Aliases for P2RX3 Gene
External Ids for P2RX3 Gene
Previous GeneCards Identifiers for P2RX3 Gene
This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
GeneCards Summary for P2RX3 Gene
P2RX3 (Purinergic Receptor P2X 3) is a Protein Coding gene. Diseases associated with P2RX3 include Interstitial Cystitis and Low Compliance Bladder. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Platelet homeostasis. Gene Ontology (GO) annotations related to this gene include ion channel activity and extracellularly ATP-gated cation channel activity. An important paralog of this gene is P2RX2.
UniProtKB/Swiss-Prot Summary for P2RX3 Gene
Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.