Aliases for P2RY14 Gene
External Ids for P2RY14 Gene
Previous HGNC Symbols for P2RY14 Gene
Previous GeneCards Identifiers for P2RY14 Gene
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for P2RY14 Gene
P2RY14 (Purinergic Receptor P2Y14) is a Protein Coding gene. Diseases associated with P2RY14 include Orofacial Cleft 8 and Usher Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY12.
UniProtKB/Swiss-Prot Summary for P2RY14 Gene
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.