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Aliases for OXGR1 Gene

Aliases for OXGR1 Gene

  • Oxoglutarate Receptor 1 2 3 5
  • Alpha-Ketoglutarate Receptor 1 2 3 4
  • Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 2 3
  • G Protein-Coupled Receptor 80 2 3
  • G-Protein Coupled Receptor 99 3 4
  • P2Y-Like Nucleotide Receptor 3 4
  • 2-Oxoglutarate Receptor 1 2 3
  • P2Y Purinoceptor 15 3 4
  • P2Y-Like GPCR 3 4
  • P2RY15 3 4
  • GPR80 3 4
  • GPR99 3 4
  • P2Y15 3 4
  • Seven Transmembrane Helix Receptor 3
  • G-Protein Coupled Receptor 80 4
  • AKGR 3

External Ids for OXGR1 Gene

Previous HGNC Symbols for OXGR1 Gene

  • GPR99
  • GPR80

Previous GeneCards Identifiers for OXGR1 Gene

  • GC13M096435
  • GC13M097637
  • GC13M078234

Summaries for OXGR1 Gene

Entrez Gene Summary for OXGR1 Gene

  • This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for OXGR1 Gene

OXGR1 (Oxoglutarate Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY1.

UniProtKB/Swiss-Prot for OXGR1 Gene

  • Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).

Gene Wiki entry for OXGR1 Gene

Additional gene information for OXGR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXGR1 Gene

Genomics for OXGR1 Gene

GeneHancer (GH) Regulatory Elements for OXGR1 Gene

Promoters and enhancers for OXGR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J096993 Promoter/Enhancer 1.2 EPDnew Ensembl 667.5 +1.5 1514 0.9 CTCF ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 ZNF600 EZH2 OXGR1 GC13P096999 RAP2A TULP3P1 LINC00359
GH13J096983 Enhancer 0.8 Ensembl ENCODE 25.4 +11.7 11731 1.1 CTCF IRF2 HLF TAL1 CBFA2T3 NR2F2 TCF12 PRDM6 ZNF512 RCOR1 TULP3P1 LINC00359 OXGR1 RN7SKP7
GH13J097109 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.4 -114.2 -114233 1 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 DEK MBNL2 OXGR1 GC13P097093
GH13J097221 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 -229.0 -229040 6.9 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B FOS MBNL2 OXGR1 GC13P097244 PIR38499 LINC00456
GH13J096925 Enhancer 0.8 ENCODE 13.8 +69.5 69462 1 ELF3 FOXA2 MLX RARA CREM MIXL1 HMG20B RXRA PPARG NFIL3 OXGR1 PIR53127 HSP90AB6P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OXGR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OXGR1 gene promoter:
  • MEF-2A
  • aMEF-2
  • AP-4
  • C/EBPbeta
  • Cdc5
  • Pbx1a
  • NF-AT
  • NF-AT1

Genomic Locations for OXGR1 Gene

Genomic Locations for OXGR1 Gene
10,108 bases
Minus strand
9,012 bases
Minus strand

Genomic View for OXGR1 Gene

Genes around OXGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXGR1 Gene

Proteins for OXGR1 Gene

  • Protein details for OXGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-oxoglutarate receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q5T5A7
    • Q86TL1

    Protein attributes for OXGR1 Gene

    337 amino acids
    Molecular mass:
    38251 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXGR1 Gene

Post-translational modifications for OXGR1 Gene

  • Glycosylation at Asn179, Asn176, Asn23, and Asn10
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OXGR1 Gene

Domains & Families for OXGR1 Gene

Gene Families for OXGR1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OXGR1 Gene

Suggested Antigen Peptide Sequences for OXGR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OXGR1: view

Function for OXGR1 Gene

Molecular function for OXGR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).

Phenotypes From GWAS Catalog for OXGR1 Gene

Gene Ontology (GO) - Molecular Function for OXGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OXGR1: view
genes like me logo Genes that share phenotypes with OXGR1: view

Animal Models for OXGR1 Gene

MGI Knock Outs for OXGR1:
  • Oxgr1 Oxgr1<tm1(KOMP)Vlcg>

Animal Model Products

Clone Products

  • Addgene plasmids for OXGR1
  • R&D Systems cDNA Clones for OXGR1 (OXGR1/GPR80/P2Y15)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OXGR1 Gene

Localization for OXGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXGR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXGR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OXGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 12098360
genes like me logo Genes that share ontologies with OXGR1: view

Pathways & Interactions for OXGR1 Gene

genes like me logo Genes that share pathways with OXGR1: view

Gene Ontology (GO) - Biological Process for OXGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 12098360
genes like me logo Genes that share ontologies with OXGR1: view

No data available for SIGNOR curated interactions for OXGR1 Gene

Drugs & Compounds for OXGR1 Gene

(2) Drugs for OXGR1 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Ketobutyric acid Experimental Pharma 0

(1) Additional Compounds for OXGR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-ketoglutaric acid
Full agonist, Agonist
genes like me logo Genes that share compounds with OXGR1: view

Transcripts for OXGR1 Gene

mRNA/cDNA for OXGR1 Gene

(6) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXGR1 Gene

Oxoglutarate (alpha-ketoglutarate) receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for OXGR1
  • R&D Systems cDNA Clones for OXGR1 (OXGR1/GPR80/P2Y15)

Alternative Splicing Database (ASD) splice patterns (SP) for OXGR1 Gene

No ASD Table

Relevant External Links for OXGR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OXGR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OXGR1 Gene

mRNA differential expression in normal tissues according to GTEx for OXGR1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.5) and Skin - Not Sun Exposed (Suprapubic) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of OXGR1 Gene:


SOURCE GeneReport for Unigene cluster for OXGR1 Gene:


mRNA Expression by UniProt/SwissProt for OXGR1 Gene:

Tissue specificity: Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.

Evidence on tissue expression from TISSUES for OXGR1 Gene

  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with OXGR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OXGR1 Gene

Orthologs for OXGR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXGR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OXGR1 34 33
  • 99.31 (n)
(Canis familiaris)
Mammalia OXGR1 34 33
  • 88.43 (n)
(Bos Taurus)
Mammalia OXGR1 34 33
  • 84.08 (n)
(Mus musculus)
Mammalia Oxgr1 16 34 33
  • 82.79 (n)
(Rattus norvegicus)
Mammalia Oxgr1 33
  • 82 (n)
(Monodelphis domestica)
Mammalia OXGR1 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
(Gallus gallus)
Aves OXGR1 34 33
  • 65.08 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
-- 34
  • 50 (a)
(Danio rerio)
Actinopterygii oxgr1a.1 34 33
  • 54.63 (n)
oxgr1b 34
  • 44 (a)
oxgr1a.3 34
  • 40 (a)
oxgr1a.2 34
  • 40 (a)
Species where no ortholog for OXGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXGR1 Gene

Gene Tree for OXGR1 (if available)
Gene Tree for OXGR1 (if available)
Evolutionary constrained regions (ECRs) for OXGR1: view image

Paralogs for OXGR1 Gene

(25) SIMAP similar genes for OXGR1 Gene using alignment to 3 proteins:

  • F5H3P1_HUMAN
  • F5H6U5_HUMAN
genes like me logo Genes that share paralogs with OXGR1: view

Variants for OXGR1 Gene

Sequence variations from dbSNP and Humsavar for OXGR1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000161936 -- 96,996,012(-) T/C upstream_transcript_variant
rs1000193211 -- 96,993,270(-) G/A intron_variant
rs1000215024 -- 96,996,291(-) A/G upstream_transcript_variant
rs1000224163 -- 96,993,158(-) G/A intron_variant
rs1000564950 -- 96,994,143(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OXGR1 Gene

Variant ID Type Subtype PubMed ID
esv3633286 CNV loss 21293372
nsv7246 OTHER inversion 18451855
nsv832693 CNV loss 17160897

Variation tolerance for OXGR1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OXGR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXGR1 Gene

Disorders for OXGR1 Gene

Additional Disease Information for OXGR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OXGR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXGR1 Gene

Publications for OXGR1 Gene

  1. GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. (PMID: 12098360) Wittenberger T … Hampe W (BMC genomics 2002) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. (PMID: 19760608) Lu CY … Chang YS (Genes, chromosomes & cancer 2009) 3 22 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for OXGR1 Gene

Sources for OXGR1 Gene

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