Aliases for P2RY1 Gene
External Ids for P2RY1 Gene
Previous GeneCards Identifiers for P2RY1 Gene
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
GeneCards Summary for P2RY1 Gene
P2RY1 (Purinergic Receptor P2Y1) is a Protein Coding gene. Diseases associated with P2RY1 include Clopidogrel Resistance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is P2RY4.
UniProtKB/Swiss-Prot for P2RY1 Gene
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.