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The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to c... See more...
Aliases for P2RX7 Gene
Aliases for P2RX7 Gene
External Ids for P2RX7 Gene
- HGNC: 8537
- Entrez Gene: 5027
- Ensembl: ENSG00000089041
- OMIM: 602566
- UniProtKB: Q99572
Previous GeneCards Identifiers for P2RX7 Gene
- GC12P120432
- GC12P121185
- GC12P121353
- GC12P119982
- GC12P120033
- GC12P121570
- GC12P118580
- GC12P121186
- GC12P121278
- GC12P122317
- GC12P122396
- GC12P122433
- GC12P122630
- GC12P121334
- GC12P121398
- GC12P121463
- GC12P121522
- GC12P122012
- GC12P122098
- GC12P122173
- GC12P122253
Summaries for P2RX7 Gene
-
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
GeneCards Summary for P2RX7 Gene
P2RX7 (Purinergic Receptor P2X 7) is a Protein Coding gene. Diseases associated with P2RX7 include Tularemia and Extrapulmonary Tuberculosis. Among its related pathways are Neuroscience and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is P2RX4.
UniProtKB/Swiss-Prot Summary for P2RX7 Gene
-
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).
-
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.
Additional gene information for P2RX7 Gene
- HGNC(8537)
- Entrez Gene(5027)
- Ensembl(ENSG00000089041)
- OMIM(602566)
- UniProtKB(Q99572)
- Open Targets Platform(ENSG00000089041)
- Monarch Initiative
- Search for P2RX7 at DataMed
- Search for P2RX7 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RX7 Gene
Genomics for P2RX7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for P2RX7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around P2RX7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RX7
- Top Transcription factor binding sites by QIAGEN in the P2RX7 gene promoter:
-
- CREB
- deltaCREB
- FOXO1
- FOXO1a
- NF-1
- NF-kappaB1
- SREBP-1a
- SREBP-1b
- SREBP-1c
- YY1
Genomic Locations for P2RX7 Gene
Genomic Locations for P2RX7 Gene
- chr12:121,132,819-121,188,032
- (GRCh38/hg38)
- Size:
- 55,214 bases
- Orientation:
- Plus strand
- chr12:121,570,622-121,624,354
- (GRCh37/hg19)
- Size:
- 53,733 bases
- Orientation:
- Plus strand
Genomic View for P2RX7 Gene
Genes around P2RX7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
P2RX7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for P2RX7 Gene
Proteins for P2RX7 Gene
-
Protein details for P2RX7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99572-P2RX7_HUMAN
- Recommended name:
- P2X purinoceptor 7
- Protein Accession:
- Q99572
- A8K2Z0
- E7EMK6
- F5H6P2
- F5H7E8
- F8W951
- O14991
- Q4VKH8
- Q4VKH9
- Q4VKI0
- Q4VKI1
- Q4VKI2
- Q4VKI3
- Q4VKI4
- Q7Z771
- Q96EV7
Protein attributes for P2RX7 Gene
- Size:
- 595 amino acids
- Molecular mass:
- 68585 Da
- Quaternary structure:
-
- Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Interacts (via C-terminus) with EMP2 (PubMed:12107182).
- Miscellaneous:
-
- [Isoform B]: Predominant form in many tissues.
- [Isoform H]: Non-functional channel.
Protein Expression for P2RX7 Gene
Post-translational modifications for P2RX7 Gene
- Phosphorylation results in its inactivation.
- ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.
- Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
-
Glycosylation at Asn187, Asn202, Asn213, Asn241, and Asn284
- NX_Q99572 (NX_Q99572-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- P2RX7_HUMAN (1591)
Other Protein References for P2RX7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences P2RX7 / P2X7 Antibody (LS-B4401) and P2RX7 / P2X7 Antibody (LS-A9585)
- G Biosciences Immunotag™ P2RX7 Antibody
- Creative Diagnostics Anti-P2RX7 (internal region) polyclonal antibody
- Creative Biolabs Recombinant Anti-Human P2RX7 Antibody
- BioLegend P2RX7 Antibody
- Novus Biologicals Antibodies for P2RX7
- Invitrogen Antibodies for P2RX7 (AFLGC-P2RX7)
- antibodies-online: Show 35 available P2RX7 Antibodies ranked by validation data
- Compare Top P2RX7 Antibodies
-
Recommended
- 86 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 40 WB Antibodies (anti-mouse)
- 17 IF Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 27 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for P2RX7
-
Santa Cruz Biotechnology (SCBT) Antibodies for P2RX7
Protein Products
-
OriGene Purified Proteins for P2RX7
- Search Origene for MassSpec and Protein Over-expression Lysates for P2RX7
- Origene Custom Protein Services for P2RX7
-
Signalway Proteins for P2RX7
-
Abcam proteins for P2RX7
Assay Products
No data available for DME Specific Peptides for P2RX7 Gene
Domains & Families for P2RX7 Gene
Gene Families for P2RX7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for P2RX7 Gene
- InterPro:
- Blocks:
-
- ATP P2X receptor
- P2X7 purinoceptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for P2RX7 Gene
- GenScript: Design optimal peptide antigens:
-
- P2X purinoceptor (C6KE32_HUMAN)
- P2X purinoceptor (E7EX72_HUMAN)
- P2X purinoceptor (F5H7E8_HUMAN)
- Purinergic receptor (P2RX7_HUMAN)
- P2X purinoceptor (Q0IJ51_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99572- Family:
-
- Belongs to the P2X receptor family.
Function for P2RX7 Gene
Molecular function for P2RX7 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).
- GENATLAS Biochemistry:
- purinoceptor,P2X7
Phenotypes From GWAS Catalog for P2RX7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | ISS | -- |
| GO:0001614 | purinergic nucleotide receptor activity | IDA | 9038151 |
| GO:0004931 | extracellularly ATP-gated cation channel activity | IBA,IDA | 9038151 |
| GO:0005102 | signaling receptor binding | ISS | 17785580 |
| GO:0005216 | ion channel activity | IEA | -- |
Phenotypes for P2RX7 Gene
- MGI mutant phenotypes for P2RX7:
-
inferred from 8 alleles
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for P2RX7:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased IL-8 secretion
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for P2RX7 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for P2RX7
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for P2RX7 - Select products 50% OFF >
- * P2RX7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for P2RX7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for P2RX7
-
Santa Cruz Biotechnology (SCBT) CRISPR for P2RX7
miRNA for P2RX7 Gene
- miRTarBase miRNAs that target P2RX7
-
- hsa-miR-186-5p (MIRT004356)
- hsa-miR-150-5p (MIRT004357)
- hsa-miR-218-1-3p (MIRT443516)
- hsa-miR-1200 (MIRT443517)
- hsa-miR-378a-5p (MIRT443518)
- hsa-miR-9-3p (MIRT443519)
- hsa-miR-4682 (MIRT443520)
- hsa-miR-544b (MIRT443521)
- hsa-miR-4324 (MIRT443522)
- hsa-miR-876-5p (MIRT529929)
- hsa-miR-3167 (MIRT529930)
- hsa-miR-6880-3p (MIRT529931)
- hsa-miR-4312 (MIRT529932)
- hsa-miR-1324 (MIRT529933)
- hsa-miR-4524b-3p (MIRT529935)
- mmu-miR-216b-5p (MIRT603641)
- mmu-miR-1896 (MIRT603642)
- mmu-miR-1199-5p (MIRT603643)
- mmu-miR-1195 (MIRT603644)
- mmu-miR-3089-5p (MIRT603645)
- mmu-miR-5135 (MIRT603646)
- hsa-miR-6809-3p (MIRT655556)
- hsa-miR-6833-3p (MIRT655557)
- hsa-miR-4768-5p (MIRT655558)
- hsa-miR-4753-3p (MIRT655559)
- hsa-miR-3191-5p (MIRT655560)
- hsa-miR-627-3p (MIRT655561)
- hsa-miR-130b-5p (MIRT655562)
- hsa-miR-3921 (MIRT655563)
- hsa-miR-4653-5p (MIRT655564)
- hsa-miR-301b-5p (MIRT655565)
- hsa-miR-301a-5p (MIRT655566)
- hsa-miR-146a-3p (MIRT655567)
- hsa-miR-216b-5p (MIRT655568)
- hsa-miR-640 (MIRT677134)
- hsa-miR-6821-3p (MIRT677135)
- hsa-miR-6790-3p (MIRT677136)
- hsa-miR-186-3p (MIRT677137)
- hsa-miR-3934-5p (MIRT677138)
- hsa-miR-764 (MIRT677139)
- hsa-miR-125a-3p (MIRT677140)
- hsa-miR-6778-3p (MIRT678525)
- hsa-miR-3653-5p (MIRT678526)
- hsa-miR-520h (MIRT678527)
- hsa-miR-520g-3p (MIRT678528)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for P2RX7
- Browse OriGene Inhibitory RNA Products For P2RX7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX7
Clone Products
- Applied Biological Materials (abm): Clones for P2RX7 - Select products 50% OFF >
- * P2RX7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227216
- MG227219
- MG227233
- MG227440
- MR227216
- MR227216L3
- MR227216L4
- MR227219
- MR227219L3
- MR227219L4
- MR227233
- MR227233L3
- MR227233L4
- MR227440
- MR227440L3
- MR227440L4
- MR230613
- RC222143
- RC222143L1
- RC222143L2
- RC222143L3
- RC222143L4
- RG222143
- RR203697
- RR203697L3
- RR203697L4
- MR227216L3V
- MR227216L4V
- MR227219L3V
- MR227219L4V
- MR227233L3V
- MR227233L4V
- MR227440L3V
- MR227440L4V
- RC222143L1V
- RC222143L2V
- RC222143L3V
- RC222143L4V
- RR203697L3V
- RR203697L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for P2RX7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX7
Cell Line Products
-
Horizon Cell Lines for P2RX7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX7 Gene
Localization for P2RX7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for P2RX7 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| extracellular | 3 |
| mitochondrion | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005639 | integral component of nuclear inner membrane | IBA | 21873635 |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005886 | plasma membrane | ISS,TAS | 17299767 |
| GO:0005887 | integral component of plasma membrane | IC | 9038151 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RX7 Gene
Pathways & Interactions for P2RX7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Platelet homeostasis | ||
| 2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
.01
|
|
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Ca, cAMP and Lipid Signaling | ||
Pathways by source for P2RX7 Gene
9 Reactome pathways for P2RX7 Gene
3 KEGG pathways for P2RX7 Gene
2 R&D Systems pathways for P2RX7 Gene
1 Qiagen pathway for P2RX7 Gene
- Intracellular Calcium Signaling
2 Cell Signaling Technology pathways for P2RX7 Gene
Interacting Proteins for P2RX7 Gene
Selected Interacting proteins:
Q99572-P2RX7_HUMAN
ENSP00000330696
for P2RX7 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for P2RX7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001845 | phagolysosome assembly | IEA | -- |
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for P2RX7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| brilliant blue G | Approved | Pharma | Antagonist | 0 | ||
| Promethazine | Approved, Investigational | Pharma | Target, inhibitor | 470 | ||
| Fentanyl | Approved, Illicit, Investigational, Vet_approved | Pharma | Agonist, Full agonist, Partial agonist | 1229 | ||
| Ivermectin | Approved, Investigational, Vet_approved | Pharma | activator | NAChR/purinergic P2X4 receptor modulator | 126 | |
| DECAVANADATE | Pharma | Antagonist, Activator, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ATPgammaS tetralithium salt |
|
93839-89-5 |
|
|
(5) Tocris Compounds for P2RX7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-Methylthioadenosine triphosphate tetrasodium salt | P2 purinergic agonist | 100020-57-3 |
| ATPgammaS tetralithium salt | P2 agonist; ATP (Cat. No. 3245) analog | 93839-89-5 |
| NF 157 | Selective P2Y11/P2X1 antagonist | 104869-26-3 |
| PPADS tetrasodium salt | P2 purinergic antagonist | 192575-19-2 |
| Suramin hexasodium salt | Non-selective P2 antagonist | 129-46-4 |
(28) ApexBio Compounds for P2RX7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-Methylthioadenosine triphosphate tetrasodium salt | 100020-57-3 | |
| A 438079 | P2X7 receptor antagonist,competitive and selective | 899507-36-9 |
| A 438079 hydrochloride | P2X7 receptor antagonist,competitive and selective | 899431-18-6 |
| A 804598 | P2X7 antagonist,potent and selective | 1125758-85-1 |
| A 839977 | P2X7 antagonist,potent and selective | 870061-27-1 |
| A-740003 | P2X7 receptor antagonist | 861393-28-4 |
| ATPγS tetralithium salt | 93839-89-5 | |
| AZ 10606120 dihydrochloride | Potent P2X7 receptor antagonist | 607378-18-7 |
| AZ 11645373 | Human P2X7 antagonist,potent and selective | 227088-94-0 |
| BzATP triethylammonium salt | 112898-15-4 | |
| GW791343 HCl | P2X7 allosteric modulator | 309712-55-8 |
| iso-PPADS tetrasodium salt | P2 purinoceptors antagonist, specific | 207572-67-6 |
| KN-62 | CaM kinase II inhibitor | 127191-97-3 |
| KN-92 hydrochloride | Inactive derivative of KN-93,control compound | 1431698-47-3 |
| KN-93 | CaMKII inhibitor,selective and cometitive | 139298-40-1 |
| MRS 2219 | 14141-47-0 | |
| NF 023 | 104869-31-0 | |
| NF 110 | 111150-22-2 | |
| NF 157 | 104869-26-3 | |
| NF 279 | 202983-32-2 | |
| NF 449 | purinergic receptor antagonist | 627034-85-9 |
| PPADS tetrasodium salt | 192575-19-2 | |
| PPNDS | 1021868-77-8 | |
| Ro 0437626 | 134362-79-1 | |
| Ro 51 | 1050670-85-3 | |
| RO-3 | 1026582-88-6 | |
| Suramin hexasodium salt | 129-46-4 | |
| TNP-ATP triethylammonium salt | 61368-63-6 |
Transcripts for P2RX7 Gene
mRNA/cDNA for P2RX7 Gene
- 2 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261826 3003 nts (view in UCSC)
- ENST00000328963 5113 nts (view in UCSC)
- ENST00000535250 1872 nts (view in UCSC)
- ENST00000535600 1605 nts (view in UCSC)
- ENST00000535928 546 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for P2RX7 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for P2RX7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for P2RX7
-
Santa Cruz Biotechnology (SCBT) CRISPR for P2RX7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for P2RX7
- Browse OriGene Inhibitory RNA Products For P2RX7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX7
Clone Products
- Applied Biological Materials (abm): Clones for P2RX7 - Select products 50% OFF >
- * P2RX7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227216
- MG227219
- MG227233
- MG227440
- MR227216
- MR227216L3
- MR227216L4
- MR227219
- MR227219L3
- MR227219L4
- MR227233
- MR227233L3
- MR227233L4
- MR227440
- MR227440L3
- MR227440L4
- MR230613
- RC222143
- RC222143L1
- RC222143L2
- RC222143L3
- RC222143L4
- RG222143
- RR203697
- RR203697L3
- RR203697L4
- MR227216L3V
- MR227216L4V
- MR227219L3V
- MR227219L4V
- MR227233L3V
- MR227233L4V
- MR227440L3V
- MR227440L4V
- RC222143L1V
- RC222143L2V
- RC222143L3V
- RC222143L4V
- RR203697L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for P2RX7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX7
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - |
Relevant External Links for P2RX7 Gene
- GeneLoc Exon Structure for
- P2RX7
Expression for P2RX7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for P2RX7 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7), Brain - Substantia nigra (x4.2), and Brain - Hippocampus (x4.1).
This gene is overexpressed in Frontal cortex (33.5), Spinal cord (14.5), and Bone (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for P2RX7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RX7
SOURCE GeneReport for Unigene cluster for P2RX7 Gene:
Hs.729169mRNA Expression by UniProt/SwissProt for P2RX7 Gene:
Q99572-P2RX7_HUMAN
Tissue specificity:
Widely expressed with highest levels in brain and immune tissues.
Evidence on tissue expression from TISSUES for P2RX7 Gene
- Nervous system(4.9)
- Blood(4.6)
- Skin(4.5)
- Liver(4.4)
- Adrenal gland(3.3)
- Kidney(2.7)
- Heart(2.6)
- Muscle(2.6)
- Spleen(2.6)
- Lymph node(2.6)
- Intestine(2.4)
- Eye(2.4)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for P2RX7
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RX7 Gene
Orthologs for P2RX7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | P2RX7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | P2RX7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | P2RX7 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | P2rx7 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | P2RX7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | P2RX7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | P2RX7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490828 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | p2X7 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | p2rx7 30 31 |
|
OneToOne | |
| -- 30 |
|
- Species where no ortholog for P2RX7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for P2RX7 Gene
- ENSEMBL:
- Gene Tree for P2RX7 (if available)
- TreeFam:
- Gene Tree for P2RX7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for P2RX7: view image
Paralogs for P2RX7 Gene
(8) SIMAP similar genes for P2RX7 Gene using alignment to 8 proteins:
- P2RX7_HUMAN
- C6KE32_HUMAN
- F5H237_HUMAN
- F5H2X6_HUMAN
- F5H8E7_HUMAN
- J3KN30_HUMAN
- K4K1I8_HUMAN
- Q0IJ51_HUMAN
Variants for P2RX7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RX7 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716590 | Benign: not provided | 121,162,416(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
| 716992 | Benign: not provided | 121,175,465(+) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 718081 | Likely Benign: not provided | 121,167,605(+) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 723307 | Likely Benign: not provided | 121,154,884(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 725343 | Benign: not provided | 121,154,893(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv307e214 | CNV | gain | 21293372 |
| dgv319e199 | CNV | deletion | 23128226 |
| esv26396 | CNV | gain | 19812545 |
| esv2746483 | CNV | deletion | 23290073 |
| esv2759917 | CNV | loss | 17122850 |
| esv3630934 | CNV | loss | 21293372 |
| esv3630940 | CNV | loss | 21293372 |
| esv3630941 | CNV | loss | 21293372 |
| esv3630942 | CNV | loss | 21293372 |
| esv3630943 | CNV | loss | 21293372 |
| nsv1054878 | CNV | gain | 25217958 |
| nsv1127298 | CNV | deletion | 24896259 |
| nsv521928 | CNV | gain | 19592680 |
| nsv560454 | CNV | loss | 21841781 |
| nsv560455 | CNV | gain | 21841781 |
| nsv832531 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
21.94;
99.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for P2RX7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX7 Gene
Disorders for P2RX7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tularemia |
|
|
| extrapulmonary tuberculosis |
|
|
| leukemia, chronic lymphocytic |
|
|
| ischemia |
|
|
| pulmonary tuberculosis |
|
Search P2RX7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for P2RX7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX7 Gene
Publications for P2RX7 Gene
- The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. (PMID: 9038151) Rassendren F … Surprenant A (The Journal of biological chemistry 1997) 2 3 4 23
- P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians. (PMID: 20164546) Sambasivan V … Hasan Q (Disease markers 2010) 3 23 41
- Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: a preliminary study. (PMID: 19891999) Mrazek F … Petrek M (Human immunology 2010) 3 23 41
- Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 20188863) Taype CA … Shaw MA (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010) 3 23 41
- Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. (PMID: 18971257) Gonnord P … Kanellopoulos JM (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 4 23
ExternalLinks
Products for P2RX7 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for P2RX7
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- Browse OriGene Inhibitory RNA Products For P2RX7
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- OriGene CRISPR knockouts for P2RX7
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- RC222143L1V
- RC222143L2V
- RC222143L3V
- RC222143L4V
- RR203697L3V
- RR203697L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For P2RX7
- Sino Biological Human cDNA Clone for P2RX7
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for P2RX7
- Novus Biologicals proteins and lysates for P2RX7
- Browse Antibodies
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- Taconic Biosciences Mouse Models for P2RX7
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for P2RX7 (AFLGC-P2RX7)
- ApexBio compounds for P2RX7
- VectorBuilder Custom and pre-made DNA vectors for P2RX7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for P2RX7 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for P2RX7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for P2RX7
- antibodies-online: Show 35 available P2RX7 Antibodies ranked by validation data
- Compare Top P2RX7 Antibodies
- Recommended
- 86 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 40 WB Antibodies (anti-mouse)
- 17 IF Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 27 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- antibodies-online: Show 19 available P2RX7 Elisa Kits ranked by validation data
- Compare Top P2RX7 Elisa Kits
- antibodies-online: Show 8 available P2RX7 Proteins ranked by validation data
- Compare Top P2RX7 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for P2RX7
- Search Santa Cruz Biotechnology (SCBT) for P2RX7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for P2RX7
- Custom Antibody ServicesProSci Antibodies for P2RX7
- Search for P2RX7 Proteins at ProSci
- Horizon Cell Lines for P2RX7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for P2RX7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for P2RX7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX7
Sources for P2RX7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB