The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular ca... See more...

Aliases for P2RY1 Gene

Aliases for P2RY1 Gene

  • Purinergic Receptor P2Y1 2 3 5
  • P2Y1 2 3 4
  • Suppressing Androgen Receptor In Renal Cell Carcinoma 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 1 2 3
  • P2Y Purinoceptor 1 3 4
  • ADP Receptor 3 4
  • SARCC 2 3
  • P2 Purinoceptor Subtype Y1 3
  • Platelet ADP Receptor 3
  • Purinergic Receptor 4
  • ATP Receptor 3
  • P2RY1 5

External Ids for P2RY1 Gene

Previous GeneCards Identifiers for P2RY1 Gene

  • GC03P149530
  • GC03P153397
  • GC03P153834
  • GC03P153873
  • GC03P154035
  • GC03P152552
  • GC03P149943

Summaries for P2RY1 Gene

Entrez Gene Summary for P2RY1 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY1 Gene

P2RY1 (Purinergic Receptor P2Y1) is a Protein Coding gene. Diseases associated with P2RY1 include Renal Cell Carcinoma, Nonpapillary and Thrombosis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot Summary for P2RY1 Gene

  • Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).

Tocris Summary for P2RY1 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY1 Gene

PharmGKB "VIP" Summary for P2RY1 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for P2RY1 Gene

Genomics for P2RY1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for P2RY1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J152834 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 250.7 +1.5 1470 5.2 NCOR1 MYC ZNF600 IKZF1 ZNF592 NFIC ZIC2 POLR2A ZBTB10 REST P2RY1 lnc-P2RY1-1 RAP2B
GH03J152857 Enhancer 1 FANTOM5 Ensembl 14.5 +24.3 24270 5.6 NCOR1 ARNT ZNF316 NFE2 MYNN ATF1 EHMT2 HDAC2 MAFG NRF1 P2RY1 RAP2B HSALNG0029900-001 HSALNG0029903
GH03J152609 Enhancer 0.6 Ensembl ENCODE 17.7 -225.2 -225214 2.6 ETS1 POU5F1 NANOG POLR2A P2RY1 piR-48950-126 HSALNG0029888 MBNL1
GH03J152639 Enhancer 0.7 Ensembl ENCODE 10.1 -195.9 -195930 0.8 RXRA ZBTB33 IRF9 MAX HNF4A CEBPB ATF3 MNT SP1 CEBPG P2RY1 HSALNG0029888 ENSG00000244545 MBNL1
GH03J152768 Enhancer 0.6 Ensembl 10.8 -65.5 -65530 1.2 CEBPB BATF NFATC1 ATF2 JUNB ZBED1 PKNOX1 CREM POLR2A ETV6 lnc-P2RY1-2 P2RY1 lnc-P2RY1-5 MBNL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RY1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RY1

Top Transcription factor binding sites by QIAGEN in the P2RY1 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx2-2
  • RSRFC4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for P2RY1 Gene

Latest Assembly
chr3:152,835,131-152,841,439
(GRCh38/hg38)
Size:
6,309 bases
Orientation:
Plus strand

Previous Assembly
chr3:152,552,920-152,559,228
(GRCh37/hg19 by Entrez Gene)
Size:
6,309 bases
Orientation:
Plus strand

chr3:152,552,736-152,555,841
(GRCh37/hg19 by Ensembl)
Size:
3,106 bases
Orientation:
Plus strand

Genomic View for P2RY1 Gene

Genes around P2RY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY1 Gene

Proteins for P2RY1 Gene

  • Protein details for P2RY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47900-P2RY1_HUMAN
    Recommended name:
    P2Y purinoceptor 1
    Protein Accession:
    P47900

    Protein attributes for P2RY1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42072 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY1 Gene

neXtProt entry for P2RY1 Gene

Post-translational modifications for P2RY1 Gene

  • Glycosylation at Asn11, Asn27, Asn113, and Asn197
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for P2RY1
  • Boster Bio Antibodies for P2RY1
  • Santa Cruz Biotechnology (SCBT) Antibodies for P2RY1

No data available for DME Specific Peptides for P2RY1 Gene

Domains & Families for P2RY1 Gene

Gene Families for P2RY1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for P2RY1 Gene

InterPro:
Blocks:
  • P2 purinoceptor signature
  • P2Y purinoceptor signature

Suggested Antigen Peptide Sequences for P2RY1 Gene

GenScript: Design optimal peptide antigens:
  • Purinergic receptor (P2RY1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47900

UniProtKB/Swiss-Prot:

P2RY1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY1: view

Function for P2RY1 Gene

Molecular function for P2RY1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).
UniProtKB/Swiss-Prot EnzymeRegulation:
ATP functions as antagonist and inhibits ADP-induced mobilization of Ca(2+) (PubMed:9038354). The P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P inhibit downstream signaling mediated by mobilization of Ca(2+) from intracellular stores, and platelet shape changes in response to extracellular ADP (PubMed:9442040).
GENATLAS Biochemistry:
purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to 2 methylthio-ADP,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for P2RY1 Gene

Gene Ontology (GO) - Molecular Function for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001621 ADP receptor activity IMP 9442040
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 9671706
GO:0005524 ATP binding IMP 25822790
genes like me logo Genes that share ontologies with P2RY1: view
genes like me logo Genes that share phenotypes with P2RY1: view

Animal Models for P2RY1 Gene

MGI Knock Outs for P2RY1:

Animal Models for research

  • Taconic Biosciences Mouse Models for P2RY1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY1 Gene

Localization for P2RY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 25822790
GO:0005929 cilium IDA 28154160
GO:0009986 cell surface HDA 23382103
genes like me logo Genes that share ontologies with P2RY1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY1 Gene

Pathways & Interactions for P2RY1 Gene

genes like me logo Genes that share pathways with P2RY1: view

Pathways by source for P2RY1 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY1 Gene
  • Signal transduction IP3 signaling
1 Qiagen pathway for P2RY1 Gene
  • P2Y Receptor Signaling

SIGNOR curated interactions for P2RY1 Gene

Gene Ontology (GO) - Biological Process for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8630005
GO:0007186 G protein-coupled receptor signaling pathway ISS,TAS --
genes like me logo Genes that share ontologies with P2RY1: view

Drugs & Compounds for P2RY1 Gene

(53) Drugs for P2RY1 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma 1600
Promethazine Approved, Investigational Pharma Target, inhibitor 494
Suramin Investigational Pharma Antagonist 19
ATP Investigational Nutra Agonist, Partial agonist, Antagonist 0
MC-1 Investigational Pharma 0

(21) Additional Compounds for P2RY1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist 58-64-0
2-ClATP
Antagonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8

(5) Tocris Compounds for P2RY1 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY1: view

Transcripts for P2RY1 Gene

mRNA/cDNA for P2RY1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RY1

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY1 Gene

No ASD Table

Relevant External Links for P2RY1 Gene

GeneLoc Exon Structure for
P2RY1

Expression for P2RY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY1 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.1).

Protein differential expression in normal tissues from HIPED for P2RY1 Gene

This gene is overexpressed in Retina (38.5), Platelet (15.2), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY1 Gene



Protein tissue co-expression partners for P2RY1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RY1

SOURCE GeneReport for Unigene cluster for P2RY1 Gene:

Hs.654526

Evidence on tissue expression from TISSUES for P2RY1 Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Lung(4.4)
  • Heart(2.5)
  • Muscle(2.4)
  • Skin(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with P2RY1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY1 Gene

Orthologs for P2RY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia P2RY1 29 30
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia P2RY1 29 30
  • 91.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia P2RY1 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia P2ry1 29
  • 87.85 (n)
Mouse
(Mus musculus)
Mammalia P2ry1 29 16 30
  • 87.13 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia P2RY1 30
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia P2RY1 29 30
  • 81.53 (n)
OneToOne
Chicken
(Gallus gallus)
Aves P2RY1 29 30
  • 77.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia P2RY1 30
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia p2ry1 29
  • 75.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia p2ry1-A 29
Zebrafish
(Danio rerio)
Actinopterygii LOC100003922 29
  • 72.04 (n)
P2RY1 30
  • 72 (a)
OneToOne
Species where no ortholog for P2RY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for P2RY1 Gene

ENSEMBL:
Gene Tree for P2RY1 (if available)
TreeFam:
Gene Tree for P2RY1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RY1: view image
Alliance of Genome Resources:
Additional Orthologs for P2RY1

Paralogs for P2RY1 Gene

(30) SIMAP similar genes for P2RY1 Gene using alignment to 1 proteins:

  • P2RY1_HUMAN
genes like me logo Genes that share paralogs with P2RY1: view

Variants for P2RY1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for P2RY1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for P2RY1 Gene

Variant ID Type Subtype PubMed ID
nsv1008013 CNV gain 25217958
nsv998184 CNV gain 25217958

Variation tolerance for P2RY1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY1
Leiden Open Variation Database (LOVD)
P2RY1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RY1 Gene

Disorders for P2RY1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for P2RY1 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
renal cell carcinoma, nonpapillary
  • rcc
thrombosis
  • thrombosis of blood vessel
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards
Search P2RY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for P2RY1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with P2RY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY1 Gene

Publications for P2RY1 Gene

  1. Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PMID: 8579591) Ayyanathan K … Kunapuli SP (Biochemical and biophysical research communications 1996) 2 3 4 22
  2. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. (PMID: 19637098) Storey RF … Armstrong M (Platelets 2009) 3 22 40
  3. Genetics of platelet reactivity in normal, healthy individuals. (PMID: 19740098) Kunicki TJ … Nugent DJ (Journal of thrombosis and haemostasis : JTH 2009) 3 22 40
  4. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. (PMID: 17559347) Li Q … Zhou HH (Pharmacogenomics 2007) 3 22 40
  5. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. (PMID: 16581111) Lev EI … Kleiman NS (Thrombosis research 2007) 3 22 40

Products for P2RY1 Gene

Sources for P2RY1 Gene