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Aliases for P2RY13 Gene

Aliases for P2RY13 Gene

  • Purinergic Receptor P2Y13 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 13 2 3
  • G Protein-Coupled Receptor 86 2 3
  • G-Protein Coupled Receptor 94 3 4
  • GPR86 3 4
  • GPR94 3 4
  • P2Y13 3 4
  • G-Protein Coupled Receptor 86 4
  • P2Y Purinoceptor 13 3
  • FKSG77 3
  • GPCR1 3
  • SP174 3

External Ids for P2RY13 Gene

Previous HGNC Symbols for P2RY13 Gene

  • GPR94
  • GPR86

Previous GeneCards Identifiers for P2RY13 Gene

  • GC03M152526
  • GC03M151044
  • GC03M148417

Summaries for P2RY13 Gene

Entrez Gene Summary for P2RY13 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]

GeneCards Summary for P2RY13 Gene

P2RY13 (Purinergic Receptor P2Y13) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY12.

UniProtKB/Swiss-Prot for P2RY13 Gene

  • Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

Tocris Summary for P2RY13 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY13 Gene

Additional gene information for P2RY13 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY13 Gene

Genomics for P2RY13 Gene

GeneHancer (GH) Regulatory Elements for P2RY13 Gene

Promoters and enhancers for P2RY13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151327 Promoter/Enhancer 1 Ensembl ENCODE 650.7 +0.9 922 1.5 CTCF ZNF143 ZNF384 ZNF444 P2RY13 GPR87 MED12L
GH03J151329 Promoter 0.5 EPDnew 650.7 0.0 -20 0.1 P2RY13 P2RY12 MED12L
GH03J151345 Enhancer 0.9 FANTOM5 Ensembl ENCODE 26 -17.3 -17297 2.5 POLR2A MAX MYC P2RY13 GPR87 P2RY14 P2RY12 CLRN1 MED12L
GH03J151274 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 +51.7 51709 6.1 MEIS2 JUNB BATF RELA SCRT2 ETV6 RUNX3 SPI1 P2RY14 GC03P151277 GPR87 P2RY13 EIF2A MED12L
GH03J151303 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.6 +23.2 23237 5.1 CLOCK ARID4B NEUROD1 SIN3A E2F8 FOS DEK MAFF ATF4 ZNF610 P2RY14 P2RY13 IGSF10 GPR87 PIR58282 MED12L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY13 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • PPAR-alpha
  • C/EBPbeta
  • POU3F2
  • LUN-1
  • SRF
  • SRF (504 AA)
  • Pax-4a

Genomic Locations for P2RY13 Gene

Genomic Locations for P2RY13 Gene
chr3:151,326,308-151,329,549
(GRCh38/hg38)
Size:
3,242 bases
Orientation:
Minus strand
chr3:151,044,096-151,047,337
(GRCh37/hg19)
Size:
3,242 bases
Orientation:
Minus strand

Genomic View for P2RY13 Gene

Genes around P2RY13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY13 Gene

Proteins for P2RY13 Gene

  • Protein details for P2RY13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPV8-P2Y13_HUMAN
    Recommended name:
    P2Y purinoceptor 13
    Protein Accession:
    Q9BPV8
    Secondary Accessions:
    • B2R827
    • Q05C50
    • Q6DKN4
    • Q8IUT5
    • Q8TDU7
    • Q9BY61

    Protein attributes for P2RY13 Gene

    Size:
    354 amino acids
    Molecular mass:
    40789 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.
    SequenceCaution:
    • Sequence=AAH29363.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH41116.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY13 Gene

    Alternative splice isoforms for P2RY13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for P2RY13 Gene

Post-translational modifications for P2RY13 Gene

  • Glycosylation at Asn285, isoforms=231, and isoforms=223
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY13 Gene

Domains & Families for P2RY13 Gene

Gene Families for P2RY13 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY13 Gene

Suggested Antigen Peptide Sequences for P2RY13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPV8

UniProtKB/Swiss-Prot:

P2Y13_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY13: view

Function for P2RY13 Gene

Molecular function for P2RY13 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

Gene Ontology (GO) - Molecular Function for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with P2RY13: view
genes like me logo Genes that share phenotypes with P2RY13: view

Animal Models for P2RY13 Gene

MGI Knock Outs for P2RY13:

Animal Model Products

CRISPR Products

miRNA for P2RY13 Gene

miRTarBase miRNAs that target P2RY13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY13 Gene

Localization for P2RY13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY13 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY13 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY13 Gene

Pathways & Interactions for P2RY13 Gene

genes like me logo Genes that share pathways with P2RY13: view

Interacting Proteins for P2RY13 Gene

Gene Ontology (GO) - Biological Process for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0008150 biological_process ND --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY13: view

No data available for SIGNOR curated interactions for P2RY13 Gene

Drugs & Compounds for P2RY13 Gene

(21) Drugs for P2RY13 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cangrelor Approved Pharma Antagonist 21
Suramin Approved, Investigational Pharma Antagonist, Activator, antagonist 18
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
MC-1 Investigational Pharma 0
[<sup>33</sup>P]2MeSADP Pharma Full agonist, Agonist 0

(3) Additional Compounds for P2RY13 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Adpbetas
Full agonist, Agonist
ATPgammaS
Full agonist, Agonist, Partial agonist

(5) Tocris Compounds for P2RY13 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY13: view

Transcripts for P2RY13 Gene

mRNA/cDNA for P2RY13 Gene

Unigene Clusters for P2RY13 Gene

Purinergic receptor P2Y, G-protein coupled, 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY13 Gene

No ASD Table

Relevant External Links for P2RY13 Gene

GeneLoc Exon Structure for
P2RY13
ECgene alternative splicing isoforms for
P2RY13

Expression for P2RY13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY13 Gene

This gene is overexpressed in Whole Blood (x39.2) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for P2RY13 Gene

This gene is overexpressed in Plasma (32.4), Liver (29.0), and Monocytes (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY13 Gene



Protein tissue co-expression partners for P2RY13 Gene

NURSA nuclear receptor signaling pathways regulating expression of P2RY13 Gene:

P2RY13

SOURCE GeneReport for Unigene cluster for P2RY13 Gene:

Hs.546396

mRNA Expression by UniProt/SwissProt for P2RY13 Gene:

Q9BPV8-P2Y13_HUMAN
Tissue specificity: Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.

Evidence on tissue expression from TISSUES for P2RY13 Gene

  • Nervous system(4.4)
  • Spleen(4.3)
  • Heart(4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with P2RY13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY13 Gene

Orthologs for P2RY13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY13 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY13 34 33
  • 85.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY13 34 33
  • 84.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry13 16 34 33
  • 80.04 (n)
rat
(Rattus norvegicus)
Mammalia P2ry13 33
  • 80.04 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RY13 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY13 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749756 33
  • 65.44 (n)
P2RY13 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY13 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry13 33
  • 58.72 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329592 33
  • 53.63 (n)
p2ry13 34
  • 46 (a)
OneToOne
Species where no ortholog for P2RY13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY13 Gene

ENSEMBL:
Gene Tree for P2RY13 (if available)
TreeFam:
Gene Tree for P2RY13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY13: view image

Paralogs for P2RY13 Gene

Paralogs for P2RY13 Gene

(9) SIMAP similar genes for P2RY13 Gene using alignment to 2 proteins:

  • P2Y13_HUMAN
  • G4XH60_HUMAN
genes like me logo Genes that share paralogs with P2RY13: view

Variants for P2RY13 Gene

Sequence variations from dbSNP and Humsavar for P2RY13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000024182 -- 151,329,251(-) A/G intron_variant
rs1000193151 -- 151,329,982(-) T/C upstream_transcript_variant
rs1000530433 -- 151,328,283(-) A/G coding_sequence_variant, intron_variant, missense_variant
rs1001850633 -- 151,327,244(-) G/A 3_prime_UTR_variant
rs1002219977 -- 151,326,598(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY13 Gene

Variant ID Type Subtype PubMed ID
nsv592045 CNV gain 21841781
nsv829757 CNV loss 17160897
nsv954492 CNV duplication 24416366

Variation tolerance for P2RY13 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY13 Gene

Disorders for P2RY13 Gene

Additional Disease Information for P2RY13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for P2RY13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY13 Gene

Publications for P2RY13 Gene

  1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T … Hellebrand S (Journal of molecular biology 2001) 2 3 4 22 58
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. (PMID: 11961076) Zhang FL … Monsma F (The Journal of pharmacology and experimental therapeutics 2002) 3 22 58
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58

Products for P2RY13 Gene

Sources for P2RY13 Gene

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