IBA 21873635
GO:0008143 poly(A) binding IBA 21873635
GO:0008266 poly(U) RNA binding IBA 21873635
genes like me logo Genes that share ontologies with PABPC4L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC4L

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC4L Gene

Localization for PABPC4L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC4L gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PABPC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0010494 cytoplasmic stress granule IBA 21873635
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with PABPC4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PABPC4L Gene

Pathways & Interactions for PABPC4L Gene

genes like me logo Genes that share pathways with PABPC4L: view

Pathways by source for PABPC4L Gene

3 KEGG pathways for PABPC4L Gene

Gene Ontology (GO) - Biological Process for PABPC4L Gene


No data available for SIGNOR curated interactions for PABPC4L Gene

Drugs & Compounds for PABPC4L Gene

No Compound Related Data Available

Transcripts for PABPC4L Gene

mRNA/cDNA for PABPC4L Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC4L

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4L Gene

No ASD Table

Relevant External Links for PABPC4L Gene

GeneLoc Exon Structure for

Expression for PABPC4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PABPC4L Gene

mRNA differential expression in normal tissues according to GTEx for PABPC4L Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.4).

Protein differential expression in normal tissues from HIPED for PABPC4L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PABPC4L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PABPC4L

SOURCE GeneReport for Unigene cluster for PABPC4L Gene:

genes like me logo Genes that share expression patterns with PABPC4L: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC4L Gene

Orthologs for PABPC4L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PABPC4L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PABPC4L 30
  • 99.53 (n)
(Bos Taurus)
Mammalia LOC101908085 30
  • 88.35 (n)
(Mus musculus)
Mammalia Pabpc4l 30 17 31
  • 81.26 (n)
(Rattus norvegicus)
Mammalia Pabpc4l 30
  • 80.99 (n)
(Canis familiaris)
Mammalia PABPC4L 30
  • 71.54 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
(Danio rerio)
Actinopterygii pabpc4 31
  • 46 (a)
Species where no ortholog for PABPC4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PABPC4L Gene

Gene Tree for PABPC4L (if available)
Gene Tree for PABPC4L (if available)
Evolutionary constrained regions (ECRs) for PABPC4L: view image

Paralogs for PABPC4L Gene

(14) SIMAP similar genes for PABPC4L Gene using alignment to 3 proteins:

  • L8E9S0_HUMAN
genes like me logo Genes that share paralogs with PABPC4L: view

Variants for PABPC4L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PABPC4L Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs10009368 - p.Val192Ile
rs11099273 - p.His370Pro
rs6830036 - p.Ser331Asn

Additional dbSNP identifiers (rs#s) for PABPC4L Gene

Structural Variations from Database of Genomic Variants (DGV) for PABPC4L Gene

Variant ID Type Subtype PubMed ID
dgv5397n100 CNV loss 25217958
dgv9275n54 CNV loss 21841781
dgv9276n54 CNV loss 21841781
dgv9277n54 CNV loss 21841781
esv3569696 CNV loss 25503493
esv3569699 CNV loss 25503493
esv3602304 CNV loss 21293372
nsv1026397 CNV loss 25217958
nsv461648 CNV loss 19166990
nsv520680 CNV loss 19592680
nsv595493 CNV loss 21841781

Variation tolerance for PABPC4L Gene

Gene Damage Index Score: 2.17; 39.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PABPC4L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC4L Gene

Disorders for PABPC4L Gene

MalaCards: The human disease database

(1) MalaCards diseases for PABPC4L Gene - From: DISEASES

Disorder Aliases PubMed IDs
apical myocardial infarction
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PABPC4L

genes like me logo Genes that share disorders with PABPC4L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PABPC4L Gene

Publications for PABPC4L Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  4. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. (PMID: 23754948) Randall JC … Heid IM (PLoS genetics 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PABPC4L Gene

Sources for PABPC4L Gene