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Aliases for P2RY8 Gene

Aliases for P2RY8 Gene

  • P2Y Receptor Family Member 8 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 8 2 3
  • Purinergic Receptor P2Y8 2 3
  • P2Y Purinoceptor 8 3 4
  • P2Y8 3 4
  • G-Protein Coupled Purinergic Receptor P2Y8 3

External Ids for P2RY8 Gene

Previous GeneCards Identifiers for P2RY8 Gene

  • GC00U990860
  • GC0XM001162
  • GC0XM001226
  • GC0YM001625
  • GC0XM001625

Summaries for P2RY8 Gene

Entrez Gene Summary for P2RY8 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY8 Gene

P2RY8 (P2Y Receptor Family Member 8) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for P2RY8 Gene

Tocris Summary for P2RY8 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY8 Gene

Additional gene information for P2RY8 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY8 Gene

Genomics for P2RY8 Gene

GeneHancer (GH) Regulatory Elements for P2RY8 Gene

Promoters and enhancers for P2RY8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ001535 Promoter/Enhancer 1.9 EPDnew Ensembl dbSUPER 600.7 +1.5 1505 4 SP1 ELF3 NKRF CEBPG ZNF687 MAFK CREM MLLT1 ZNF384 RAD21 P2RY8 AKAP17A ASMTL
GH0XJ001493 Promoter/Enhancer 1.7 EPDnew Ensembl dbSUPER 600.3 +43.6 43594 1 ZNF687 RELA MLLT1 ZBED1 IKZF1 POLR2A BACH1 IKZF2 LARP7 TRIM22 P2RY8 ASMTL
GH0XJ001591 Promoter 1.8 EPDnew Ensembl 12.3 -54.9 -54895 2.4 ZNF652 SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A ZNF687 ELF1 AKAP17A P2RY8 ASMT
GH0XJ001471 Enhancer 0.9 FANTOM5 dbSUPER 22.6 +65.3 65336 0.2 SP1 ZNF687 CREM IKZF1 BACH1 TRIM22 IKZF2 CBFB DPF2 EED P2RY8 AKAP17A ASMTL ASMT CSF2RA
GH0XJ001491 Enhancer 1 FANTOM5 dbSUPER 16.2 +45.4 45358 0.3 SP1 NKRF ZNF24 SP5 IKZF1 POLR2A ZBTB33 PKNOX1 RFX1 ZNF143 P2RY8 ASMTL AKAP17A ASMT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY8 gene promoter:
  • CREB
  • deltaCREB
  • POU3F1

Genomic Locations for P2RY8 Gene

Genomic Locations for P2RY8 Gene
74,935 bases
Minus strand
74,573 bases
Minus strand

Genomic View for P2RY8 Gene

Genes around P2RY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY8 Gene

Proteins for P2RY8 Gene

  • Protein details for P2RY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2Y purinoceptor 8
    Protein Accession:

    Protein attributes for P2RY8 Gene

    359 amino acids
    Molecular mass:
    40635 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for P2RY8 Gene

Post-translational modifications for P2RY8 Gene

  • Glycosylation at isoforms=11 and posLast=55
  • Ubiquitination at posLast=132132
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY8 Gene

Domains & Families for P2RY8 Gene

Gene Families for P2RY8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for P2RY8 Gene

Suggested Antigen Peptide Sequences for P2RY8 Gene

GenScript: Design optimal peptide antigens:
  • P2Y purinoceptor 8 (P2RY8_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY8: view

Function for P2RY8 Gene

Molecular function for P2RY8 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor for purines coupled to G-proteins.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic regulation.

Gene Ontology (GO) - Molecular Function for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY8: view
genes like me logo Genes that share phenotypes with P2RY8: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for P2RY8 - Now 50% OFF >
  • * P2RY8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * P2RY8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for P2RY8

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for P2RY8 Gene

Localization for P2RY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY8 Gene

Pathways & Interactions for P2RY8 Gene

PathCards logo

SuperPathways for P2RY8 Gene

genes like me logo Genes that share pathways with P2RY8: view

Pathways by source for P2RY8 Gene

1 KEGG pathway for P2RY8 Gene

Gene Ontology (GO) - Biological Process for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA 21873635
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with P2RY8: view

No data available for SIGNOR curated interactions for P2RY8 Gene

Drugs & Compounds for P2RY8 Gene

(6) Drugs for P2RY8 Gene - From: DGIdb and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0
2-Methylthioadenosine diphosphate trisodium salt Pharma Potent agonist for P2Y1, P2Y12 and P2Y13 0
MRS 2365 Pharma Highly potent and selective P2Y1 agonist 0
MRS 2690 Pharma Potent P2Y14 agonist 0
MRS 2693 trisodium salt Pharma Selective P2Y6 agonist 0

(5) Tocris Compounds for P2RY8 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY8: view

Transcripts for P2RY8 Gene

mRNA/cDNA for P2RY8 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for P2RY8 Gene

Purinergic receptor P2Y, G-protein coupled, 8:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for P2RY8 - Now 50% OFF >
  • * P2RY8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * P2RY8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for P2RY8

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY8 Gene

No ASD Table

Relevant External Links for P2RY8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RY8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY8 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY8 Gene

This gene is overexpressed in Whole Blood (x12.5) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for P2RY8 Gene

This gene is overexpressed in Monocytes (27.4), CD8 Tcells (15.2), CD4 Tcells (12.3), and Blymphocyte (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY8 Gene

Protein tissue co-expression partners for P2RY8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RY8 Gene:


SOURCE GeneReport for Unigene cluster for P2RY8 Gene:


mRNA Expression by UniProt/SwissProt for P2RY8 Gene:

Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
genes like me logo Genes that share expression patterns with P2RY8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY8 Gene

Orthologs for P2RY8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia P2RY8 35 34
  • 99.26 (n)
(Bos Taurus)
Mammalia P2RY8 35 34
  • 82.57 (n)
(Canis familiaris)
Mammalia LOC100856663 34
  • 81.22 (n)
P2RY8 35
  • 78 (a)
(Monodelphis domestica)
Mammalia P2RY8 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia P2RY8 35
  • 62 (a)
(Gallus gallus)
Aves P2RY8 35 34
  • 61.7 (n)
(Anolis carolinensis)
Reptilia P2RY8 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487194 34
  • 52.94 (n)
(Danio rerio)
Actinopterygii LOC566497 34
  • 58.1 (n)
p2ry8 35
  • 50 (a)
Species where no ortholog for P2RY8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY8 Gene

Gene Tree for P2RY8 (if available)
Gene Tree for P2RY8 (if available)
Evolutionary constrained regions (ECRs) for P2RY8: view image

Paralogs for P2RY8 Gene

(18) SIMAP similar genes for P2RY8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY8: view

Variants for P2RY8 Gene

Sequence variations from dbSNP and Humsavar for P2RY8 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs10563406 -- 1,535,727(-) AGA/A genic_upstream_transcript_variant, intron_variant
rs10657765 -- 1,504,316(-) AAAAAAAAAAAAA/AAAAAAAAAAAA/AAAAAAAAAAAAAA/AAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAA genic_upstream_transcript_variant, intron_variant
rs10700341 -- 1,497,640(-) /AA genic_upstream_transcript_variant, intron_variant
rs10715183 -- 1,480,297(-) TTTTTTTTTTTT/TTTTTTTTTT/TTTTTTTTTTT/TTTTTTTTTTTTT genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY8 Gene

Variant ID Type Subtype PubMed ID
dgv1303e201 CNV deletion 23290073
dgv1304e201 CNV deletion 23290073
esv2294449 CNV deletion 18987734
esv2660373 CNV deletion 23128226
esv2662997 CNV deletion 23128226
esv2665018 CNV deletion 23128226
esv2667421 CNV deletion 23128226
esv2674649 CNV deletion 23128226
esv2676182 CNV deletion 23128226
esv2739721 CNV deletion 23290073
esv2739722 CNV deletion 23290073
esv2739724 CNV deletion 23290073
esv2739726 CNV deletion 23290073
esv2739727 CNV deletion 23290073
esv2739728 CNV deletion 23290073
esv2739731 CNV deletion 23290073
esv29996 CNV loss 17803354
esv3558487 CNV deletion 23714750
esv3558489 CNV deletion 23714750
nsv1077214 CNV deletion 25765185
nsv1115920 CNV duplication 24896259
nsv1119381 CNV duplication 24896259
nsv1132747 CNV duplication 24896259
nsv1132748 CNV duplication 24896259
nsv1141659 CNV duplication 24896259
nsv1141660 CNV duplication 24896259
nsv1146517 CNV duplication 26484159
nsv1151816 CNV duplication 26484159
nsv1151885 CNV duplication 26484159
nsv1153109 CNV duplication 26484159
nsv510811 CNV deletion 20534489

Variation tolerance for P2RY8 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY8 Gene

Disorders for P2RY8 Gene

Additional Disease Information for P2RY8

No disorders were found for P2RY8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY8 Gene

Publications for P2RY8 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K … Ogilvie A (Biochimica et biophysica acta 2000) 2 3 4 58
  2. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PMID: 17487742) Fujiwara S … Mano H (Leukemia & lymphoma 2007) 3 23 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. (PMID: 15466006) Cantagrel V … Villard L (Journal of medical genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for P2RY8 Gene

Sources for P2RY8 Gene

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