The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, whi... See more...

Aliases for P2RY6 Gene

Aliases for P2RY6 Gene

  • Pyrimidinergic Receptor P2Y6 2 3 5
  • P2Y6 2 3 4
  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 2 3
  • P2Y Purinoceptor 6 3 4
  • G-Coupled Nucleotide Receptor 3
  • P2 Purinoceptor 3
  • P2Y6 Receptor 3
  • P2RY6 5

External Ids for P2RY6 Gene

Previous GeneCards Identifiers for P2RY6 Gene

  • GC11P075241
  • GC11P074515
  • GC11P073198
  • GC11P072701
  • GC11P072653
  • GC11P072975
  • GC11P069270

Summaries for P2RY6 Gene

Entrez Gene Summary for P2RY6 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY6 Gene

P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot Summary for P2RY6 Gene

  • Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for P2RY6 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY6 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RY6 Gene

Genomics for P2RY6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for P2RY6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J073268 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 257.4 +7.5 7549 7.7 JUND CEBPA FOXA1 NR2C1 ZNF217 SIN3A ELF1 FOXA2 CTBP1 MAFF P2RY6 RELT FCHSD2 ENSG00000215841 P2RY2 ARHGEF17 HSALNG0085624
GH11J073264 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 250.7 +0.2 203 1 SIN3A ZSCAN29 ZKSCAN1 P2RY6 ARHGEF17 HSALNG0085624
GH11J073307 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +52.8 52813 21.9 BCLAF1 SP1 ZNF207 MYC ZNF600 ZNF654 IKZF1 ZMYM3 CEBPA POLR2A ARHGEF17 RELT P2RY6 FAM168A PAAF1 piR-43105-092 piR-33826 ARHGEF17-AS1 NONHSAG009017.2 HSALNG0085624
GH11J073287 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.5 +24.2 24196 3.1 BCLAF1 ZNF207 IKZF1 ZNF654 ZNF600 ZMYM3 NFIC ZIC2 ZBTB10 MXD4 P2RY6 ARHGEF17-AS1 ARAP1 ARAP1-AS2 RPS12P20 ARHGEF17 HSALNG0085624
GH11J073242 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 12.3 -21.8 -21782 1.3 SP1 ZNF207 ZNF654 IKZF1 ZNF600 POLR2A ZIC2 CTCF REST DEK P2RY6 ENSG00000260401 HSALNG0085616-003 lnc-P2RY2-11 P2RY2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY6

Top Transcription factor binding sites by QIAGEN in the P2RY6 gene promoter:
  • E47
  • Egr-2
  • Hand1
  • Spz1

Genomic Locations for P2RY6 Gene

Latest Assembly
chr11:73,264,498-73,305,103
(GRCh38/hg38)
Size:
40,606 bases
Orientation:
Plus strand

Previous Assembly
chr11:72,975,551-73,009,670
(GRCh37/hg19 by Entrez Gene)
Size:
34,120 bases
Orientation:
Plus strand

chr11:72,975,550-73,009,662
(GRCh37/hg19 by Ensembl)
Size:
34,113 bases
Orientation:
Plus strand

Genomic View for P2RY6 Gene

Genes around P2RY6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY6 Gene

Proteins for P2RY6 Gene

  • Protein details for P2RY6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15077-P2RY6_HUMAN
    Recommended name:
    P2Y purinoceptor 6
    Protein Accession:
    Q15077
    Secondary Accessions:
    • Q15754

    Protein attributes for P2RY6 Gene

    Size:
    328 amino acids
    Molecular mass:
    36429 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY6 Gene

neXtProt entry for P2RY6 Gene

Post-translational modifications for P2RY6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY6 Gene

Domains & Families for P2RY6 Gene

Gene Families for P2RY6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY6 Gene

InterPro:
Blocks:
  • P2Y6 purinoceptor signature
  • P2 purinoceptor signature

Suggested Antigen Peptide Sequences for P2RY6 Gene

GenScript: Design optimal peptide antigens:
  • P2Y purinoceptor 6 (P2RY6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15077

UniProtKB/Swiss-Prot:

P2RY6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY6: view

Function for P2RY6 Gene

Molecular function for P2RY6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GENATLAS Biochemistry:
purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell lines,predominantly responding to ATP,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for P2RY6 Gene

Gene Ontology (GO) - Molecular Function for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001621 ADP receptor activity IDA 8670200
GO:0004930 G protein-coupled receptor activity IEA,TAS 8670200
GO:0005515 protein binding IPI 25416956
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IEA --
GO:0045029 UDP-activated nucleotide receptor activity IDA 8670200
genes like me logo Genes that share ontologies with P2RY6: view
genes like me logo Genes that share phenotypes with P2RY6: view

Animal Models for P2RY6 Gene

MGI Knock Outs for P2RY6:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY6

Clone products for research

  • Addgene plasmids for P2RY6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY6 Gene

Localization for P2RY6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY6 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8670200
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA --
genes like me logo Genes that share ontologies with P2RY6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY6 Gene

Pathways & Interactions for P2RY6 Gene

genes like me logo Genes that share pathways with P2RY6: view

Pathways by source for P2RY6 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY6 Gene
  • Signal transduction IP3 signaling
1 Qiagen pathway for P2RY6 Gene
  • P2Y Receptor Signaling

SIGNOR curated interactions for P2RY6 Gene

Gene Ontology (GO) - Biological Process for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IMP,ISS --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IC 8670200
GO:0007202 activation of phospholipase C activity TAS 17410128
genes like me logo Genes that share ontologies with P2RY6: view

Drugs & Compounds for P2RY6 Gene

(44) Drugs for P2RY6 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prasugrel Approved Pharma ADP receptor inhibitor 0
Uridine triphosphate Experimental, Investigational Pharma 0
MC-1 Investigational Pharma 0
MRS 2365 Pharma Highly potent and selective P2Y1 agonist 0
MRS 2690 Pharma Potent P2Y14 agonist 0

(15) Additional Compounds for P2RY6 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Partial agonist 58-64-0
5-iodoUDP
Agonist, Full agonist
UDP
Agonist, Full agonist
UTP
Agonist, Partial agonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8

(5) Tocris Compounds for P2RY6 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3

(20) ApexBio Compounds for P2RY6 Gene

Compound Action Cas Number
2-ThioUTP tetrasodium salt 1343364-70-4
5-OMe-UDP trisodium salt Potent P2Y6 agonist 1207530-98-0
DMNPE-caged ATP diammonium salt
MRS 2179 tetrasodium salt 1454889-37-2
MRS 2211
MRS 2279 367909-40-8
MRS 2365 436847-09-5
MRS 2500 tetraammonium salt 630103-23-0
MRS 2578 P2Y6 receptor antagonist,potent and selective 711019-86-2
MRS 2690 15039-58-4
MRS 2693 trisodium salt 1448858-83-0
MRS 2768 tetrasodium salt 1047980-83-5
MRS 2957 triethylammonium salt 1228271-30-4
NF 340 202982-98-7
NF 546 1006028-37-0
PIT 56583-49-4
Prasugrel ADP receptor inhibitor 150322-43-3
PSB 0474 917567-60-3
UDP disodium salt 27821-45-0
UTPγS trisodium salt 1266569-94-1
genes like me logo Genes that share compounds with P2RY6: view

Drug products for research

Transcripts for P2RY6 Gene

mRNA/cDNA for P2RY6 Gene

9 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY6

Clone products for research

  • Addgene plasmids for P2RY6

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: -

Relevant External Links for P2RY6 Gene

GeneLoc Exon Structure for
P2RY6

Expression for P2RY6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY6 Gene

This gene is overexpressed in Spleen (x15.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RY6

SOURCE GeneReport for Unigene cluster for P2RY6 Gene:

Hs.16362

Evidence on tissue expression from TISSUES for P2RY6 Gene

  • Nervous system(4.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with P2RY6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY6 Gene

Orthologs for P2RY6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia P2RY6 29 30
  • 99.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia P2RY6 29 30
  • 89.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia P2RY6 29 30
  • 88.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia P2ry6 29
  • 84.56 (n)
Mouse
(Mus musculus)
Mammalia P2ry6 29 16 30
  • 84.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia P2RY6 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves P2RY6 29
  • 70.2 (n)
P2RY3 30
  • 62 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia P2RY6 30
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC566099 29
  • 60.85 (n)
P2RY6 30
  • 58 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7925 29
Species where no ortholog for P2RY6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for P2RY6 Gene

ENSEMBL:
Gene Tree for P2RY6 (if available)
TreeFam:
Gene Tree for P2RY6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY6: view image
Alliance of Genome Resources:
Additional Orthologs for P2RY6

Paralogs for P2RY6 Gene

(23) SIMAP similar genes for P2RY6 Gene using alignment to 4 proteins:

  • P2RY6_HUMAN
  • F5GX90_HUMAN
  • F5GYF3_HUMAN
  • F5H7H9_HUMAN
genes like me logo Genes that share paralogs with P2RY6: view

Variants for P2RY6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RY6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1894075 Benign: not provided 73,272,314(+) G/A
NM_001277208.1(P2RY6):c.117G>A (p.Ser39=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs60848410 Benign: not provided 73,297,304(+) C/T
NM_001277208.1(P2RY6):c.1089C>T (p.Tyr363=)
SYNONYMOUS
rs61741436 Benign: not provided 73,297,344(+) T/C
NM_001277208.1(P2RY6):c.1129T>C (p.Leu377=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for P2RY6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for P2RY6 Gene

Variant ID Type Subtype PubMed ID
nsv387 CNV insertion 18451855
nsv520665 CNV loss 19592680
nsv832208 CNV gain 17160897

Variation tolerance for P2RY6 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY6
Leiden Open Variation Database (LOVD)
P2RY6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY6 Gene

Disorders for P2RY6 Gene

Additional Disease Information for P2RY6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for P2RY6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY6 Gene

Publications for P2RY6 Gene

  1. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PMID: 8670200) Communi D … Boeynaems JM (Biochemical and biophysical research communications 1996) 2 3 4 22
  2. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PMID: 9412455) Maier R … Bilbe G (Biochemical and biophysical research communications 1997) 3 4 22
  3. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PMID: 9268704) Maier R … Bilbe G (Biochemical and biophysical research communications 1997) 3 4 22
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PMID: 19124756) Jiang Y … Boyce JA (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 22

Products for P2RY6 Gene

Sources for P2RY6 Gene