The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016] See more...

Aliases for P2RY10 Gene

Aliases for P2RY10 Gene

  • P2Y Receptor Family Member 10 2 3 5
  • P2Y10 2 3 4
  • Purinergic Receptor P2Y, G-Protein Coupled, 10 2 3
  • Putative P2Y Purinoceptor 10 3 4
  • Purinergic Receptor P2Y10 2 3
  • P2Y-Like Receptor 3 4
  • G-Protein Coupled Purinergic Receptor P2Y10 3
  • LYPSR2 3
  • P2RY10 5

External Ids for P2RY10 Gene

Previous GeneCards Identifiers for P2RY10 Gene

  • GC0XP075162
  • GC0XP076242
  • GC0XP076956
  • GC0XP078006
  • GC0XP078087
  • GC0XP078200
  • GC0XP071781

Summaries for P2RY10 Gene

Entrez Gene Summary for P2RY10 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]

GeneCards Summary for P2RY10 Gene

P2RY10 (P2Y Receptor Family Member 10) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR17.

UniProtKB/Swiss-Prot Summary for P2RY10 Gene

Tocris Summary for P2RY10 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RY10 Gene

Genomics for P2RY10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for P2RY10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ078942 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 253.1 +1.5 1541 8.9 POLR2A BCL11A SIN3A NR2C1 EBF1 CBFB MAX ASH2L TAF1 SPI1 P2RY10 HSALNG0138751 ITM2A TAF9B piR-46847-295 GPR174
GH0XJ078882 Promoter 0.3 EPDnew 250.2 -63.3 -63276 0.1 P2RY10 RF00994-1187 piR-61514-221 LPAR4
GH0XJ079142 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +205.4 205384 15.5 BCLAF1 TARDBP TRIM22 MAX BATF ELF1 SCRT1 ZNF24 IKZF1 MTA3 ITM2A P2RY10 GPR174 RTL3 LPAR4 lnc-P2RY10-1 HSALNG0138759
GH0XJ079106 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 6.4 +163.1 163083 3.8 BCL11A SMARCA5 ELF1 FOXA1 IKZF1 NR2F1 ATF2 JUNB ZNF217 ARID3A lnc-GPR174-2 ITM2A GPR174 P2RY10 LPAR4 lnc-P2RY10-1
GH0XJ079138 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +194.2 194169 3.4 BCLAF1 NFIC BCL11A TAL1 EBF1 SPI1 POLR2A ELF1 IKZF1 BMI1 ITM2A P2RY10 GPR174 lnc-P2RY10-1 lnc-GPR174-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY10

Top Transcription factor binding sites by QIAGEN in the P2RY10 gene promoter:
  • AML1a
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-4a
  • POU3F2

Genomic Locations for P2RY10 Gene

Latest Assembly
chrX:78,945,332-78,963,727
(GRCh38/hg38)
Size:
18,396 bases
Orientation:
Plus strand

Previous Assembly
chrX:78,200,888-78,219,224
(GRCh37/hg19 by Entrez Gene)
Size:
18,337 bases
Orientation:
Plus strand

chrX:78,200,829-78,217,451
(GRCh37/hg19 by Ensembl)
Size:
16,623 bases
Orientation:
Plus strand

Genomic View for P2RY10 Gene

Genes around P2RY10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY10 Gene

Proteins for P2RY10 Gene

  • Protein details for P2RY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00398-P2Y10_HUMAN
    Recommended name:
    Putative P2Y purinoceptor 10
    Protein Accession:
    O00398
    Secondary Accessions:
    • D3DTE5
    • Q4VBN7
    • Q86V16

    Protein attributes for P2RY10 Gene

    Size:
    339 amino acids
    Molecular mass:
    38774 Da
    Quaternary structure:
    No Data Available

neXtProt entry for P2RY10 Gene

Post-translational modifications for P2RY10 Gene

  • Glycosylation at Asn16, Asn26, and Asn178
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY10 Gene

No data available for DME Specific Peptides for P2RY10 Gene

Domains & Families for P2RY10 Gene

Gene Families for P2RY10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY10 Gene

Suggested Antigen Peptide Sequences for P2RY10 Gene

GenScript: Design optimal peptide antigens:
  • P2Y-like receptor (P2Y10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00398

UniProtKB/Swiss-Prot:

P2Y10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY10: view

Function for P2RY10 Gene

Molecular function for P2RY10 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Phenotypes From GWAS Catalog for P2RY10 Gene

Gene Ontology (GO) - Molecular Function for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY10: view
genes like me logo Genes that share phenotypes with P2RY10: view

Animal Models for research

  • Taconic Biosciences Mouse Models for P2RY10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY10 Gene

Localization for P2RY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY10 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY10 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY10 Gene

Pathways & Interactions for P2RY10 Gene

genes like me logo Genes that share pathways with P2RY10: view

SIGNOR curated interactions for P2RY10 Gene

Gene Ontology (GO) - Biological Process for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA 21873635
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with P2RY10: view

Drugs & Compounds for P2RY10 Gene

(10) Drugs for P2RY10 Gene - From: DrugBank, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Promethazine Approved, Investigational Pharma Target, inhibitor 494
MC-1 Investigational Pharma 0
JTE-013 Pharma Antagonist 0
LPA Pharma Agonist 0
Sphingosine-1-phosphate Pharma Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(2) Additional Compounds for P2RY10 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?àëlglycerol?àë pyrophos?àëphate
Antagonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8

(5) Tocris Compounds for P2RY10 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY10: view

Transcripts for P2RY10 Gene

mRNA/cDNA for P2RY10 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY10

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for P2RY10 Gene

GeneLoc Exon Structure for
P2RY10

Expression for P2RY10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY10 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for P2RY10 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY10 Gene



Protein tissue co-expression partners for P2RY10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RY10

SOURCE GeneReport for Unigene cluster for P2RY10 Gene:

Hs.296433

mRNA Expression by UniProt/SwissProt for P2RY10 Gene:

O00398-P2Y10_HUMAN
Tissue specificity: Weakly expressed in blood leukocytes.

Evidence on tissue expression from TISSUES for P2RY10 Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with P2RY10: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY10 Gene

Orthologs for P2RY10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY10 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia P2RY10 29 30
  • 90.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia P2RY10 29 30
  • 89.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia P2ry10 29 16 30
  • 85.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia P2ry10 29
  • 85.42 (n)
Oppossum
(Monodelphis domestica)
Mammalia P2RY10 30
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves P2RY10 29
  • 68.37 (n)
-- 30
  • 67 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 54 (a)
OneToMany
-- 30
  • 49 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia p2ry10 29
  • 62.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii p2ry10 29 30
  • 59.14 (n)
OneToOne
Species where no ortholog for P2RY10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for P2RY10 Gene

ENSEMBL:
Gene Tree for P2RY10 (if available)
TreeFam:
Gene Tree for P2RY10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY10: view image
Alliance of Genome Resources:
Additional Orthologs for P2RY10

Paralogs for P2RY10 Gene

(9) SIMAP similar genes for P2RY10 Gene using alignment to 1 proteins:

  • P2Y10_HUMAN

Pseudogenes.org Pseudogenes for P2RY10 Gene

genes like me logo Genes that share paralogs with P2RY10: view

Variants for P2RY10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RY10 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs35763350 Benign: not provided 78,960,916(+) C/T
NM_014499.4(P2RY10):c.396C>T (p.Cys132=)
SYNONYMOUS
rs6618868 -- p.Asn3His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for P2RY10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for P2RY10 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY10
Leiden Open Variation Database (LOVD)
P2RY10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY10 Gene

Disorders for P2RY10 Gene

Additional Disease Information for P2RY10

No disorders were found for P2RY10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY10 Gene

Publications for P2RY10 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K … Ogilvie A (Biochimica et biophysica acta 2000) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Receptors for purines and pyrimidines. (PMID: 9755289) Ralevic V … Burnstock G (Pharmacological reviews 1998) 2 3
  5. Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation. (PMID: 29700886) Hwang SM … Chung IY (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2018) 3

Products for P2RY10 Gene

Sources for P2RY10 Gene