Aliases for PABPC1L2B Gene

Aliases for PABPC1L2B Gene

  • Poly(A) Binding Protein Cytoplasmic 1 Like 2B 2 3 5
  • Polyadenylate-Binding Protein 1-Like 2 3 4
  • RNA Binding Motif Protein 32B 2 3
  • RNA-Binding Motif Protein 32 3 4
  • RNA-Binding Protein 32 3 4
  • RBM32B 3 4
  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2B 2
  • PABPC1L2B 5
  • PABPC1L2 4
  • RBM32A 4

External Ids for PABPC1L2B Gene

Previous HGNC Symbols for PABPC1L2B Gene

  • RBM32B

Previous GeneCards Identifiers for PABPC1L2B Gene

  • GC0XP072139
  • GC0XP072223
  • GC0XP065860

Summaries for PABPC1L2B Gene

GeneCards Summary for PABPC1L2B Gene

PABPC1L2B (Poly(A) Binding Protein Cytoplasmic 1 Like 2B) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

Additional gene information for PABPC1L2B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PABPC1L2B Gene

Genomics for PABPC1L2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PABPC1L2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ073002 Promoter 0.3 Ensembl 600.7 +0.4 362 1.4 PABPC1L2B PABPC1L2B-AS1 piR-55655-610 PABPC1L2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PABPC1L2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PABPC1L2B

Top Transcription factor binding sites by QIAGEN in the PABPC1L2B gene promoter:
  • AML1a
  • c-Myb
  • CREB
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for PABPC1L2B Gene

Genomic Locations for PABPC1L2B Gene
chrX:73,002,939-73,006,106
(GRCh38/hg38)
Size:
3,168 bases
Orientation:
Plus strand
chrX:72,223,352-72,225,551
(GRCh37/hg19)
Size:
2,200 bases
Orientation:
Plus strand

Genomic View for PABPC1L2B Gene

Genes around PABPC1L2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC1L2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC1L2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L2B Gene

Proteins for PABPC1L2B Gene

  • Protein details for PABPC1L2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQF8-PAP1M_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like 2
    Protein Accession:
    Q5JQF8
    Secondary Accessions:
    • B2RMV9
    • Q8IVU8

    Protein attributes for PABPC1L2B Gene

    Size:
    200 amino acids
    Molecular mass:
    22799 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.

neXtProt entry for PABPC1L2B Gene

Post-translational modifications for PABPC1L2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC1L2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC1L2B Gene

Domains & Families for PABPC1L2B Gene

Gene Families for PABPC1L2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPC1L2B Gene

Suggested Antigen Peptide Sequences for PABPC1L2B Gene

GenScript: Design optimal peptide antigens:
  • RNA-binding protein 32 (PAP1M_HUMAN)
genes like me logo Genes that share domains with PABPC1L2B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PABPC1L2B Gene

Function for PABPC1L2B Gene

Phenotypes From GWAS Catalog for PABPC1L2B Gene

Gene Ontology (GO) - Molecular Function for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC1L2B: view
genes like me logo Genes that share phenotypes with PABPC1L2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC1L2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC1L2B Gene

Localization for PABPC1L2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC1L2B gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PABPC1L2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PABPC1L2B Gene

Pathways & Interactions for PABPC1L2B Gene

PathCards logo

SuperPathways for PABPC1L2B Gene

genes like me logo Genes that share pathways with PABPC1L2B: view

Pathways by source for PABPC1L2B Gene

3 KEGG pathways for PABPC1L2B Gene

Gene Ontology (GO) - Biological Process for PABPC1L2B Gene

None

No data available for SIGNOR curated interactions for PABPC1L2B Gene

Drugs & Compounds for PABPC1L2B Gene

No Compound Related Data Available

Transcripts for PABPC1L2B Gene

mRNA/cDNA for PABPC1L2B Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC1L2B

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L2B Gene

No ASD Table

Relevant External Links for PABPC1L2B Gene

GeneLoc Exon Structure for
PABPC1L2B

Expression for PABPC1L2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PABPC1L2B Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L2B Gene

This gene is overexpressed in Brain - Hypothalamus (x7.1), Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for PABPC1L2B Gene

This gene is overexpressed in Tlymphocyte (28.5), Heart (18.4), Brain (12.4), and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PABPC1L2B Gene



Protein tissue co-expression partners for PABPC1L2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PABPC1L2B

SOURCE GeneReport for Unigene cluster for PABPC1L2B Gene:

Hs.567854

Evidence on tissue expression from TISSUES for PABPC1L2B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PABPC1L2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC1L2B Gene

Orthologs for PABPC1L2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPC1L2B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 99 (a)
ManyToMany
-- 31
  • 99 (a)
ManyToMany
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 21 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSH49 31
  • 21 (a)
OneToMany
Species where no ortholog for PABPC1L2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PABPC1L2B Gene

ENSEMBL:
Gene Tree for PABPC1L2B (if available)
TreeFam:
Gene Tree for PABPC1L2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PABPC1L2B: view image

Paralogs for PABPC1L2B Gene

(11) SIMAP similar genes for PABPC1L2B Gene using alignment to 1 proteins:

  • PAP1M_HUMAN
genes like me logo Genes that share paralogs with PABPC1L2B: view

Variants for PABPC1L2B Gene

Additional dbSNP identifiers (rs#s) for PABPC1L2B Gene

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L2B Gene

Variant ID Type Subtype PubMed ID
dgv1253n67 CNV gain 20364138
nsv1076264 CNV deletion 25765185
nsv499562 OTHER inversion 21111241
nsv508782 CNV insertion 20534489
nsv7451 OTHER inversion 18451855
nsv829379 CNV gain 20364138

Additional Variant Information for PABPC1L2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC1L2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for PABPC1L2B Gene

Disorders for PABPC1L2B Gene

No disorders were found for PABPC1L2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC1L2B Gene

Publications for PABPC1L2B Gene

  1. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for PABPC1L2B Gene

Sources for PABPC1L2B Gene