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The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
P2RY11 (Purinergic Receptor P2Y11) is a Protein Coding gene. Diseases associated with P2RY11 include Narcolepsy 1 and Narcolepsy. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is RXFP3.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0030594 | neurotransmitter receptor activity | IDA | 18048695 |
GO:0038023 | signaling receptor activity | TAS | 9405388 |
GO:0045031 | ATP-activated adenosine receptor activity | IBA,IDA | 18048695 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IC | 18048695 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Nucleotide-like (purinergic) receptors |
.01
|
|
5 | GPCR Pathway |
P2Y Receptor Signaling
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | TAS | 9405388 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IDA,TAS | -- |
GO:0007190 | activation of adenylate cyclase activity | TAS | 9405388 |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | TAS | 9405388 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Promethazine | Approved, Investigational | Pharma | Target, inhibitor | 470 | ||
dATP | Experimental | Pharma | Agonist, Full agonist | 0 | ||
NAD | Experimental | Pharma | Agonist, Full agonist, Activator | 0 | ||
Uridine triphosphate | Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation, Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
UTP |
|
Agonist, Full agonist, Partial agonist |
|
|||
2-Methylthioadenosine diphosphate trisodium salt |
|
475193-31-8 |
|
|
Compound | Action | Cas Number |
---|---|---|
2-Methylthioadenosine diphosphate trisodium salt | Potent agonist for P2Y1, P2Y12 and P2Y13 | 475193-31-8 |
MRS 2365 | Highly potent and selective P2Y1 agonist | 436847-09-5 |
MRS 2690 | Potent P2Y14 agonist | 15039-58-4 |
MRS 2693 trisodium salt | Selective P2Y6 agonist | 1448858-83-0 |
PSB 0474 | Potent and selective P2Y6 agonist | 917567-60-3 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | P2RY11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | P2RY11 30 |
|
||
Cow (Bos Taurus) |
Mammalia | P2RY11 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | P2RY11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | p2ry11 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | p2ry11 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ppan 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | lpd-6 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSF1 31 |
|
ManyToMany | |
SSF2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2660 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709320 | Likely Benign: not provided | 10,113,811(+) | C/A | MISSENSE_VARIANT,SYNONYMOUS_VARIANT | |
716471 | Likely Benign: not provided | 10,114,462(+) | G/A | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
725779 | Benign: not provided | 10,113,943(+) | C/T | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
728169 | Likely Benign: not provided | 10,114,297(+) | C/T | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
728997 | Likely Benign: not provided | 10,114,513(+) | C/G | NONSENSE,THREE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
narcolepsy 1 |
|
|
narcolepsy |
|
|