The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functio... See more...

Aliases for P2RY14 Gene

Aliases for P2RY14 Gene

  • Purinergic Receptor P2Y14 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 14 2 3
  • G-Protein Coupled Receptor 105 3 4
  • UDP-Glucose Receptor 3 4
  • P2Y Purinoceptor 14 3 4
  • GPR105 3 4
  • P2Y14 3 4
  • G Protein Coupled Receptor For UDP-Glucose 3
  • G Protein-Coupled Receptor 105 2
  • P2Y(14) Receptor 3
  • P2Y14 Receptor 3
  • KIAA0001 4
  • BPR105 3

External Ids for P2RY14 Gene

Previous HGNC Symbols for P2RY14 Gene

  • GPR105

Previous GeneCards Identifiers for P2RY14 Gene

  • GC03M152412
  • GC03M150929
  • GC03M148302

Summaries for P2RY14 Gene

Entrez Gene Summary for P2RY14 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY14 Gene

P2RY14 (Purinergic Receptor P2Y14) is a Protein Coding gene. Diseases associated with P2RY14 include Orofacial Cleft 8 and Usher Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY12.

UniProtKB/Swiss-Prot Summary for P2RY14 Gene

  • Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Tocris Summary for P2RY14 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY14 Gene

Additional gene information for P2RY14 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RY14 Gene

Genomics for P2RY14 Gene

GeneHancer (GH) Regulatory Elements for P2RY14 Gene

Promoters and enhancers for P2RY14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151274 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 509 +0.8 788 6.1 RELA SPI1 BATF MEIS2 JUNB CTCF ETV6 RUNX3 RELB SCRT2 P2RY14 GPR87 P2RY13 EIF2A lnc-AADACL2-6 MED12L
GH03J151224 Enhancer 1 FANTOM5 ENCODE 27 +51.4 51412 4.5 CTCF TCF12 FOS REST RAD21 SKI TRIM22 TBX3 SMC3 DEK P2RY14 P2RY12 RF00017-4142 GPR171 MED12L
GH03J151264 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +11.6 11627 4.8 EP300 RFX1 BCL11A TCF12 YY1 SPI1 IRF4 POU2F2 EBF1 BMI1 P2RY14 GPR87 SETP11 lnc-GPR87-1 MED12L
GH03J151303 Enhancer 1.1 ENCODE dbSUPER 17.6 -27.7 -27684 5.1 ZNF217 TCF12 JUND TEAD4 ZIC2 REST KLF4 RFX1 CUX1 CHD1 P2RY14 P2RY13 IGSF10 GPR87 ENSG00000286273 MED12L
GH03J151230 Enhancer 0.6 FANTOM5 ENCODE 32.1 +47.7 47713 1.1 ATF7 ETV6 P2RY14 MED12L P2RY13 RF00017-4142 GPR171
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY14

Top Transcription factor binding sites by QIAGEN in the P2RY14 gene promoter:
  • AML1a
  • C/EBPbeta
  • E2F
  • E2F-1
  • FOXD3
  • GR
  • POU3F1
  • RP58
  • SRF
  • SRF (504 AA)

Genomic Locations for P2RY14 Gene

Genomic Locations for P2RY14 Gene
chr3:151,212,115-151,278,628
(GRCh38/hg38)
Size:
66,514 bases
Orientation:
Minus strand
chr3:150,929,905-150,996,255
(GRCh37/hg19)
Size:
66,351 bases
Orientation:
Minus strand

Genomic View for P2RY14 Gene

Genes around P2RY14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY14 Gene

Proteins for P2RY14 Gene

  • Protein details for P2RY14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15391-P2Y14_HUMAN
    Recommended name:
    P2Y purinoceptor 14
    Protein Accession:
    Q15391
    Secondary Accessions:
    • Q8IYT7

    Protein attributes for P2RY14 Gene

    Size:
    338 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY14 Gene

neXtProt entry for P2RY14 Gene

Post-translational modifications for P2RY14 Gene

  • Glycosylation at Asn3 and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY14 Gene

No data available for DME Specific Peptides for P2RY14 Gene

Domains & Families for P2RY14 Gene

Gene Families for P2RY14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY14 Gene

Blocks:
  • UDP-glucose receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for P2RY14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75398, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA (A5JUU3_HUMAN)
  • UDP-glucose receptor (P2Y14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15391

UniProtKB/Swiss-Prot:

P2Y14_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY14: view

Function for P2RY14 Gene

Molecular function for P2RY14 Gene

UniProtKB/Swiss-Prot Function:
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Phenotypes From GWAS Catalog for P2RY14 Gene

Gene Ontology (GO) - Molecular Function for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IBA,IEA 21873635
GO:0045029 UDP-activated nucleotide receptor activity NAS 10753868
genes like me logo Genes that share ontologies with P2RY14: view
genes like me logo Genes that share phenotypes with P2RY14: view

Animal Models for P2RY14 Gene

MGI Knock Outs for P2RY14:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for P2RY14 Gene

Localization for P2RY14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY14 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 10753868
genes like me logo Genes that share ontologies with P2RY14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY14 Gene

Pathways & Interactions for P2RY14 Gene

genes like me logo Genes that share pathways with P2RY14: view

Pathways by source for P2RY14 Gene

SIGNOR curated interactions for P2RY14 Gene

Activates:

Gene Ontology (GO) - Biological Process for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY14: view

Drugs & Compounds for P2RY14 Gene

(18) Drugs for P2RY14 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0
2-thio-UDP Pharma Full agonist, Agonist 0
MRS2690 Pharma Agonist 0
MRS2802 Pharma Agonist 0
MRS2905 Pharma Agonist 0

(4) Additional Compounds for P2RY14 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha.beta-methylene-2-thio-UDP
Full agonist, Agonist
UDP
Agonist, Full agonist

(5) Tocris Compounds for P2RY14 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY14: view

Transcripts for P2RY14 Gene

mRNA/cDNA for P2RY14 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY14 Gene

No ASD Table

Relevant External Links for P2RY14 Gene

GeneLoc Exon Structure for
P2RY14

Expression for P2RY14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY14 Gene

This gene is overexpressed in Bladder (x4.4), Esophagus - Gastroesophageal Junction (x4.3), and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for P2RY14 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY14 Gene



Protein tissue co-expression partners for P2RY14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RY14

SOURCE GeneReport for Unigene cluster for P2RY14 Gene:

Hs.2465

mRNA Expression by UniProt/SwissProt for P2RY14 Gene:

Q15391-P2Y14_HUMAN
Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

Evidence on tissue expression from TISSUES for P2RY14 Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with P2RY14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY14 Gene

Orthologs for P2RY14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY14 31 30
  • 98.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY14 31 30
  • 84.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY14 31 30
  • 81.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry14 17 31 30
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia P2ry14 30
  • 79.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY14 31
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY14 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY14 31 30
  • 62.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY14 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry14 30
  • 58.31 (n)
zebrafish
(Danio rerio)
Actinopterygii P2RY14 31
  • 43 (a)
OneToOne
Species where no ortholog for P2RY14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY14 Gene

ENSEMBL:
Gene Tree for P2RY14 (if available)
TreeFam:
Gene Tree for P2RY14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY14: view image

Paralogs for P2RY14 Gene

Paralogs for P2RY14 Gene

(13) SIMAP similar genes for P2RY14 Gene using alignment to 3 proteins:

  • P2Y14_HUMAN
  • A5JUU3_HUMAN
  • C9JAB5_HUMAN
genes like me logo Genes that share paralogs with P2RY14: view

Variants for P2RY14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RY14 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
729312 Benign: not provided 151,213,415(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
VAR_035767 A colorectal cancer sample p.Leu140Pro

Additional dbSNP identifiers (rs#s) for P2RY14 Gene

Structural Variations from Database of Genomic Variants (DGV) for P2RY14 Gene

Variant ID Type Subtype PubMed ID
esv2673993 CNV deletion 23128226
esv2759188 CNV gain 17122850
esv3395422 CNV insertion 20981092
esv3598170 CNV loss 21293372
nsv1148641 CNV duplication 26484159
nsv477896 CNV novel sequence insertion 20440878
nsv592045 CNV gain 21841781
nsv979890 CNV duplication 23825009

Variation tolerance for P2RY14 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY14 Gene

Disorders for P2RY14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for P2RY14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
orofacial cleft 8
  • ofc8
usher syndrome
  • retinitis pigmentosa-deafness syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for P2RY14

genes like me logo Genes that share disorders with P2RY14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY14 Gene

Publications for P2RY14 Gene

  1. Creation of GPCR-based chemical sensors by directed evolution in yeast. (PMID: 16263727) Ault AD … Broach JR (Protein engineering, design & selection : PEDS 2006) 3 23 54
  2. P2 receptors activated by uracil nucleotides--an update. (PMID: 16475938) Brunschweiger A … Müller CE (Current medicinal chemistry 2006) 3 23 54
  3. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. (PMID: 16109883) Müller T … Idzko M (American journal of respiratory cell and molecular biology 2005) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. (PMID: 12902497) Skelton L … Platt A (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 23 54

Products for P2RY14 Gene

Sources for P2RY14 Gene