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Aliases for P2RY1 Gene

Aliases for P2RY1 Gene

  • Purinergic Receptor P2Y1 2 3 5
  • Suppressing Androgen Receptor In Renal Cell Carcinoma 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 1 2 3
  • ATP Receptor 3 4
  • P2Y1 3 4
  • P2 Purinoceptor Subtype Y1 3
  • Platelet ADP Receptor 3
  • Purinergic Receptor 4
  • P2Y Purinoceptor 1 3
  • SARCC 3

External Ids for P2RY1 Gene

Previous GeneCards Identifiers for P2RY1 Gene

  • GC03P149530
  • GC03P153397
  • GC03P153834
  • GC03P153873
  • GC03P154035
  • GC03P152552
  • GC03P149943

Summaries for P2RY1 Gene

Entrez Gene Summary for P2RY1 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY1 Gene

P2RY1 (Purinergic Receptor P2Y1) is a Protein Coding gene. Diseases associated with P2RY1 include Clopidogrel Resistance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot for P2RY1 Gene

  • Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

Tocris Summary for P2RY1 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY1 Gene

PharmGKB "VIP" Summary for P2RY1 Gene

Additional gene information for P2RY1 Gene

No data available for CIViC summary , fRNAdb sequence ontologies and piRNA Summary for P2RY1 Gene

Genomics for P2RY1 Gene

GeneHancer (GH) Regulatory Elements for P2RY1 Gene

Promoters and enhancers for P2RY1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I152834 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.3 1292 3.6 PKNOX1 ATF1 ARNT SIN3A ZNF2 ZNF121 POLR2B GLIS2 CBX5 KLF7 P2RY1 GC03P152840
GH03I152857 Enhancer 0.9 FANTOM5 14.5 +22.6 22626 0.4 HDAC1 PKNOX1 ATF1 ARNT CHAMP1 ZNF766 ATF7 CREM CEBPB SMARCA4 P2RY1 RAP2B GC03P152840 GC03P153002
GH03I152609 Enhancer 0.4 ENCODE 15.5 -224.4 -224378 1.8 POLR2A POU5F1 ETS1 P2RY1 GC03P152593 LOC102724289
GH03I152656 Enhancer 0.9 Ensembl ENCODE 5.4 -177.6 -177595 1.9 BRD4 LEF1 ETV1 TEAD4 E4F1 ETS1 GATA3 RCOR1 SMARCE1 ZNF639 P2RY1 LOC102724289 PIR32822
GH03I152603 Enhancer 0.4 ENCODE 8.9 -231.3 -231272 0.8 POU5F1 ZBTB33 ETS1 P2RY1 GC03P152593 LOC102724289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around P2RY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY1 gene promoter:

Genomic Locations for P2RY1 Gene

Genomic Locations for P2RY1 Gene
chr3:152,834,693-152,841,439
(GRCh38/hg38)
Size:
6,747 bases
Orientation:
Plus strand
chr3:152,552,736-152,555,845
(GRCh37/hg19)

Genomic View for P2RY1 Gene

Genes around P2RY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY1 Gene

Proteins for P2RY1 Gene

  • Protein details for P2RY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47900-P2RY1_HUMAN
    Recommended name:
    P2Y purinoceptor 1
    Protein Accession:
    P47900

    Protein attributes for P2RY1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42072 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY1 Gene

neXtProt entry for P2RY1 Gene

Post-translational modifications for P2RY1 Gene

  • Glycosylation at isoforms=11, Asn27, isoforms=113, and Asn197
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY1 Gene

Domains & Families for P2RY1 Gene

Gene Families for P2RY1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for P2RY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47900

UniProtKB/Swiss-Prot:

P2RY1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY1: view

Function for P2RY1 Gene

Molecular function for P2RY1 Gene

GENATLAS Biochemistry:
purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to 2 methylthio-ADP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
UniProtKB/Swiss-Prot Induction:
Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Phenotypes From GWAS Catalog for P2RY1 Gene

Gene Ontology (GO) - Molecular Function for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity TAS 8630005
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 9671706
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with P2RY1: view
genes like me logo Genes that share phenotypes with P2RY1: view

Animal Models for P2RY1 Gene

MGI Knock Outs for P2RY1:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY1

Clone Products

  • Addgene plasmids for P2RY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY1 Gene

Localization for P2RY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS 8630005
GO:0009986 cell surface IDA,HDA 23382103
GO:0014069 postsynaptic density ISS,IEA --
genes like me logo Genes that share ontologies with P2RY1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY1 Gene

Pathways & Interactions for P2RY1 Gene

genes like me logo Genes that share pathways with P2RY1: view

Gene Ontology (GO) - Biological Process for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8630005
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with P2RY1: view

No data available for SIGNOR curated interactions for P2RY1 Gene

Drugs & Compounds for P2RY1 Gene

(48) Drugs for P2RY1 Gene - From: PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved, Investigational Pharma Antagonist, antagonist 18
Aspirin Approved, Vet_approved Pharma Channel blocker 1232
calcium Approved Nutra 0
ATP Investigational Nutra Agonist 0
MC-1 Investigational Pharma 0

(31) Additional Compounds for P2RY1 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
2,2-pyridylisatogen tosylate
Antagonist
2,3-ddATP
Partial agonist, Agonist
2-ClATP
Antagonist
adenosine-3-5-bisphosphate
Antagonist

(5) Tocris Compounds for P2RY1 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY1: view

Transcripts for P2RY1 Gene

mRNA/cDNA for P2RY1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY1 Gene

Purinergic receptor P2Y, G-protein coupled, 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for P2RY1

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY1 Gene

No ASD Table

Relevant External Links for P2RY1 Gene

GeneLoc Exon Structure for
P2RY1
ECgene alternative splicing isoforms for
P2RY1

Expression for P2RY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY1 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.1).

Protein differential expression in normal tissues from HIPED for P2RY1 Gene

This gene is overexpressed in Retina (38.5), Platelet (15.2), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY1 Gene



Protein tissue co-expression partners for P2RY1 Gene

NURSA nuclear receptor signaling pathways regulating expression of P2RY1 Gene:

P2RY1

SOURCE GeneReport for Unigene cluster for P2RY1 Gene:

Hs.654526

Evidence on tissue expression from TISSUES for P2RY1 Gene

  • Blood(4.5)
  • Nervous system(4.5)
  • Lung(4.2)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with P2RY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY1 Gene

Orthologs for P2RY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY1 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia P2RY1 33 34
  • 91.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY1 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry1 33
  • 87.85 (n)
mouse
(Mus musculus)
Mammalia P2ry1 33 16 34
  • 87.13 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RY1 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY1 33 34
  • 81.53 (n)
chicken
(Gallus gallus)
Aves P2RY1 33 34
  • 77.9 (n)
lizard
(Anolis carolinensis)
Reptilia P2RY1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry1 33
  • 75.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia p2ry1-A 33
zebrafish
(Danio rerio)
Actinopterygii LOC100003922 33
  • 72.04 (n)
P2RY1 34
  • 72 (a)
OneToOne
Species where no ortholog for P2RY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY1 Gene

ENSEMBL:
Gene Tree for P2RY1 (if available)
TreeFam:
Gene Tree for P2RY1 (if available)

Paralogs for P2RY1 Gene

Paralogs for P2RY1 Gene

genes like me logo Genes that share paralogs with P2RY1: view

Variants for P2RY1 Gene

Sequence variations from dbSNP and Humsavar for P2RY1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000066360 -- 152,833,406(+) A/G upstream_transcript_variant
rs1000511844 -- 152,838,163(+) A/G 3_prime_UTR_variant
rs1000917673 -- 152,838,074(+) A/T 3_prime_UTR_variant
rs1001235390 -- 152,836,843(+) G/A coding_sequence_variant, missense_variant
rs1001578322 -- 152,832,967(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY1 Gene

Variant ID Type Subtype PubMed ID
nsv1008013 CNV gain 25217958
nsv998184 CNV gain 25217958

Variation tolerance for P2RY1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY1 Gene

Disorders for P2RY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards
Search P2RY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for P2RY1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with P2RY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY1 Gene

Publications for P2RY1 Gene

  1. Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PMID: 8579591) Ayyanathan K … Kunapuli SP (Biochemical and biophysical research communications 1996) 2 3 4 22 58
  2. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. (PMID: 19637098) Storey RF … Armstrong M (Platelets 2009) 3 22 44 58
  3. Genetics of platelet reactivity in normal, healthy individuals. (PMID: 19740098) Kunicki TJ … Nugent DJ (Journal of thrombosis and haemostasis : JTH 2009) 3 22 44 58
  4. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. (PMID: 16581111) Lev EI … Kleiman NS (Thrombosis research 2007) 3 22 44 58
  5. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. (PMID: 17559347) Li Q … Zhou HH (Pharmacogenomics 2007) 3 22 44 58

Products for P2RY1 Gene

  • Addgene plasmids for P2RY1

Sources for P2RY1 Gene

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