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Aliases for PA2G4 Gene

Aliases for PA2G4 Gene

  • Proliferation-Associated 2G4 2 3 5
  • Proliferation-Associated 2G4, 38kDa 2 3
  • Proliferation-Associated 2G4, 38kD 2 3
  • Cell Cycle Protein P38-2G4 Homolog 3 4
  • ErbB3-Binding Protein 1 3 4
  • HG4-1 3 4
  • EBP1 3 4
  • Proliferation-Associated Protein 2G4 3
  • ErbB3-Binding Protein Ebp1 3
  • ErbB-3 Binding Protein 1 3
  • P38-2G4 3

External Ids for PA2G4 Gene

Previous GeneCards Identifiers for PA2G4 Gene

  • GC12M056378
  • GC12M056832
  • GC12P056215
  • GC12P054784
  • GC12P056498
  • GC12P053543

Summaries for PA2G4 Gene

Entrez Gene Summary for PA2G4 Gene

  • This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PA2G4 Gene

PA2G4 (Proliferation-Associated 2G4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot for PA2G4 Gene

  • May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Gene Wiki entry for PA2G4 Gene

Additional gene information for PA2G4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PA2G4 Gene

Genomics for PA2G4 Gene

GeneHancer (GH) Regulatory Elements for PA2G4 Gene

Promoters and enhancers for PA2G4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056102 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 465 5.4 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC MEF2D GC12M056105 LOC105369782 PA2G4 BAZ2A NEMP1 ENSG00000257740 SMARCC2 DNAJC14 RN7SL809P IKZF4
GH12I056298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.6 +196.5 196491 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000257303 CS BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41 MMP19
GH12I056114 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12.2 +14.0 14005 6.8 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZC3H10 RPL41 ESYT1 ENSG00000258345 GC12M056121 PIR42205 BAZ2A NEMP1 RN7SL809P DNAJC14
GH12I056156 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +55.6 55616 6.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 NFYC ZFP41 MEF2D ENSG00000257809 MYL6 NEMP1 BAZ2A DNAJC14 TMEM198B ZC3H10 RN7SL809P ENSG00000257740 SMARCC2
GH12I056187 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.6 +85.1 85137 3.5 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZNF610 ENSG00000258199 SMARCC2 GC12P056192 TRS-CGA4-1 NEMP1 ENSG00000257740 IKZF4 ANKRD52 PHC1P1 BAZ2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PA2G4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PA2G4 gene promoter:

Genomic Locations for PA2G4 Gene

Genomic Locations for PA2G4 Gene
chr12:56,104,319-56,113,910
(GRCh38/hg38)
Size:
9,592 bases
Orientation:
Plus strand
chr12:56,498,103-56,507,694
(GRCh37/hg19)

Genomic View for PA2G4 Gene

Genes around PA2G4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PA2G4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PA2G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PA2G4 Gene

Proteins for PA2G4 Gene

  • Protein details for PA2G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ80-PA2G4_HUMAN
    Recommended name:
    Proliferation-associated protein 2G4
    Protein Accession:
    Q9UQ80
    Secondary Accessions:
    • O43846
    • Q9UM59

    Protein attributes for PA2G4 Gene

    Size:
    394 amino acids
    Molecular mass:
    43787 Da
    Quaternary structure:
    • Isoform 2 interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Interacts with AKT1 (By similarity). Isoform 1 and isoform 2 interact with RNF20. Isoform 2 interacts with HUWE1. Interacts with DNAJC21 (PubMed:27346687).

    Three dimensional structures from OCA and Proteopedia for PA2G4 Gene

    Alternative splice isoforms for PA2G4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PA2G4 Gene

Post-translational modifications for PA2G4 Gene

  • In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.
  • Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.
  • Ubiquitination at Lys158, Lys172, Lys253, isoforms=2344, and Lys376
  • Modification sites at PhosphoSitePlus

Other Protein References for PA2G4 Gene

No data available for DME Specific Peptides for PA2G4 Gene

Domains & Families for PA2G4 Gene

Gene Families for PA2G4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PA2G4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ80

UniProtKB/Swiss-Prot:

PA2G4_HUMAN :
  • Belongs to the peptidase M24 family.
Family:
  • Belongs to the peptidase M24 family.
genes like me logo Genes that share domains with PA2G4: view

Function for PA2G4 Gene

Molecular function for PA2G4 Gene

GENATLAS Biochemistry:
murine cell-cycle P38-2G4 homolog,confined to the nucleus during interphase and cytoplasmic from metaphase through to telophase,widely expressed
UniProtKB/Swiss-Prot Function:
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Phenotypes From GWAS Catalog for PA2G4 Gene

Gene Ontology (GO) - Molecular Function for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15073182
GO:0003700 DNA binding transcription factor activity IDA 15073182
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 11268000
GO:0031625 ubiquitin protein ligase binding IPI 19037095
genes like me logo Genes that share ontologies with PA2G4: view
genes like me logo Genes that share phenotypes with PA2G4: view

Animal Models for PA2G4 Gene

MGI Knock Outs for PA2G4:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PA2G4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PA2G4 Gene

Localization for PA2G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PA2G4 Gene

Isoform 1: Cytoplasm. Nucleus, nucleolus. Note=Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269 PubMed:16832058}.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PA2G4 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 15073182
GO:0005730 nucleolus IEA,IDA 16832058
GO:0005737 cytoplasm IEA,IDA 16832058
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with PA2G4: view

Pathways & Interactions for PA2G4 Gene

genes like me logo Genes that share pathways with PA2G4: view

Pathways by source for PA2G4 Gene

1 BioSystems pathway for PA2G4 Gene
3 Reactome pathways for PA2G4 Gene

SIGNOR curated interactions for PA2G4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing IEA --
GO:0006417 regulation of translation IEA --
GO:0007050 cell cycle arrest TAS 7556453
genes like me logo Genes that share ontologies with PA2G4: view

Drugs & Compounds for PA2G4 Gene

(1) Drugs for PA2G4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PA2G4: view

Transcripts for PA2G4 Gene

Unigene Clusters for PA2G4 Gene

Proliferation-associated 2G4, 38kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PA2G4

Alternative Splicing Database (ASD) splice patterns (SP) for PA2G4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for PA2G4 Gene

GeneLoc Exon Structure for
PA2G4
ECgene alternative splicing isoforms for
PA2G4

Expression for PA2G4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PA2G4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PA2G4 Gene



Protein tissue co-expression partners for PA2G4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PA2G4 Gene:

PA2G4

SOURCE GeneReport for Unigene cluster for PA2G4 Gene:

Hs.524498

mRNA Expression by UniProt/SwissProt for PA2G4 Gene:

Q9UQ80-PA2G4_HUMAN
Tissue specificity: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.

Evidence on tissue expression from TISSUES for PA2G4 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Skin(4.8)
  • Liver(4.7)
  • Eye(3.3)
  • Intestine(2.8)
  • Muscle(2.5)
  • Kidney(2.4)
  • Heart(2.3)
  • Stomach(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PA2G4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PA2G4 Gene

Orthologs for PA2G4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PA2G4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
PA2G4 33
  • 96.53 (n)
chimpanzee
(Pan troglodytes)
Mammalia PA2G4 33
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PA2G4 33 34
  • 95.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pa2g4 33 16 34
  • 92.13 (n)
rat
(Rattus norvegicus)
Mammalia Pa2g4 33
  • 91.88 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 94 (a)
OneToMany
PA2G4 33
  • 81.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pa2g4 33
  • 78.95 (n)
Str.671 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8907 33
zebrafish
(Danio rerio)
Actinopterygii pa2g4b 34
  • 83 (a)
ManyToMany
pa2g4a 33 34
  • 76.96 (n)
wufb37h04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9574 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005108 33
  • 58.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10576 35 33 34
  • 58.26 (n)
worm
(Caenorhabditis elegans)
Secernentea W08E12.7 35 33 34
  • 54.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP2 34
  • 18 (a)
OneToMany
ARX1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG2 33
  • 58.14 (n)
rice
(Oryza sativa)
Liliopsida Os05g0350500 33
  • 57.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6876 34
  • 56 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdb4 33
  • 49.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00422 33
  • 46.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10766 33
Species where no ortholog for PA2G4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PA2G4 Gene

ENSEMBL:
Gene Tree for PA2G4 (if available)
TreeFam:
Gene Tree for PA2G4 (if available)

Paralogs for PA2G4 Gene

Paralogs for PA2G4 Gene

(1) SIMAP similar genes for PA2G4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PA2G4: view

Variants for PA2G4 Gene

Sequence variations from dbSNP and Humsavar for PA2G4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000153578 -- 56,112,008(+) G/A intron_variant
rs1000436264 -- 56,112,633(+) ATAGTCCCAGCTACC/ intron_variant
rs1000449914 -- 56,105,238(+) G/T intron_variant
rs1000454579 -- 56,111,881(+) G/T intron_variant
rs1000760175 -- 56,106,006(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PA2G4 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832427 CNV loss 17160897
nsv973075 CNV duplication 23825009

Variation tolerance for PA2G4 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PA2G4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PA2G4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PA2G4 Gene

Disorders for PA2G4 Gene

Additional Disease Information for PA2G4

No disorders were found for PA2G4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PA2G4 Gene

Publications for PA2G4 Gene

  1. Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4. (PMID: 9345902) Lamartine J … Sylla BS (Cytogenetics and cell genetics 1997) 2 3 4 22 58
  2. The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. (PMID: 17765895) Kowalinski E … Sinning I (FEBS letters 2007) 3 4 22 58
  3. Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling. (PMID: 15583694) Zhang Y … Hamburger AW (British journal of cancer 2005) 3 4 22 58
  4. Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases. (PMID: 12682367) Zhang Y … Hamburger AW (Nucleic acids research 2003) 3 4 22 58
  5. Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. (PMID: 11268000) Xia X … Hamburger AW (Journal of cellular physiology 2001) 3 4 22 58

Products for PA2G4 Gene

  • Addgene plasmids for PA2G4

Sources for PA2G4 Gene

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