Aliases for P2RX4 Gene
Aliases for P2RX4 Gene
External Ids for P2RX4 Gene
- HGNC: 8535
- Entrez Gene: 5025
- Ensembl: ENSG00000135124
- OMIM: 600846
- UniProtKB: Q99571
Previous GeneCards Identifiers for P2RX4 Gene
- GC12P120510
- GC12P121227
- GC12P121430
- GC12P120059
- GC12P120110
- GC12P121647
- GC12P118657
- GC12P121229
- GC12P121281
- GC12P121337
- GC12P121401
- GC12P121465
- GC12P121686
- GC12P122014
- GC12P122100
Summaries for P2RX4 Gene
-
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for P2RX4 Gene
P2RX4 (Purinergic Receptor P2X 4) is a Protein Coding gene. Diseases associated with P2RX4 include Chronic Pain. Among its related pathways are Platelet homeostasis and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is P2RX1.
UniProtKB/Swiss-Prot for P2RX4 Gene
-
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
-
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.
Additional gene information for P2RX4 Gene
- Monarch Initiative
- Search for P2RX4 at DataMed
- Search for P2RX4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX4 Gene
Genomics for P2RX4 Gene
GeneHancer (GH) Regulatory Elements for P2RX4 Gene
Promoters and enhancers for P2RX4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around P2RX4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the P2RX4 gene promoter:
-
- SRY
- POU2F1a
- POU2F1
- p300
- PPAR-gamma2
- PPAR-gamma1
- IRF-7A
- RSRFC4
- STAT5A
- FOXD3
Regulatory Element Products
Genomic Locations for P2RX4 Gene
Genomic Locations for P2RX4 Gene
- chr12:121,209,857-121,234,106
- (GRCh38/hg38)
- Size:
- 24,250 bases
- Orientation:
- Plus strand
- chr12:121,647,660-121,671,909
- (GRCh37/hg19)
- Size:
- 24,250 bases
- Orientation:
- Plus strand
Genomic View for P2RX4 Gene
Genes around P2RX4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
- 12q24.31 by Ensembl
P2RX4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for P2RX4 Gene
Proteins for P2RX4 Gene
-
Protein details for P2RX4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99571-P2RX4_HUMAN
- Recommended name:
- P2X purinoceptor 4
- Protein Accession:
- Q99571
- E7EPF7
- F6RU17
- O00450
- O14722
- Q5U089
- Q5U090
- Q8N4N1
- Q9UBG9
Protein attributes for P2RX4 Gene
- Size:
- 388 amino acids
- Molecular mass:
- 43369 Da
- Quaternary structure:
-
- Functional P2XRs are organized as homomeric and heteromeric trimers.
Protein Expression for P2RX4 Gene
Post-translational modifications for P2RX4 Gene
Other Protein References for P2RX4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for P2RX4
- Novus Biologicals Antibodies for P2RX4
- Invitrogen Antibodies for P2RX4
- GeneTex P2rx4 Antibody for P2RX4
Protein Products
-
OriGene Purified Proteins for P2RX4
- Search Origene for MassSpec and Protein Over-expression Lysates for P2RX4
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- Search GeneTex for Proteins for P2RX4
Assay Products
No data available for DME Specific Peptides for P2RX4 Gene
Domains & Families for P2RX4 Gene
Gene Families for P2RX4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for P2RX4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for P2RX4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99571- Family:
-
- Belongs to the P2X receptor family.
Function for P2RX4 Gene
Molecular function for P2RX4 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
- GENATLAS Biochemistry:
- purinoceptor,P2X4,ionotropic class,expressed in heart and spinal cord
Phenotypes From GWAS Catalog for P2RX4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001614 | purinergic nucleotide receptor activity | IMP | 11606481 |
| GO:0004931 | extracellularly ATP-gated cation channel activity | IDA,IEA | 9016352 |
| GO:0005102 | signaling receptor binding | ISS | 17785580 |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005507 | copper ion binding | ISS | 12819199 |
Phenotypes for P2RX4 Gene
- MGI mutant phenotypes for P2RX4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for P2RX4:
Animal Models for P2RX4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for P2RX4
- Cyagen custom Knockout/knockin (KOKI) mouse models for P2RX4
-
CRISPR Products
-
OriGene CRISPR knockouts for P2RX4
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- Overview of 99 available P2RX4 gene related products
- Applied Biological Materials CRISPR for P2RX4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for P2RX4
- GenScript: Design CRISPR guide RNA sequences for P2RX4
miRNA for P2RX4 Gene
- miRTarBase miRNAs that target P2RX4
miRNA Products
Inhibitory RNA Products
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- Overview of 99 available P2RX4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for P2RX4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX4
- Applied Biological Materials Clones for P2RX4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for P2RX4 (P2X4)
Cell Line Products
-
Horizon Cell Lines for P2RX4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX4 Gene
Localization for P2RX4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for P2RX4 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 1 |
- Actin filaments (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005639 | integral component of nuclear inner membrane | IBA | -- |
| GO:0005765 | lysosomal membrane | HDA | 17897319 |
| GO:0005886 | plasma membrane | TAS,ISS | -- |
| GO:0005887 | integral component of plasma membrane | IEA,IMP | 10515189 |
| GO:0014069 | postsynaptic density | IEA | -- |
Pathways & Interactions for P2RX4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Platelet homeostasis | ||
| 2 | Calcium signaling pathway | ||
| 3 | Peptide ligand-binding receptors | ||
| 4 | Ca, cAMP and Lipid Signaling | ||
| 5 | Neuroscience | ||
Pathways by source for P2RX4 Gene
4 Reactome pathways for P2RX4 Gene
2 KEGG pathways for P2RX4 Gene
1 Qiagen pathway for P2RX4 Gene
2 Cell Signaling Technology pathways for P2RX4 Gene
Interacting Proteins for P2RX4 Gene
Selected Interacting proteins:
Q99571-P2RX4_HUMAN
ENSP00000336607
for P2RX4 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for P2RX4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001894 | tissue homeostasis | NAS | 17264311 |
| GO:0002028 | regulation of sodium ion transport | ISS | 17785580 |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | IBA | -- |
| GO:0007165 | signal transduction | IDA | 9016352 |
No data available for SIGNOR curated interactions for P2RX4 Gene
Drugs & Compounds for P2RX4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Eslicarbazepine acetate | Approved | Pharma | Target, antagonist | 67 | ||
| Ivermectin | Approved, Investigational, Vet_approved | Pharma | NAChR/purinergic P2X4 receptor modulator | 70 | ||
| KN-93 | Pharma | CaMKII inhibitor,selective and cometitive | 0 | |||
| 2-Methylthioadenosine triphosphate tetrasodium salt | Pharma | P2 purinergic agonist | 0 | |||
| NF 157 | Pharma | Selective P2Y11/P2X1 antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ATPgammaS tetralithium salt |
|
93839-89-5 |
|
|
(5) Tocris Compounds for P2RX4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-Methylthioadenosine triphosphate tetrasodium salt | P2 purinergic agonist | 100020-57-3 |
| ATPgammaS tetralithium salt | P2 agonist; ATP (Cat. No. 3245) analog | 93839-89-5 |
| NF 157 | Selective P2Y11/P2X1 antagonist | 104869-26-3 |
| PPADS tetrasodium salt | P2 purinergic antagonist | 192575-19-2 |
| Suramin hexasodium salt | Non-selective P2 antagonist | 129-46-4 |
(2) ApexBio Compounds for P2RX4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ivermectin | NAChR/purinergic P2X4 receptor modulator | 70288-86-7 |
| KN-93 | CaMKII inhibitor,selective and cometitive | 139298-40-1 |
Transcripts for P2RX4 Gene
mRNA/cDNA for P2RX4 Gene
- (7) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (164) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000314442 4658 bps (uc058ugb.1)
- ENST00000337233 2032 bps (uc001tzr.4)
- ENST00000359949 1836 bps (uc031qjt.2)
- ENST00000397924 880 bps (uc058ugc.1)
- ENST00000499638 3145 bps (uc058ufv.1)
Unigene Clusters for P2RX4 Gene
- Purinergic receptor P2X, ligand-gated ion channel, 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for P2RX4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for P2RX4
- genomics-online: gRNA clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- Applied Biological Materials CRISPR for P2RX4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for P2RX4
- GenScript: Design CRISPR guide RNA sequences for P2RX4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for P2RX4
- Browse OriGene Inhibitory RNA Products For P2RX4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX4
- genomics-online: shRNA clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for P2RX4
- VectorBuilder custom plasmid, inducible vectors for P2RX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for P2RX4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX4
- Applied Biological Materials Clones for P2RX4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for P2RX4 (P2X4)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for P2RX4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
This gene is overexpressed in Liver (22.4), Islet of Langerhans (10.6), and Placenta (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for P2RX4 Gene
NURSA nuclear receptor signaling pathways regulating expression of P2RX4 Gene:
P2RX4SOURCE GeneReport for Unigene cluster for P2RX4 Gene:
Hs.321709Evidence on tissue expression from TISSUES for P2RX4 Gene
- Nervous system(4.5)
- Blood(4.4)
- Kidney(4.4)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for P2RX4
-
OriGene qPCR primer pairs for P2RX4
- genomics-online: primer clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RX4 Gene
Orthologs for P2RX4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | P2RX4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | P2X4 34 |
|
OneToOne | |
| P2RX4 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | P2RX4 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | P2rx4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | P2rx4 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | P2RX4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | P2RX4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | P2RX4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | P2RX4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | p2rx4 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398206 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | p2rx4a 34 33 33 |
|
OneToMany | |
| p2rx4b 34 |
|
OneToMany |
- Species where no ortholog for P2RX4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for P2RX4 Gene
- ENSEMBL:
- Gene Tree for P2RX4 (if available)
- TreeFam:
- Gene Tree for P2RX4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for P2RX4: view image
Paralogs for P2RX4 Gene
(7) SIMAP similar genes for P2RX4 Gene using alignment to 8 proteins:
- P2RX4_HUMAN
- B7Z1M5_HUMAN
- B7Z4R5_HUMAN
- F5GZQ9_HUMAN
- F5H1M6_HUMAN
- F5H2S3_HUMAN
- H0YF70_HUMAN
- K4KBD6_HUMAN
Variants for P2RX4 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013156 | -- | 121,228,455(+) | G/A | intron_variant | |
| rs1000170918 | -- | 121,232,223(+) | G/C | intron_variant | |
| rs1000218023 | -- | 121,226,528(+) | A/G | intron_variant | |
| rs1000280493 | -- | 121,226,971(+) | C/G | intron_variant | |
| rs1000353493 | -- | 121,226,775(+) | C/A/T | intron_variant |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.90;
83.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for P2RX4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX4 Gene
Disorders for P2RX4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic pain |
|
|
Search P2RX4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for P2RX4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX4 Gene
Publications for P2RX4 Gene
- Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PMID: 18852390) Palomino-Doza J … Keavney B (Hypertension (Dallas, Tex. : 1979) 2008) 3 22 44 58
- Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M … Stühmer W (Molecular pharmacology 1997) 2 3 4 58
- Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis. (PMID: 28326637) Sadovnick AD … Vilariño-Güell C (Human mutation 2017) 3 4 58
- A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. (PMID: 23303206) Gu BJ … Wiley JS (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013) 3 4 58
- A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure. (PMID: 22068874) Stokes L … Wiley JS (Hypertension (Dallas, Tex. : 1979) 2011) 3 4 58
Products for P2RX4 Gene
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for P2RX4
- Novus Biologicals proteins and lysates for P2RX4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for P2RX4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for P2RX4
- ApexBio compounds for P2RX4
- Cyagen custom Knockout/knockin (KOKI) mouse models for P2RX4
- VectorBuilder custom plasmid, inducible vectors for P2RX4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for P2RX4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 60 available P2RX4 Antibodies ranked by validation data
- Compare Top P2RX4 Antibodies
- antibodies-online: Search results for available P2RX4 related products ranked by validation data
- antibodies-online: Search results for 5 available P2RX4 Proteins ranked by validation data
- Compare Top P2RX4 Proteins
- GeneTex P2rx4 Antibody for P2RX4
- Search GeneTex for Proteins for P2RX4
- Horizon Cell Lines for P2RX4
- genomics-online: cdna clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- orf clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- genomics-online: gRNA clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- genomics-online: primer clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- genomics-online: shRNA clones - Search results for 99 available P2RX4 gene related products
- Overview of 99 available P2RX4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for P2RX4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for P2RX4
- GeneCopoeia miRNA 3'UTR Target clone products for P2RX4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX4
Sources for P2RX4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt