This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is ... See more...

Aliases for P2RX3 Gene

Aliases for P2RX3 Gene

  • Purinergic Receptor P2X 3 2 3 5
  • P2X3 2 3 4
  • P2X Purinoceptor 3 3 4
  • ATP Receptor 3 4
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 3 2
  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 3 3
  • Purinergic Receptor P2X3 3
  • P2X Receptor, Subunit 3 3
  • Purinergic Receptor 4
  • Purinoceptor P2X3 3
  • P2RX3 5

External Ids for P2RX3 Gene

Previous GeneCards Identifiers for P2RX3 Gene

  • GC11P059499
  • GC11P058618
  • GC11P056881
  • GC11P056862
  • GC11P057105
  • GC11P053454

Summaries for P2RX3 Gene

Entrez Gene Summary for P2RX3 Gene

  • This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

GeneCards Summary for P2RX3 Gene

P2RX3 (Purinergic Receptor P2X 3) is a Protein Coding gene. Diseases associated with P2RX3 include Interstitial Cystitis and Low Compliance Bladder. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Platelet homeostasis. Gene Ontology (GO) annotations related to this gene include ion channel activity and extracellularly ATP-gated cation channel activity. An important paralog of this gene is P2RX2.

UniProtKB/Swiss-Prot Summary for P2RX3 Gene

  • Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).

Tocris Summary for P2RX3 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for P2RX3 Gene

Genomics for P2RX3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for P2RX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057334 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 254.9 -0.3 -321 2.8 TBP SP1 NR2C1 MNT SMAD5 ETS1 IRF2 ZFP64 MBD2 POLR2A SSRP1 P2RX3 MN309246 TNKS1BP1 CLP1 ZDHHC5 LRRC55
GH11J057338 Promoter/Enhancer 1.2 EPDnew Ensembl CraniofacialAtlas 250.7 +3.4 3399 2.9 CTCF BHLHE40 SIN3A REST ZFP91 SKIL RAD21 ZNF2 PKNOX1 ATF4 P2RX3 TNKS1BP1 HSALNG0084264 PRG3
GH11J057402 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +72.0 71958 13 BCL11A MNT IKZF1 HES1 ZNF513 ZNF395 REST GABPA IRF4 ZEB2 JX952206 RTN4RL2 P2RX3 SLC43A3 RN7SKP259 SSRP1 PRG2 SLC43A1 TIMM10 UBE2L6
GH11J057529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +194.7 194733 2.6 TBP MXD4 NR2C1 MNT SMAD5 ETS1 IRF2 HES1 POLR2A BRCA1 lnc-SMTNL1-1 piR-47821 piR-46301 TIMM10 SSRP1 CLP1 YPEL4 MIR130A UBE2L6 RPS4XP13
GH11J057496 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +164.0 163986 6.7 CEBPA FOXA1 MNT MBD2 BHLHE40 NONO ZIC2 KDM6A THAP11 SIN3A TIMM10 SSRP1 RTN4RL2 RN7SKP259 MIR130A SLC43A3 ENSG00000254979 P2RX3 ENSG00000254602 CLP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around P2RX3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for P2RX3

Top Transcription factor binding sites by QIAGEN in the P2RX3 gene promoter:
  • E47
  • Egr-4
  • GATA-1
  • Hand1
  • HFH-1
  • Lmo2
  • Pax-4a
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for P2RX3 Gene

Latest Assembly
chr11:57,335,943-57,372,399
(GRCh38/hg38)
Size:
36,457 bases
Orientation:
Plus strand

Previous Assembly
chr11:57,105,826-57,139,869
(GRCh37/hg19 by Entrez Gene)
Size:
34,044 bases
Orientation:
Plus strand

chr11:57,105,848-57,138,073
(GRCh37/hg19 by Ensembl)
Size:
32,226 bases
Orientation:
Plus strand

Genomic View for P2RX3 Gene

Genes around P2RX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX3 Gene

Proteins for P2RX3 Gene

  • Protein details for P2RX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56373-P2RX3_HUMAN
    Recommended name:
    P2X purinoceptor 3
    Protein Accession:
    P56373
    Secondary Accessions:
    • Q6DK37
    • Q9UQB6

    Protein attributes for P2RX3 Gene

    Size:
    397 amino acids
    Molecular mass:
    44289 Da
    Quaternary structure:
    • Homotrimer (PubMed:27626375). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity).

    Three dimensional structures from OCA and Proteopedia for P2RX3 Gene

neXtProt entry for P2RX3 Gene

Post-translational modifications for P2RX3 Gene

  • Glycosylation at Asn139, Asn170, Asn194, and Asn290
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for P2RX3
  • Santa Cruz Biotechnology (SCBT) Antibodies for P2RX3

No data available for DME Specific Peptides for P2RX3 Gene

Domains & Families for P2RX3 Gene

Gene Families for P2RX3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for P2RX3 Gene

InterPro:
Blocks:
  • ATP P2X receptor
  • P2X3 purinoceptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for P2RX3 Gene

GenScript: Design optimal peptide antigens:
  • P2X purinoceptor (C9J142_HUMAN)
  • Purinergic receptor (P2RX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56373

UniProtKB/Swiss-Prot:

P2RX3_HUMAN :
  • Belongs to the P2X receptor family.
Family:
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX3: view

Function for P2RX3 Gene

Molecular function for P2RX3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
GENATLAS Biochemistry:
purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory neurons,fibers,running into the spinal cord

Phenotypes From GWAS Catalog for P2RX3 Gene

Gene Ontology (GO) - Molecular Function for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001614 purinergic nucleotide receptor activity IEA,NAS 17895406
GO:0004931 extracellularly ATP-gated cation channel activity IEA,NAS 17895406
GO:0005216 ion channel activity IEA --
GO:0005524 ATP binding IEA,NAS 17895406
genes like me logo Genes that share ontologies with P2RX3: view
genes like me logo Genes that share phenotypes with P2RX3: view

Animal Models for P2RX3 Gene

MGI Knock Outs for P2RX3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX3 Gene

Localization for P2RX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RX3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 3
extracellular 2
cytoskeleton 2
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA 21873635
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IMP 27626375
genes like me logo Genes that share ontologies with P2RX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RX3 Gene

Pathways & Interactions for P2RX3 Gene

genes like me logo Genes that share pathways with P2RX3: view

Pathways by source for P2RX3 Gene

1 Qiagen pathway for P2RX3 Gene
  • Intracellular Calcium Signaling

Interacting Proteins for P2RX3 Gene

Gene Ontology (GO) - Biological Process for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0007165 signal transduction TAS 9221902
GO:0007268 chemical synaptic transmission IEA --
genes like me logo Genes that share ontologies with P2RX3: view

No data available for SIGNOR curated interactions for P2RX3 Gene

Drugs & Compounds for P2RX3 Gene

(38) Drugs for P2RX3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Promethazine Approved, Investigational Pharma Target, inhibitor 492
BzATP Pharma Agonist, Full agonist 0
TNP-ATP Pharma Antagonist 0
2-Methylthioadenosine triphosphate tetrasodium salt Pharma P2 purinergic agonist 0
NF 157 Pharma Selective P2Y11/P2X1 antagonist 0

(4) Additional Compounds for P2RX3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ATPgammaS tetralithium salt
93839-89-5

(5) Tocris Compounds for P2RX3 Gene

Compound Action Cas Number
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog 93839-89-5
NF 157 Selective P2Y11/P2X1 antagonist 104869-26-3
PPADS tetrasodium salt P2 purinergic antagonist 192575-19-2
Suramin hexasodium salt Non-selective P2 antagonist 129-46-4

(20) ApexBio Compounds for P2RX3 Gene

Compound Action Cas Number
2-Methylthioadenosine triphosphate tetrasodium salt 100020-57-3
A-317491 P2X3 and P2X2/3 receptor antagonist 475205-49-3
BzATP triethylammonium salt 112898-15-4
iso-PPADS tetrasodium salt P2 purinoceptors antagonist, specific 207572-67-6
KN-92 hydrochloride Inactive derivative of KN-93,control compound 1431698-47-3
KN-93 CaMKII inhibitor,selective and cometitive 139298-40-1
MRS 2219 14141-47-0
NF 023 104869-31-0
NF 110 111150-22-2
NF 157 104869-26-3
NF 279 202983-32-2
NF 449 purinergic receptor antagonist 627034-85-9
PPADS tetrasodium salt 192575-19-2
PPNDS 1021868-77-8
Ro 0437626 134362-79-1
Ro 51 1050670-85-3
RO-3 1026582-88-6
Suramin hexasodium salt 129-46-4
TC-P 262 873398-67-5
TNP-ATP triethylammonium salt 61368-63-6
genes like me logo Genes that share compounds with P2RX3: view

Drug products for research

Transcripts for P2RX3 Gene

mRNA/cDNA for P2RX3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for P2RX3

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:

Relevant External Links for P2RX3 Gene

GeneLoc Exon Structure for
P2RX3

Expression for P2RX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RX3 Gene

This gene is overexpressed in Testis (x27.7) and Heart - Left Ventricle (x13.0).

Protein differential expression in normal tissues from HIPED for P2RX3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RX3 Gene



Protein tissue co-expression partners for P2RX3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for P2RX3

SOURCE GeneReport for Unigene cluster for P2RX3 Gene:

Hs.146738

Evidence on tissue expression from TISSUES for P2RX3 Gene

  • Nervous system(4.5)
  • Heart(4.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with P2RX3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RX3 Gene

Orthologs for P2RX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia P2RX3 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia P2X3 31
  • 95 (a)
OneToOne
P2RX3 30
  • 90.26 (n)
Mouse
(Mus musculus)
Mammalia P2rx3 30 17 31
  • 89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia P2rx3 30
  • 88.33 (n)
Oppossum
(Monodelphis domestica)
Mammalia P2RX3 31
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia P2RX3 30 31
  • 87.99 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia P2RX3 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC423134 30
  • 71.57 (n)
P2RX3 31
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia P2RX3 31
  • 76 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii p2rx3b 30 31
  • 66.58 (n)
OneToOne
Species where no ortholog for P2RX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for P2RX3 Gene

ENSEMBL:
Gene Tree for P2RX3 (if available)
TreeFam:
Gene Tree for P2RX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for P2RX3: view image

Paralogs for P2RX3 Gene

Paralogs for P2RX3 Gene

(6) SIMAP similar genes for P2RX3 Gene using alignment to 2 proteins:

  • P2RX3_HUMAN
  • H0YDR6_HUMAN
genes like me logo Genes that share paralogs with P2RX3: view

Variants for P2RX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for P2RX3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs115850675 Benign: not provided 57,348,212(+) G/A
NM_002559.5(P2RX3):c.434G>A (p.Arg145Gln)
MISSENSE
rs547284438 Likely Benign: not provided 57,338,558(+) GC/G
NM_002559.5(P2RX3):c.9del (p.Asn2_Cys3insTer)
NONSENSE
rs77399385 Benign: not provided 57,369,351(+) C/A
NM_002559.5(P2RX3):c.1003-10C>A
rs2276038 - p.Ala383Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for P2RX3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for P2RX3 Gene

Variant ID Type Subtype PubMed ID
nsv1144568 CNV deletion 24896259

Variation tolerance for P2RX3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RX3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX3 Gene

Disorders for P2RX3 Gene

MalaCards: The human disease database

(25) MalaCards diseases for P2RX3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
interstitial cystitis
  • ulcerative cystitis
low compliance bladder
  • hyperactivity of bladder
detrusor sphincter dyssynergia
  • detrusor and sphincter dyssynergia
femoral cancer
  • femoral neoplasm
cystitis
  • infective cystitis
- elite association - COSMIC cancer census association via MalaCards
Search P2RX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for P2RX3

genes like me logo Genes that share disorders with P2RX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX3 Gene

Publications for P2RX3 Gene

  1. X-ray structures define human P2X(3) receptor gating cycle and antagonist action. (PMID: 27626375) Mansoor SE … Gouaux E (Nature 2016) 3 4
  2. Expression of P2X3 purinoceptors in suburothelial myofibroblasts of the normal human urinary bladder. (PMID: 19456993) Liu F … Yamaguchi O (International journal of urology : official journal of the Japanese Urological Association 2009) 3 23
  3. Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. (PMID: 14520770) Renton T … Anand P (Journal of orofacial pain 2003) 3 23
  4. Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. (PMID: 12885270) Jarvis MF (Expert opinion on therapeutic targets 2003) 3 23
  5. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M … Stühmer W (Molecular pharmacology 1997) 3 4

Products for P2RX3 Gene

Sources for P2RX3 Gene