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Aliases for PABPC1L2B Gene

Aliases for PABPC1L2B Gene

  • Poly(A) Binding Protein Cytoplasmic 1 Like 2B 2 3 5
  • RNA Binding Motif Protein 32B 2 3
  • RNA-Binding Motif Protein 32 3 4
  • RNA-Binding Protein 32 3 4
  • RBM32B 3 4
  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2B 2
  • Polyadenylate-Binding Protein 1-Like 2 3
  • PABPC1L2 4
  • RBM32A 4

External Ids for PABPC1L2B Gene

Previous HGNC Symbols for PABPC1L2B Gene

  • RBM32B

Previous GeneCards Identifiers for PABPC1L2B Gene

  • GC0XP072139
  • GC0XP072223
  • GC0XP065860

Summaries for PABPC1L2B Gene

GeneCards Summary for PABPC1L2B Gene

PABPC1L2B (Poly(A) Binding Protein Cytoplasmic 1 Like 2B) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

Additional gene information for PABPC1L2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L2B Gene

Genomics for PABPC1L2B Gene

GeneHancer (GH) Regulatory Elements for PABPC1L2B Gene

Promoters and enhancers for PABPC1L2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI073003 Promoter 0.5 EPDnew 550.8 +0.0 14 0.1 PABPC1L2B PABPC1L2B-AS1 GC0XP073077
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PABPC1L2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PABPC1L2B gene promoter:

Genomic Locations for PABPC1L2B Gene

Genomic Locations for PABPC1L2B Gene
2,201 bases
Plus strand

Genomic View for PABPC1L2B Gene

Genes around PABPC1L2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC1L2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC1L2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L2B Gene

Proteins for PABPC1L2B Gene

  • Protein details for PABPC1L2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polyadenylate-binding protein 1-like 2
    Protein Accession:
    Secondary Accessions:
    • B2RMV9
    • Q8IVU8

    Protein attributes for PABPC1L2B Gene

    200 amino acids
    Molecular mass:
    22799 Da
    Quaternary structure:
    No Data Available
    • May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.
    • Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PABPC1L2B Gene

Post-translational modifications for PABPC1L2B Gene

No Post-translational modifications

Other Protein References for PABPC1L2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC1L2B Gene

Domains & Families for PABPC1L2B Gene

Gene Families for PABPC1L2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPC1L2B Gene


Suggested Antigen Peptide Sequences for PABPC1L2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PABPC1L2B: view

No data available for UniProtKB/Swiss-Prot for PABPC1L2B Gene

Function for PABPC1L2B Gene

Phenotypes From GWAS Catalog for PABPC1L2B Gene

Gene Ontology (GO) - Molecular Function for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC1L2B: view

Phenotypes for PABPC1L2B Gene

GenomeRNAi human phenotypes for PABPC1L2B:
genes like me logo Genes that share phenotypes with PABPC1L2B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC1L2B Gene

Localization for PABPC1L2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC1L2B gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with PABPC1L2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PABPC1L2B Gene

Pathways & Interactions for PABPC1L2B Gene

genes like me logo Genes that share pathways with PABPC1L2B: view

Pathways by source for PABPC1L2B Gene

3 KEGG pathways for PABPC1L2B Gene

Gene Ontology (GO) - Biological Process for PABPC1L2B Gene


No data available for SIGNOR curated interactions for PABPC1L2B Gene

Drugs & Compounds for PABPC1L2B Gene

No Compound Related Data Available

Transcripts for PABPC1L2B Gene

mRNA/cDNA for PABPC1L2B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L2B Gene

Poly(A) binding protein, cytoplasmic 1-like 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L2B Gene

No ASD Table

Relevant External Links for PABPC1L2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PABPC1L2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PABPC1L2B Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L2B Gene

This gene is overexpressed in Brain - Hypothalamus (x7.1), Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for PABPC1L2B Gene

This gene is overexpressed in Tlymphocyte (28.5), Heart (18.4), Brain (12.4), and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PABPC1L2B Gene

Protein tissue co-expression partners for PABPC1L2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PABPC1L2B Gene:


SOURCE GeneReport for Unigene cluster for PABPC1L2B Gene:


Evidence on tissue expression from TISSUES for PABPC1L2B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PABPC1L2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC1L2B Gene

Orthologs for PABPC1L2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPC1L2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
-- 34
  • 99 (a)
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSH49 34
  • 21 (a)
Species where no ortholog for PABPC1L2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PABPC1L2B Gene

Gene Tree for PABPC1L2B (if available)
Gene Tree for PABPC1L2B (if available)

Paralogs for PABPC1L2B Gene

(11) SIMAP similar genes for PABPC1L2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PABPC1L2B: view

Variants for PABPC1L2B Gene

Sequence variations from dbSNP and Humsavar for PABPC1L2B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1006550220 -- 73,006,126(+) T/C downstream_transcript_variant
rs1006600665 -- 73,005,638(+) A/G 3_prime_UTR_variant
rs1029301298 -- 73,005,627(+) T/C 3_prime_UTR_variant
rs1032691082 -- 73,006,132(+) A/G downstream_transcript_variant
rs1033325705 -- 73,005,639(+) C/G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L2B Gene

Variant ID Type Subtype PubMed ID
dgv1253n67 CNV gain 20364138
nsv1076264 CNV deletion 25765185
nsv499562 OTHER inversion 21111241
nsv508782 CNV insertion 20534489
nsv7451 OTHER inversion 18451855
nsv829379 CNV gain 20364138

Additional Variant Information for PABPC1L2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PABPC1L2B Gene

Disorders for PABPC1L2B Gene

Additional Disease Information for PABPC1L2B

No disorders were found for PABPC1L2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC1L2B Gene

Publications for PABPC1L2B Gene

  1. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for PABPC1L2B Gene

Sources for PABPC1L2B Gene

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