Aliases for P2RY4 Gene
External Ids for P2RY4 Gene
Previous GeneCards Identifiers for P2RY4 Gene
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
GeneCards Summary for P2RY4 Gene
P2RY4 (Pyrimidinergic Receptor P2Y4) is a Protein Coding gene. Diseases associated with P2RY4 include Infiltrative Basal Cell Carcinoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and uridine nucleotide receptor activity. An important paralog of this gene is P2RY2.
UniProtKB/Swiss-Prot Summary for P2RY4 Gene
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.