The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functio... See more...

Aliases for P2RY14 Gene

Aliases for P2RY14 Gene

  • Purinergic Receptor P2Y14 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 14 2 3
  • G-Protein Coupled Receptor 105 3 4
  • UDP-Glucose Receptor 3 4
  • P2Y Purinoceptor 14 3 4
  • GPR105 3 4
  • P2Y14 3 4
  • G Protein Coupled Receptor For UDP-Glucose 3
  • G Protein-Coupled Receptor 105 2
  • P2Y(14) Receptor 3
  • P2Y14 Receptor 3
  • KIAA0001 4
  • BPR105 3

External Ids for P2RY14 Gene

Previous HGNC Symbols for P2RY14 Gene

  • GPR105

Previous GeneCards Identifiers for P2RY14 Gene

  • GC03M152412
  • GC03M150929
  • GC03M148302

Summaries for P2RY14 Gene

Entrez Gene Summary for P2RY14 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY14 Gene

P2RY14 (Purinergic Receptor P2Y14) is a Protein Coding gene. Diseases associated with P2RY14 include Orofacial Cleft 8 and Usher Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY12.

UniProtKB/Swiss-Prot Summary for P2RY14 Gene

  • Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Tocris Summary for P2RY14 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY14 Gene

Additional gene information for P2RY14 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RY14 Gene

Genomics for P2RY14 Gene

GeneHancer (GH) Regulatory Elements for P2RY14 Gene

Promoters and enhancers for P2RY14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151274 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 509 +0.8 788 6.1 RELA SPI1 BATF MEIS2 JUNB CTCF ETV6 RUNX3 RELB SCRT2 P2RY14 GPR87 P2RY13 EIF2A lnc-AADACL2-6 MED12L
GH03J151224 Enhancer 1 FANTOM5 ENCODE 27 +51.4 51412 4.5 CTCF TCF12 FOS REST RAD21 SKI TRIM22 TBX3 SMC3 DEK P2RY14 P2RY12 RF00017-4142 GPR171 MED12L
GH03J151264 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +11.6 11627 4.8 EP300 RFX1 BCL11A TCF12 YY1 SPI1 IRF4 POU2F2 EBF1 BMI1 P2RY14 GPR87 SETP11 lnc-GPR87-1 MED12L
GH03J151303 Enhancer 1.1 ENCODE dbSUPER 17.6 -27.7 -27684 5.1 ZNF217 TCF12 JUND TEAD4 ZIC2 REST KLF4 RFX1 CUX1 CHD1 P2RY14 P2RY13 IGSF10 GPR87 ENSG00000286273 MED12L
GH03J151230 Enhancer 0.6 FANTOM5 ENCODE 32.1 +47.7 47713 1.1 ATF7 ETV6 P2RY14 MED12L P2RY13 RF00017-4142 GPR171
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY14

Top Transcription factor binding sites by QIAGEN in the P2RY14 gene promoter:
  • AML1a
  • C/EBPbeta
  • E2F
  • E2F-1
  • FOXD3
  • GR
  • POU3F1
  • RP58
  • SRF
  • SRF (504 AA)

Genomic Locations for P2RY14 Gene

Genomic Locations for P2RY14 Gene
chr3:151,212,115-151,278,628
(GRCh38/hg38)
Size:
66,514 bases
Orientation:
Minus strand
chr3:150,929,905-150,996,255
(GRCh37/hg19)
Size:
66,351 bases
Orientation:
Minus strand

Genomic View for P2RY14 Gene

Genes around P2RY14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY14 Gene

Proteins for P2RY14 Gene

  • Protein details for P2RY14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15391-P2Y14_HUMAN
    Recommended name:
    P2Y purinoceptor 14
    Protein Accession:
    Q15391
    Secondary Accessions:
    • Q8IYT7

    Protein attributes for P2RY14 Gene

    Size:
    338 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY14 Gene

neXtProt entry for P2RY14 Gene

Post-translational modifications for P2RY14 Gene

  • Glycosylation at Asn3 and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY14 Gene

No data available for DME Specific Peptides for P2RY14 Gene

Domains & Families for P2RY14 Gene

Gene Families for P2RY14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY14 Gene

Blocks:
  • UDP-glucose receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for P2RY14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75398, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA (A5JUU3_HUMAN)
  • UDP-glucose receptor (P2Y14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15391

UniProtKB/Swiss-Prot:

P2Y14_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY14: view

Function for P2RY14 Gene

Molecular function for P2RY14 Gene

UniProtKB/Swiss-Prot Function:
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Phenotypes From GWAS Catalog for P2RY14 Gene

Gene Ontology (GO) - Molecular Function for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IBA,IEA 21873635
GO:0045029 UDP-activated nucleotide receptor activity NAS 10753868
genes like me logo Genes that share ontologies with P2RY14: view
genes like me logo Genes that share phenotypes with P2RY14: view

Animal Models for P2RY14 Gene

MGI Knock Outs for P2RY14:

Animal Model Products

CRISPR Products

  • genomics-online: gRNA clones -