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Aliases for P2RY11 Gene

Aliases for P2RY11 Gene

  • Purinergic Receptor P2Y11 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 11 2 3
  • P2Y11 3 4
  • P2Y Purinoceptor 11 3

External Ids for P2RY11 Gene

Previous GeneCards Identifiers for P2RY11 Gene

  • GC19P010343
  • GC19P010445
  • GC19P010068
  • GC19P010083
  • GC19P010222
  • GC19P009823
  • GC19P010113
  • GC19P010116
  • GC19P010117
  • GC19P010119
  • GC19P010121
  • GC19P010125
  • GC19P010127
  • GC19P010129

Summaries for P2RY11 Gene

Entrez Gene Summary for P2RY11 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY11 Gene

P2RY11 (Purinergic Receptor P2Y11) is a Protein Coding gene. Diseases associated with P2RY11 include Narcolepsy. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for P2RY11 Gene

  • Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Tocris Summary for P2RY11 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY11 Gene

Additional gene information for P2RY11 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY11 Gene

Genomics for P2RY11 Gene

GeneHancer (GH) Regulatory Elements for P2RY11 Gene

Promoters and enhancers for P2RY11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010110 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 663.4 +1.5 1507 5.2 HDGF HNRNPUL1 PKNOX1 SMAD1 SIN3A ZNF48 POLR2B GLIS2 E2F8 ZNF416 P2RY11 GC19P010134 PIR48091 ILF3 ZNF559 ZNF699 ZNF266 DNMT1 ZNF317 KRI1
GH19J010109 Promoter 0.5 EPDnew 650.7 -1.8 -1776 0.1 GC19P010133 PPAN SNORD105B P2RY11 PPAN-P2RY11 SNORD105
GH19J010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -7.1 -7134 8.3 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 KRI1 FBXL12 ZNF317 LOC100419831 ZNF561
GH19J010118 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.5 +9.0 9025 3.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 EIF3G ZNF266 KRI1 ILF3 ZNF317 RAVER1 PPAN FBXL12 DNMT1 ZNF699
GH19J010197 Enhancer 0.8 Ensembl ENCODE 11.4 +88.2 88187 4.2 GATAD2A ZNF362 L3MBTL2 CEBPB ZMYM3 CEBPG ZNF384 ZBTB40 ZNF316 EGR1 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G SNORD105B P2RY11 PPAN PPAN-P2RY11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY11 gene promoter:
  • FOXO1
  • FOXO1a
  • Max
  • c-Myc
  • AREB6
  • GATA-2
  • LyF-1
  • Pax-6
  • Zic3

Genomic Locations for P2RY11 Gene

Genomic Locations for P2RY11 Gene
3,869 bases
Plus strand
3,869 bases
Plus strand

Genomic View for P2RY11 Gene

Genes around P2RY11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY11 Gene

Proteins for P2RY11 Gene

  • Protein details for P2RY11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2Y purinoceptor 11
    Protein Accession:
    Secondary Accessions:
    • B2R8X9
    • O43190
    • Q9BYU4
    • Q9H170

    Protein attributes for P2RY11 Gene

    374 amino acids
    Molecular mass:
    40345 Da
    Quaternary structure:
    No Data Available
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).
    • Sequence=AAB88674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY11 Gene

neXtProt entry for P2RY11 Gene

Post-translational modifications for P2RY11 Gene

  • Glycosylation at isoforms=179 and Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY11 Gene

Domains & Families for P2RY11 Gene

Gene Families for P2RY11 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY11 Gene

Suggested Antigen Peptide Sequences for P2RY11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY11: view

Function for P2RY11 Gene

Molecular function for P2RY11 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
UniProtKB/Swiss-Prot Induction:
Increased by DMSO and retinoic acid.

Phenotypes From GWAS Catalog for P2RY11 Gene

Gene Ontology (GO) - Molecular Function for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0030594 neurotransmitter receptor activity IDA 18048695
GO:0038023 signaling receptor activity TAS 9405388
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY11: view
genes like me logo Genes that share phenotypes with P2RY11: view

Human Phenotype Ontology for P2RY11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY11 Gene

Localization for P2RY11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY11 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 18048695
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY11 Gene

Pathways & Interactions for P2RY11 Gene

genes like me logo Genes that share pathways with P2RY11: view

Pathways by source for P2RY11 Gene

Gene Ontology (GO) - Biological Process for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0006952 defense response TAS 9405388
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA,TAS --
GO:0007190 activation of adenylate cyclase activity TAS 9405388
genes like me logo Genes that share ontologies with P2RY11: view

No data available for SIGNOR curated interactions for P2RY11 Gene

Drugs & Compounds for P2RY11 Gene

(24) Drugs for P2RY11 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved, Investigational Pharma Antagonist, Activator, antagonist 18
calcium Approved Nutra 0
dATP Experimental Pharma Full agonist, Agonist 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker, Target 0

(6) Additional Compounds for P2RY11 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist, Partial agonist
Full agonist, Agonist
Full agonist, Agonist, Partial agonist

(5) Tocris Compounds for P2RY11 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY11: view

Transcripts for P2RY11 Gene

mRNA/cDNA for P2RY11 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(272) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY11 Gene

Purinergic receptor P2Y, G-protein coupled, 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY11

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY11 Gene

No ASD Table

Relevant External Links for P2RY11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RY11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY11 Gene

Protein differential expression in normal tissues from HIPED for P2RY11 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY11 Gene

Protein tissue co-expression partners for P2RY11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RY11 Gene:


SOURCE GeneReport for Unigene cluster for P2RY11 Gene:


mRNA Expression by UniProt/SwissProt for P2RY11 Gene:

Tissue specificity: Highest expression in liver and spleen.

Evidence on tissue expression from TISSUES for P2RY11 Gene

  • Nervous system(4.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
  • heart
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with P2RY11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for P2RY11 Gene

Orthologs for P2RY11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for P2RY11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia P2RY11 34 33
  • 98.57 (n)
(Canis familiaris)
Mammalia P2RY11 33
  • 79.41 (n)
(Bos Taurus)
Mammalia P2RY11 34 33
  • 78.62 (n)
(Monodelphis domestica)
Mammalia P2RY11 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry11 33
  • 55.52 (n)
(Danio rerio)
Actinopterygii p2ry11 33
  • 51.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta ppan 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea lpd-6 34
  • 5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 34
  • 8 (a)
SSF2 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 34
  • 8 (a)
Species where no ortholog for P2RY11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for P2RY11 Gene

Gene Tree for P2RY11 (if available)
Gene Tree for P2RY11 (if available)
Evolutionary constrained regions (ECRs) for P2RY11: view image

Paralogs for P2RY11 Gene

(1) SIMAP similar genes for P2RY11 Gene using alignment to 1 proteins:

  • P2Y11_HUMAN
genes like me logo Genes that share paralogs with P2RY11: view

Variants for P2RY11 Gene

Sequence variations from dbSNP and Humsavar for P2RY11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs12460842 association, Cataplexy and narcolepsy 10,111,519(+) A/G upstream_transcript_variant
rs2305795 association, Cataplexy and narcolepsy 10,115,376(+) G/A 3_prime_UTR_variant
rs1000302985 -- 10,109,677(+) C/G upstream_transcript_variant
rs1001315406 -- 10,113,348(+) G/A intron_variant
rs1003246665 -- 10,115,266(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY11 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for P2RY11 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY11 Gene

Disorders for P2RY11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY11 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for P2RY11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with P2RY11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY11 Gene

Publications for P2RY11 Gene

  1. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. (PMID: 9405388) Communi D … Boeynaems JM (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. (PMID: 17135283) Amisten S … Erlinge D (European heart journal 2007) 3 22 44 58
  3. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D … Boeynaems JM (The Journal of biological chemistry 2001) 3 4 22 58
  4. Common variants in P2RY11 are associated with narcolepsy. (PMID: 21170044) Kornum BR … Mignot E (Nature genetics 2011) 3 44 58
  5. NAADP+ is an agonist of the human P2Y11 purinergic receptor. (PMID: 17707504) Moreschi I … De Flora A (Cell calcium 2008) 3 22 58

Products for P2RY11 Gene

Sources for P2RY11 Gene

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