The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008] See more...

Aliases for P2RY4 Gene

Aliases for P2RY4 Gene

  • Pyrimidinergic Receptor P2Y4 2 3 5
  • P2Y4 2 3 4
  • NRU 2 3 4
  • P2P 2 3 4
  • UNR 2 3 4
  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4 2 3
  • Uridine Nucleotide Receptor 3 4
  • P2Y Purinoceptor 4 3 4
  • P2RY4 5

External Ids for P2RY4 Gene

Previous GeneCards Identifiers for P2RY4 Gene

  • GC0XM065656
  • GC0XM066955
  • GC0XM067711
  • GC0XM068345
  • GC0XM069261
  • GC0XM069394
  • GC0XM069478
  • GC0XM063299

Summaries for P2RY4 Gene

Entrez Gene Summary for P2RY4 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY4 Gene

P2RY4 (Pyrimidinergic Receptor P2Y4) is a Protein Coding gene. Diseases associated with P2RY4 include Infiltrative Basal Cell Carcinoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and uridine nucleotide receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot Summary for P2RY4 Gene

  • Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Tocris Summary for P2RY4 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RY4 Gene

Genomics for P2RY4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for P2RY4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ071213 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 15.5 -955.7 -955712 4.2 ZMYM3 CEBPA YY1 MXD4 ZFP64 HOMEZ KMT2B FOXA2 SMAD4 RXRA GJB1 NONO TAF1 OGT MED12 P2RY4 ENSG00000229601 PABPN1P1 ARR3 RHOG2P
GH0XJ071250 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -993.6 -993583 6.1 SP1 ZNF207 IKZF1 MYC ZNF580 ZSCAN16 BRCA1 NFIC POLR2A ZIC2 NONO ZMYM3 LOC105373247 lnc-IL2RG-3 MED12 OGT TAF1 PABPN1P1 ERCC6L ARR3
GH0XJ071181 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -923.0 -922963 4.1 SP1 ZNF654 IKZF1 MYC JUND ZNF580 ZNF592 ATF2 POLR2A CEBPA lnc-IL2RG-5 lnc-NLGN3-2 TAF1 NONO OGT MED12 PABPN1P1 ENSG00000229601 RPS23P8 ZMYM3
GH0XJ071144 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -886.0 -885972 3.3 MYC NCOR1 IKZF1 POLR2A ZBTB10 MNT KLF7 ZNF148 MCM3 ARNT NLGN3 MED12 TAF1 NONO PABPN1P1 RHOG2P ARR3 P2RY4 OGT RPS23P8
GH0XJ070253 Enhancer 0.8 Ensembl ENCODE 0.4 +6.1 6073 2.3 FOXA2 RARA FOSL2 JUND CREM BCL6 NR2F6 JUN ATF3 GATAD2A HSALNG0138420 HSALNG0138421 RNA5SP507 P2RY4 AWAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY4

Top Transcription factor binding sites by QIAGEN in the P2RY4 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ARP-1
  • E47
  • Hand1
  • ITF-2
  • Tal-1beta

Genomic Locations for P2RY4 Gene

Latest Assembly
chrX:70,258,166-70,260,204
(GRCh38/hg38)
Size:
2,039 bases
Orientation:
Minus strand

Previous Assembly
chrX:69,478,016-69,480,054
(GRCh37/hg19 by Entrez Gene)
Size:
2,039 bases
Orientation:
Minus strand

chrX:69,478,016-69,479,654
(GRCh37/hg19 by Ensembl)
Size:
1,639 bases
Orientation:
Minus strand

Genomic View for P2RY4 Gene

Genes around P2RY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY4 Gene

Proteins for P2RY4 Gene

  • Protein details for P2RY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51582-P2RY4_HUMAN
    Recommended name:
    P2Y purinoceptor 4
    Protein Accession:
    P51582
    Secondary Accessions:
    • Q4VBB7
    • Q4VBB8
    • Q502W2
    • Q5JT22

    Protein attributes for P2RY4 Gene

    Size:
    365 amino acids
    Molecular mass:
    40963 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY4 Gene

neXtProt entry for P2RY4 Gene

Post-translational modifications for P2RY4 Gene

  • Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for P2RY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY4 Gene

Domains & Families for P2RY4 Gene

Gene Families for P2RY4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY4 Gene

InterPro:
Blocks:
  • P2 purinoceptor signature
  • P2Y4 purinoceptor signature

Suggested Antigen Peptide Sequences for P2RY4 Gene

GenScript: Design optimal peptide antigens:
  • Pyrimidinergic receptor P2Y4 (C6G7W3_HUMAN)
  • Pyrimidinergic receptor P2Y4 (C6G7W4_HUMAN)
  • Uridine nucleotide receptor (P2RY4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51582

UniProtKB/Swiss-Prot:

P2RY4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY4: view

Function for P2RY4 Gene

Molecular function for P2RY4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
GENATLAS Biochemistry:
purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 32814053
GO:0005524 ATP binding IEA --
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IEA --
GO:0045030 UTP-activated nucleotide receptor activity TAS 8537335
genes like me logo Genes that share ontologies with P2RY4: view
genes like me logo Genes that share phenotypes with P2RY4: view

Animal Models for P2RY4 Gene

MGI Knock Outs for P2RY4:

Animal Models for research

  • Taconic Biosciences Mouse Models for P2RY4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY4 Gene

Localization for P2RY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8537336
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY4 Gene

Pathways & Interactions for P2RY4 Gene

genes like me logo Genes that share pathways with P2RY4: view

Pathways by source for P2RY4 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY4 Gene
  • Signal transduction IP3 signaling
1 Qiagen pathway for P2RY4 Gene
  • P2Y Receptor Signaling

SIGNOR curated interactions for P2RY4 Gene

Gene Ontology (GO) - Biological Process for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway TAS 8537336
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8537335
GO:0030321 transepithelial chloride transport IEA --
genes like me logo Genes that share ontologies with P2RY4: view

Drugs & Compounds for P2RY4 Gene

(27) Drugs for P2RY4 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Promethazine Approved, Investigational Pharma Target, inhibitor 494
Diquafosol Experimental Pharma agonist 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Antagonist 0

(16) Additional Compounds for P2RY4 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gtp
Agonist, Partial agonist
N<sup>4</sup>-phenylethoxycytidine-5?à?-triphosphate
Agonist, Full agonist
Up<sub>4</sub>dC
Agonist, Full agonist
Up<sub>4</sub>U
Agonist, Full agonist
UTP
Agonist, Full agonist

(5) Tocris Compounds for P2RY4 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY4: view

Transcripts for P2RY4 Gene

mRNA/cDNA for P2RY4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY4

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY4 Gene

No ASD Table

Relevant External Links for P2RY4 Gene

GeneLoc Exon Structure for
P2RY4

Expression for P2RY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY4 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RY4

SOURCE GeneReport for Unigene cluster for P2RY4 Gene:

Hs.673854

mRNA Expression by UniProt/SwissProt for P2RY4 Gene:

P51582-P2RY4_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for P2RY4 Gene

  • Pancreas(4.4)
  • Nervous system(2.4)
  • Lung(2.2)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with P2RY4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY4 Gene

Orthologs for P2RY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia P2RY4 29 30
  • 98.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia P2RY4 29 30
  • 85.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia P2RY4 29
  • 84.67 (n)
-- 30
  • 39 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia P2ry4 29
  • 83.86 (n)
Mouse
(Mus musculus)
Mammalia P2ry4 29 16 30
  • 83.67 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia P2RY4 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100857687 29
  • 66.56 (n)
P2RY4 30
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia p2ry4 29
  • 60.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia p2ry4-prov 29
Zebrafish
(Danio rerio)
Actinopterygii pr2y4l 29 30
  • 61.64 (n)
OneToOne
Species where no ortholog for P2RY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for P2RY4 Gene

ENSEMBL:
Gene Tree for P2RY4 (if available)
TreeFam:
Gene Tree for P2RY4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY4: view image
Alliance of Genome Resources:
Additional Orthologs for P2RY4

Paralogs for P2RY4 Gene

(24) SIMAP similar genes for P2RY4 Gene using alignment to 3 proteins:

  • P2RY4_HUMAN
  • C6G7W3_HUMAN
  • C6G7W4_HUMAN
genes like me logo Genes that share paralogs with P2RY4: view

Variants for P2RY4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RY4 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs147991664 Benign: not provided 70,258,672(-) C/T
NM_002565.3(P2RY4):c.953G>A (p.Arg318His)
MISSENSE
rs201294501 Benign: not provided 70,259,585(-) G/A
NM_002565.3(P2RY4):c.40C>T (p.Leu14Phe)
MISSENSE
rs1152186 -- p.Val168Met
rs1152187 -- p.Asn178Thr
rs1152188 -- p.Pro191Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for P2RY4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for P2RY4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
nsv519108 CNV loss 19592680
nsv525258 CNV gain 19592680

Variation tolerance for P2RY4 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY4
Leiden Open Variation Database (LOVD)
P2RY4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY4 Gene

Disorders for P2RY4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY4 Gene - From: COP

Disorder Aliases PubMed IDs
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search P2RY4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for P2RY4

genes like me logo Genes that share disorders with P2RY4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY4 Gene

Publications for P2RY4 Gene

  1. Cloning and functional expression of a human uridine nucleotide receptor. (PMID: 8537336) Communi D … Boeynaems JM (The Journal of biological chemistry 1995) 2 3 4 22
  2. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PMID: 11114308) Brinson AE … Harden TK (The Journal of biological chemistry 2001) 3 4 22
  3. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (PMID: 8537335) Nguyen T … O'Dowd BF (The Journal of biological chemistry 1995) 3 4 22
  4. ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells. (PMID: 19900397) Scodelaro Bilbao P … Santillán G (Archives of biochemistry and biophysics 2010) 3 22
  5. Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. (PMID: 19836435) Buzzi N … de Boland AR (Biochimica et biophysica acta 2009) 3 22

Products for P2RY4 Gene

Sources for P2RY4 Gene