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Aliases for P2RY2 Gene

Aliases for P2RY2 Gene

  • Purinergic Receptor P2Y2 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 2 2 3
  • P2U Purinoceptor 1 3 4
  • P2U Receptor 1 3 4
  • ATP Receptor 3 4
  • P2RU1 3 4
  • P2U1 3 4
  • P2Y2 3 4
  • P2U Nucleotide Receptor 3
  • Purinergic Receptor 4
  • P2Y Purinoceptor 2 3
  • Purinoceptor P2Y2 3
  • P2Y2R 3
  • HP2U 3
  • P2UR 3
  • P2U 3

External Ids for P2RY2 Gene

Previous GeneCards Identifiers for P2RY2 Gene

  • GC11P075255
  • GC11P074469
  • GC11P073152
  • GC11P072655
  • GC11P072606
  • GC11P072929
  • GC11P069224

Summaries for P2RY2 Gene

Entrez Gene Summary for P2RY2 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY2 Gene

P2RY2 (Purinergic Receptor P2Y2) is a Protein Coding gene. Diseases associated with P2RY2 include Dry Eye Syndrome and Lacrimal Apparatus Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot for P2RY2 Gene

  • Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Tocris Summary for P2RY2 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY2 Gene

Additional gene information for P2RY2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY2 Gene

Genomics for P2RY2 Gene

GeneHancer (GH) Regulatory Elements for P2RY2 Gene

Promoters and enhancers for P2RY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J073213 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.1 -106 5.7 PKNOX1 CLOCK ARID4B SIN3A ZBTB7B IRF4 ZNF48 GLIS2 RUNX3 SP3 ENSG00000215841 P2RY2 FCHSD2
GH11J073199 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 650.4 -15.0 -15028 3.2 KLF1 USF1 TAL1 MAX BACH1 TCF12 CTBP1 GATA3 PRDM10 RFX1 P2RY2 ENSG00000260401 ENSG00000215841 GC11M073182
GH11J073268 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +55.6 55599 7.7 FOXA2 ARID4B NEUROD1 SIN3A SCRT2 FOS RCOR1 IKZF2 SMARCA5 SMARCC1 P2RY6 RELT FCHSD2 P2RY2 ENSG00000215841 ARHGEF17
GH11J073192 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -21.9 -21945 4.7 PKNOX1 NFIB SREBF2 ZNF133 NEUROD1 SIN3A BATF ZBTB7B IRF4 RAD21 ENSG00000215841 P2RY2 ARHGEF17 RELT ENSG00000260401 GC11M073182
GH11J073187 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.5 -27.2 -27179 2.6 FOXA2 MAX EBF1 IRF4 GATA3 RERE POLR2A EED NR2F6 IKZF2 P2RY2 ENSG00000215841 ENSG00000260401 GC11M073182
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • c-Myb
  • AP-4
  • GATA-1

Genomic Locations for P2RY2 Gene

Genomic Locations for P2RY2 Gene
chr11:73,216,448-73,242,427
(GRCh38/hg38)
Size:
25,980 bases
Orientation:
Plus strand
chr11:72,929,343-72,947,397
(GRCh37/hg19)
Size:
18,055 bases
Orientation:
Plus strand

Genomic View for P2RY2 Gene

Genes around P2RY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY2 Gene

Proteins for P2RY2 Gene

  • Protein details for P2RY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41231-P2RY2_HUMAN
    Recommended name:
    P2Y purinoceptor 2
    Protein Accession:
    P41231
    Secondary Accessions:
    • B2R9W3
    • Q96EM8

    Protein attributes for P2RY2 Gene

    Size:
    377 amino acids
    Molecular mass:
    42273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY2 Gene

neXtProt entry for P2RY2 Gene

Post-translational modifications for P2RY2 Gene

  • Glycosylation at Asn13 and Asn9
  • Ubiquitination at isoforms=227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY2 Gene

Domains & Families for P2RY2 Gene

Gene Families for P2RY2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for P2RY2 Gene

Suggested Antigen Peptide Sequences for P2RY2 Gene

Graphical View of Domain Structure for InterPro Entry

P41231

UniProtKB/Swiss-Prot:

P2RY2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY2: view

Function for P2RY2 Gene

Molecular function for P2RY2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
GENATLAS Biochemistry:
purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for P2RY2 Gene

Gene Ontology (GO) - Molecular Function for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0038023 signaling receptor activity TAS 7779087
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY2: view
genes like me logo Genes that share phenotypes with P2RY2: view

Animal Models for P2RY2 Gene

MGI Knock Outs for P2RY2:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY2

CRISPR Products

Clone Products

  • Addgene plasmids for P2RY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY2 Gene

Localization for P2RY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8159738
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY2: view

Pathways & Interactions for P2RY2 Gene

genes like me logo Genes that share pathways with P2RY2: view

Gene Ontology (GO) - Biological Process for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006873 cellular ion homeostasis TAS 8159738
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS,IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY2: view

No data available for SIGNOR curated interactions for P2RY2 Gene

Drugs & Compounds for P2RY2 Gene

(56) Drugs for P2RY2 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved, Investigational Pharma Antagonist, Activator, antagonist, Target 18
calcium Approved Nutra 0
Prasugrel Approved Pharma ADP receptor inhibitor 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(23) Additional Compounds for P2RY2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Up<sub>4</sub>dC
Full agonist, Agonist
Up<sub>4</sub>U
Full agonist, Agonist
UTP
Full agonist, Agonist, Partial agonist
UTPgammaS
Full agonist, Agonist

(5) Tocris Compounds for P2RY2 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY2: view

Transcripts for P2RY2 Gene

mRNA/cDNA for P2RY2 Gene

Unigene Clusters for P2RY2 Gene

Purinergic receptor P2Y, G-protein coupled, 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for P2RY2

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: -

Relevant External Links for P2RY2 Gene

GeneLoc Exon Structure for
P2RY2
ECgene alternative splicing isoforms for
P2RY2

Expression for P2RY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY2 Gene

This gene is overexpressed in Muscle - Skeletal (x11.6), Esophagus - Mucosa (x7.6), and Vagina (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of P2RY2 Gene:

P2RY2

SOURCE GeneReport for Unigene cluster for P2RY2 Gene:

Hs.339

mRNA Expression by UniProt/SwissProt for P2RY2 Gene:

P41231-P2RY2_HUMAN
Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain.

Evidence on tissue expression from TISSUES for P2RY2 Gene

  • Lung(4.4)
  • Blood(4.3)
  • Kidney(4.3)
  • Muscle(2.7)
  • Heart(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with P2RY2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY2 Gene

Orthologs for P2RY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY2 34 33
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY2 33
  • 89.48 (n)
P2Y2 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY2 34 33
  • 89.1 (n)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry2 16 34 33
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia P2ry2 33
  • 85.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY2 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY2 34 33
  • 68.31 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry2 33
  • 64.36 (n)
MGC75941 33
zebrafish
(Danio rerio)
Actinopterygii P2RY2 (1 of 3) 34
  • 48 (a)
OneToMany
P2RY2 (3 of 3) 34
  • 45 (a)
OneToMany
P2RY2 (2 of 3) 34
  • 44 (a)
OneToMany
Species where no ortholog for P2RY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY2 Gene

ENSEMBL:
Gene Tree for P2RY2 (if available)
TreeFam:
Gene Tree for P2RY2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY2: view image

Paralogs for P2RY2 Gene

(18) SIMAP similar genes for P2RY2 Gene using alignment to 3 proteins:

  • P2RY2_HUMAN
  • C6G7W1_HUMAN
  • C6G7W2_HUMAN

Pseudogenes.org Pseudogenes for P2RY2 Gene

genes like me logo Genes that share paralogs with P2RY2: view

Variants for P2RY2 Gene

Sequence variations from dbSNP and Humsavar for P2RY2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000014606 -- 73,214,218(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000041476 -- 73,211,984(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000053902 -- 73,246,996(+) A/G/T downstream_transcript_variant
rs1000091054 -- 73,246,025(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000241729 -- 73,212,567(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY2 Gene

Variant ID Type Subtype PubMed ID
esv3429235 CNV insertion 20981092
esv3626812 CNV gain 21293372
esv3626813 CNV loss 21293372
nsv1038032 CNV gain 25217958
nsv476705 CNV novel sequence insertion 20440878
nsv518659 CNV gain 19592680
nsv832208 CNV gain 17160897

Variation tolerance for P2RY2 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY2 Gene

Human Gene Mutation Database (HGMD)
P2RY2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY2 Gene

Disorders for P2RY2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for P2RY2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
cystic fibrosis
  • cf
- elite association - COSMIC cancer census association via MalaCards
Search P2RY2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for P2RY2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with P2RY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY2 Gene

Publications for P2RY2 Gene

  1. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 8159738) Parr CE … Turner JT (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 58
  2. Purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene is associated with cerebral infarction in Japanese subjects. (PMID: 19763137) Wang Z … Hinohara S (Hypertension research : official journal of the Japanese Society of Hypertension 2009) 3 22 44 58
  3. Association of the purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene with myocardial infarction in Japanese men. (PMID: 19797825) Wang ZX … Hinohara S (Circulation journal : official journal of the Japanese Circulation Society 2009) 3 22 44 58
  4. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 7809171) Parr CE … Turner JT (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for P2RY2 Gene

Sources for P2RY2 Gene

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