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Aliases for OXLD1 Gene

Subcategory (RNA class) for OXLD1 Gene

lncRNA

Aliases for OXLD1 Gene

  • Oxidoreductase Like Domain Containing 1 2 3 5
  • C17orf90 3 4
  • Oxidoreductase-Like Domain-Containing Protein 1 3
  • Oxidoreductase-Like Domain Containing 1 2
  • Chromosome 17 Open Reading Frame 90 2

External Ids for OXLD1 Gene

ORGUL Members for OXLD1 Gene

Previous HGNC Symbols for OXLD1 Gene

  • C17orf90

Previous GeneCards Identifiers for OXLD1 Gene

  • GC17M079633

Summaries for OXLD1 Gene

GeneCards Summary for OXLD1 Gene

OXLD1 (Oxidoreductase Like Domain Containing 1) is a Protein Coding gene, and is affiliated with the lncRNA class.

Additional gene information for OXLD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXLD1 Gene

Genomics for OXLD1 Gene

GeneHancer (GH) Regulatory Elements for OXLD1 Gene

Promoters and enhancers for OXLD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081664 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -201 3.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 CCDC137 OXLD1 ARL16 OGFOD3 HGS FAAP100 ALYREF ENSG00000262877 FOXK2 CEP131
GH17I082271 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 -606.4 -606435 3.5 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CSNK1D OGFOD3 OXLD1 ENSG00000263321 ALYREF HGS ENSG00000260011 ENSG00000262877 CCDC137 ENSG00000262663
GH17I081221 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.4 +443.7 443679 2.5 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 POLR2B ZNF207 ZNF143 FOS CEP131 ALYREF HGS TEPSIN OXLD1 FAAP100 ACTG1 ENSG00000265678 DUS1L CHMP6
GH17I080831 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +832.9 832931 4.6 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 YY1 POLR2B ZNF207 FOS OXLD1 HGS CCDC137 CEP131 LOC105371925 ENSG00000262877 TEPSIN LOC101928855 LOC105371921 RPTOR
GH17I081558 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.9 +102.3 102275 11.1 PKNOX1 FOXA2 NFIB ZSCAN4 SIN3A FEZF1 BATF RAD21 ZNF366 ATF7 NPLOC4 TSPAN10 ARL16 OXLD1 ENSG00000229848 FSCN2 ENSG00000262877 PDE6G CCDC137 GCGR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OXLD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OXLD1 Gene

Genomic Locations for OXLD1 Gene
chr17:81,665,036-81,666,637
(GRCh38/hg38)
Size:
1,602 bases
Orientation:
Minus strand
chr17:79,632,066-79,633,665
(GRCh37/hg19)

Genomic View for OXLD1 Gene

Genes around OXLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXLD1 Gene

Proteins for OXLD1 Gene

  • Protein details for OXLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKU9-OXLD1_HUMAN
    Recommended name:
    Oxidoreductase-like domain-containing protein 1
    Protein Accession:
    Q5BKU9
    Secondary Accessions:
    • A6ND24

    Protein attributes for OXLD1 Gene

    Size:
    147 amino acids
    Molecular mass:
    15855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXLD1 Gene

Post-translational modifications for OXLD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for OXLD1 Gene

Domains & Families for OXLD1 Gene

Gene Families for OXLD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OXLD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OXLD1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for OXLD1 Gene

Function for OXLD1 Gene

Phenotypes From GWAS Catalog for OXLD1 Gene

Phenotypes for OXLD1 Gene

genes like me logo Genes that share phenotypes with OXLD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXLD1 Gene

Localization for OXLD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXLD1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OXLD1 Gene

Pathways & Interactions for OXLD1 Gene

SuperPathways for OXLD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OXLD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OXLD1 Gene

Drugs & Compounds for OXLD1 Gene

No Compound Related Data Available

Transcripts for OXLD1 Gene

mRNA/cDNA for OXLD1 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXLD1 Gene

Oxidoreductase-like domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXLD1 Gene

No ASD Table

Relevant External Links for OXLD1 Gene

GeneLoc Exon Structure for
OXLD1
ECgene alternative splicing isoforms for
OXLD1

Expression for OXLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OXLD1 Gene

Protein differential expression in normal tissues from HIPED for OXLD1 Gene

This gene is overexpressed in Lung (19.2), Heart (10.9), Frontal cortex (7.5), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OXLD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OXLD1 Gene:

OXLD1

SOURCE GeneReport for Unigene cluster for OXLD1 Gene:

Hs.405942
genes like me logo Genes that share expression patterns with OXLD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OXLD1 Gene

Orthologs for OXLD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXLD1 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia OXLD1 33 34
  • 78.46 (n)
cow
(Bos Taurus)
Mammalia OXLD1 33 34
  • 78.01 (n)
mouse
(Mus musculus)
Mammalia Oxld1 33 16 34
  • 72.26 (n)
lizard
(Anolis carolinensis)
Reptilia OXLD1 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oxld1 34
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5500 34
  • 27 (a)
OneToOne
Species where no ortholog for OXLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXLD1 Gene

ENSEMBL:
Gene Tree for OXLD1 (if available)
TreeFam:
Gene Tree for OXLD1 (if available)

Paralogs for OXLD1 Gene

No data available for Paralogs for OXLD1 Gene

Variants for OXLD1 Gene

Sequence variations from dbSNP and Humsavar for OXLD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030742 -- 81,667,578(-) C/A upstream_transcript_variant
rs1001800344 -- 81,666,015(-) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1003013854 -- 81,666,803(-) G/C/T upstream_transcript_variant
rs1003191696 -- 81,666,400(-) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1003265369 -- 81,666,099(-) G/ 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OXLD1 Gene

Variant ID Type Subtype PubMed ID
nsv952390 CNV deletion 24416366
nsv828128 CNV loss 20364138
nsv470620 CNV loss 18288195
nsv428351 CNV gain 18775914
esv26223 CNV gain+loss 19812545

Variation tolerance for OXLD1 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OXLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXLD1 Gene

Disorders for OXLD1 Gene

Additional Disease Information for OXLD1

No disorders were found for OXLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXLD1 Gene

Publications for OXLD1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OXLD1 Gene

Sources for OXLD1 Gene

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